INT66941

Context Info Confidence 0.78 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 5.89 Pain Relevance 1.96

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)

Anatomy Link Frequency joints 1 endocrine cells 1 DRG 1 C cell 1 NTRK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropeptide 3 100.00 dorsal root ganglion 6 99.04 Inflammation 4 98.80 qutenza 1 98.80 Facet joint 4 98.32 Hsan 3 97.80 Action potential 1 96.76 Spinal cord 2 95.96 Lasting pain 1 94.96 cINOD 2 90.80

Disease Link Frequency Relevance Heat Thyroid Neoplasm 175 100.00 Cancer 61 100.00 Ganglion Cysts 6 99.04 INFLAMMATION 6 98.80 Hereditary Sensory And Autonomic Neuropathies 3 97.80 Nociception 1 97.36 Cystitis 9 97.12 Diarrhoea 3 95.12 Pain 6 94.96 Paraneoplastic Syndromes 1 94.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Co-localization of Trk neurotrophin receptors and regulatory peptides in the endocrine cells of the teleostean stomach.

Localization (Co-localization) of Trk in endocrine cells associated with neuropeptide

1) Confidence 0.78 Published 1999 Journal Anat. Rec. Section Title Doc Link 10521780 Disease Relevance 0 Pain Relevance 0.10

These results will be useful for studies on the developmental and biological regulation of the TRKA gene and for further characterization of mutations in CIPA patients as well as elucidation of mechanisms responsible for rearrangement(s) observed in human tumors.

Localization (regulation) of TRKA associated with cancer and hsan

2) Confidence 0.75 Published 1997 Journal Jpn. J. Hum. Genet. Section Abstract Doc Link 9290260 Disease Relevance 0.42 Pain Relevance 0.39

Genomic organization of the human NTRK1 gene.

Localization (organization) of NTRK1

3) Confidence 0.74 Published 1996 Journal Oncogene Section Title Doc Link 8957089 Disease Relevance 0.65 Pain Relevance 0.07

This study demonstrated the presence of NGF and TrkA in specimens collected from degenerative facet joints, suggesting that specific molecules could be used in order to modulate chronic pain in patients with degenerative lumbar spine.

Localization (presence) of TrkA in joints associated with facet joint and lasting pain

4) Confidence 0.49 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.67 Pain Relevance 0.52

The biological behavior and clinical presentation of MTC can be variable.

Localization (presentation) of MTC associated with thyroid neoplasm

5) Confidence 0.46 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 2.18 Pain Relevance 0

In the present study, we examined whether galectin-1 is colocalized with TrkA or c-Ret mRNA in small DRG neurons and the effect of axotomy on the expression of galectin-1 in the spinal cord.

Localization (colocalized) of TrkA in DRG associated with dorsal root ganglion and spinal cord

6) Confidence 0.18 Published 2003 Journal Brain Res. Section Abstract Doc Link 14642832 Disease Relevance 0.72 Pain Relevance 0.61

BACKGROUND: Medullary thyroid carcinoma (MTC) is a C cell neoplasm secreting calcitonin (CT).

Localization (secreting) of MTC in C cell associated with thyroid neoplasm and cancer

7) Confidence 0.18 Published 2009 Journal Thyroid Section Abstract Doc Link 19281427 Disease Relevance 0.65 Pain Relevance 0.17

Colocalization of p-CREB and Trk receptor(s) showed that a subpopulation of p-CREB-IR cells expressed p-Trk with cystitis.

Localization (Colocalization) of Trk receptor associated with cystitis

8) Confidence 0.00 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14694538 Disease Relevance 0.60 Pain Relevance 0.10

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