INT66940

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.61
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (RET) signal transduction (RET) plasma membrane (RET)
Anatomy Link Frequency
germ line 3
blood 1
plasma 1
neurons 1
bladder 1
RET (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 159 94.56 High High
Congenital analgesia 3 94.00 High High
Catecholamine 30 67.40 Quite High
headache 3 31.24 Quite Low
imagery 15 5.00 Very Low Very Low Very Low
noradrenaline 4 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Dysuria 3 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Endocrine Neoplasia Type 2a 5 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2b 3 100.00 Very High Very High Very High
Cancer 164 99.96 Very High Very High Very High
Disease 38 99.92 Very High Very High Very High
Syndrome 6 99.72 Very High Very High Very High
Transitional Cell Carcinoma 78 98.00 Very High Very High Very High
Hirschsprung Disease 3 97.96 Very High Very High Very High
Paraganglioma 48 94.16 High High
Pheochromocytoma 50 93.44 High High
Pain 3 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RET is affected by germ line and somatic mutations in MEN2A, MEN2B tumor syndromes and in the abnormal developmental Hirschsprung disease, whereas mutations of NTRK1 have been reported very recently in patients with congenital insensitivity to pain with anidrosis (CIPA).
Regulation (affected) of RET in germ line associated with pain, multiple endocrine neoplasia type 2a, congenital analgesia, multiple endocrine neoplasia type 2b, hirschsprung disease, syndrome and cancer
1) Confidence 0.52 Published 1996 Journal Oncogene Section Abstract Doc Link 8957089 Disease Relevance 0.77 Pain Relevance 0.09
RET is affected by germ line and somatic mutations in MEN2A, MEN2B tumor syndromes and in the abnormal developmental Hirschsprung disease, whereas mutations of NTRK1 have been reported very recently in patients with congenital insensitivity to pain with anidrosis (CIPA).
Regulation (affected) of MEN2A in germ line associated with pain, multiple endocrine neoplasia type 2a, congenital analgesia, multiple endocrine neoplasia type 2b, hirschsprung disease, syndrome and cancer
2) Confidence 0.44 Published 1996 Journal Oncogene Section Abstract Doc Link 8957089 Disease Relevance 0.78 Pain Relevance 0.09
Normal regulation of the RET protein, a tyrosine kinase receptor, is essential for the development of sympathetic neurons.
Regulation (regulation) of RET in neurons
3) Confidence 0.26 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.83 Pain Relevance 0.06
RET is affected by germ line and somatic mutations in MEN2A, MEN2B tumor syndromes and in the abnormal developmental Hirschsprung disease, whereas mutations of NTRK1 have been reported very recently in patients with congenital insensitivity to pain with anidrosis (CIPA).
Regulation (affected) of MEN2B in germ line associated with pain, multiple endocrine neoplasia type 2a, congenital analgesia, multiple endocrine neoplasia type 2b, hirschsprung disease, syndrome and cancer
4) Confidence 0.19 Published 1996 Journal Oncogene Section Abstract Doc Link 8957089 Disease Relevance 0.78 Pain Relevance 0.09
The plasma concentration of MMP2 was significantly higher in comparison to the control group whereas the concentrations of MMP1, TIMP1, TIMP2, and MTC1 were significantly lower from patients with non-metastasized TCC of the bladder in comparison to the healthy control group (Table I).
Regulation (concentrations) of MTC1 in bladder associated with transitional cell carcinoma
5) Confidence 0.12 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.65 Pain Relevance 0.19
The concentrations of TIMP1, TIMP2, and MTC1 in plasma probes were significantly lower from patients with non-metastasized TCC compared to the controls.
Regulation (concentrations) of MTC1 in plasma
6) Confidence 0.12 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1560390 Disease Relevance 0.35 Pain Relevance 0.03
In this study the concentrations of MMP1, MMP2, MMP3, MMP9, their inhibitors TIMP1, TIMP2, and the MMP1/TIMP1-complex (MTC1) were quantified in blood plasma with the sandwich enzyme-linked immunosorbent assay (ELISA).
Regulation (concentrations) of MTC1 in blood
7) Confidence 0.12 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1560390 Disease Relevance 0.44 Pain Relevance 0.13

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