INT66930

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Context Info
Confidence 0.15
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tcirg1) plasma membrane (Tcirg1)
Tcirg1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 5 99.04 Very High Very High Very High
Locus ceruleus 10 98.88 Very High Very High Very High
withdrawal 12 98.64 Very High Very High Very High
Morphine 6 98.14 Very High Very High Very High
Intracerebroventricular 1 84.08 Quite High
cva 13 83.04 Quite High
nMDA receptor 2 61.36 Quite High
Opioid 3 55.60 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
drug abuse 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 9 92.80 High High
Stroke 56 89.76 High High
Thrombosis Related Under Development 10 83.52 Quite High
Attention Deficit Hyperactivity Disorder 3 63.52 Quite High
Cardiovascular Disease 10 62.04 Quite High
Syndrome 2 56.64 Quite High
Disease 12 56.60 Quite High
Diabetes Mellitus 9 55.36 Quite High
Opiate Addiction 1 54.96 Quite High
Cv Unclassified Under Development 6 54.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The risk attributable to OC use in women < 35 years of age is small, even if they smoke, but there are substantially increased risks in older women who both smoke and use OC.
Positive_regulation (increased) of OC
1) Confidence 0.15 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 0.95 Pain Relevance 0.12
In animals chronically infused with morphine (15 micrograms/h, i.c.v., 5 days) a naloxone challenge (2 mg/kg, i.v.) produced significant increase (253.7 +/- 19.3% of baseline) in CA-OC signal.
Positive_regulation (increase) of CA-OC associated with narcan and morphine
2) Confidence 0.01 Published 1996 Journal Brain Res. Section Abstract Doc Link 8955938 Disease Relevance 0.23 Pain Relevance 1.48

General Comments

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