INT66941

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.89
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
joints 1
endocrine cells 1
DRG 1
C cell 1
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 3 100.00 Very High Very High Very High
dorsal root ganglion 6 99.04 Very High Very High Very High
Inflammation 4 98.80 Very High Very High Very High
qutenza 1 98.80 Very High Very High Very High
Facet joint 4 98.32 Very High Very High Very High
Hsan 3 97.80 Very High Very High Very High
Action potential 1 96.76 Very High Very High Very High
Spinal cord 2 95.96 Very High Very High Very High
Lasting pain 1 94.96 High High
cINOD 2 90.80 High High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 175 100.00 Very High Very High Very High
Cancer 61 100.00 Very High Very High Very High
Ganglion Cysts 6 99.04 Very High Very High Very High
INFLAMMATION 6 98.80 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 3 97.80 Very High Very High Very High
Nociception 1 97.36 Very High Very High Very High
Cystitis 9 97.12 Very High Very High Very High
Diarrhoea 3 95.12 Very High Very High Very High
Pain 6 94.96 High High
Paraneoplastic Syndromes 1 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-localization of Trk neurotrophin receptors and regulatory peptides in the endocrine cells of the teleostean stomach.
Localization (Co-localization) of Trk in endocrine cells associated with neuropeptide
1) Confidence 0.78 Published 1999 Journal Anat. Rec. Section Title Doc Link 10521780 Disease Relevance 0 Pain Relevance 0.10
These results will be useful for studies on the developmental and biological regulation of the TRKA gene and for further characterization of mutations in CIPA patients as well as elucidation of mechanisms responsible for rearrangement(s) observed in human tumors.
Localization (regulation) of TRKA associated with cancer and hsan
2) Confidence 0.75 Published 1997 Journal Jpn. J. Hum. Genet. Section Abstract Doc Link 9290260 Disease Relevance 0.42 Pain Relevance 0.39
Genomic organization of the human NTRK1 gene.
Localization (organization) of NTRK1
3) Confidence 0.74 Published 1996 Journal Oncogene Section Title Doc Link 8957089 Disease Relevance 0.65 Pain Relevance 0.07
This study demonstrated the presence of NGF and TrkA in specimens collected from degenerative facet joints, suggesting that specific molecules could be used in order to modulate chronic pain in patients with degenerative lumbar spine.
Localization (presence) of TrkA in joints associated with facet joint and lasting pain
4) Confidence 0.49 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.67 Pain Relevance 0.52
The biological behavior and clinical presentation of MTC can be variable.
Localization (presentation) of MTC associated with thyroid neoplasm
5) Confidence 0.46 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 2.18 Pain Relevance 0
In the present study, we examined whether galectin-1 is colocalized with TrkA or c-Ret mRNA in small DRG neurons and the effect of axotomy on the expression of galectin-1 in the spinal cord.
Localization (colocalized) of TrkA in DRG associated with dorsal root ganglion and spinal cord
6) Confidence 0.18 Published 2003 Journal Brain Res. Section Abstract Doc Link 14642832 Disease Relevance 0.72 Pain Relevance 0.61
BACKGROUND: Medullary thyroid carcinoma (MTC) is a C cell neoplasm secreting calcitonin (CT).
Localization (secreting) of MTC in C cell associated with thyroid neoplasm and cancer
7) Confidence 0.18 Published 2009 Journal Thyroid Section Abstract Doc Link 19281427 Disease Relevance 0.65 Pain Relevance 0.17
Colocalization of p-CREB and Trk receptor(s) showed that a subpopulation of p-CREB-IR cells expressed p-Trk with cystitis.
Localization (Colocalization) of Trk receptor associated with cystitis
8) Confidence 0.00 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14694538 Disease Relevance 0.60 Pain Relevance 0.10

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