INT66986

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.43
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
brain 1
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 1 87.92 High High
Spinal cord 17 86.32 High High
alcohol 1 63.48 Quite High
Dopamine 160 50.00 Quite Low
isoflurane 2 43.44 Quite Low
anesthesia 4 42.56 Quite Low
Tetrahydrobiopterin 3 26.88 Quite Low
Nucleus accumbens 38 5.00 Very Low Very Low Very Low
Substantia nigra 31 5.00 Very Low Very Low Very Low
Ventral tegmentum 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 18 98.48 Very High Very High Very High
Parkinson's Disease 166 84.76 Quite High
Apoptosis 10 80.84 Quite High
Sprains And Strains 8 72.96 Quite High
Aggression 6 70.48 Quite High
Aging 9 67.52 Quite High
Disease 53 50.00 Quite Low
Death 18 50.00 Quite Low
Targeted Disruption 173 27.16 Quite Low
INFLAMMATION 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prenatal stress or corticosterone treatment have a lasting effect on typosine hydroxylase (TH) activity and adrenoligands binding in the mice brain.
TH Binding (binding) of in brain associated with stress
1) Confidence 0.45 Published 1996 Journal Fiziol Zh Im I M Sechenova Section Abstract Doc Link 8963333 Disease Relevance 0.27 Pain Relevance 0.09
Immunohistochemistry for c-Fos, pTH, TH, and pDARPP-32
pTH Binding (Immunohistochemistry) of
2) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0.27 Pain Relevance 0
Immunohistochemistry for c-Fos, pTH, TH, and pDARPP-32
TH Binding (Immunohistochemistry) of
3) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0.27 Pain Relevance 0
Finally, it remains to be determined the exact mechanism(s) whereby a-Syn mediates TH inhibition and whether it occurs by a direct interaction between a-Syn and TH or indirectly by a-Syn-mediated PP2A activation.
TH Neg (inhibition) Binding (inhibition) of
4) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.31 Pain Relevance 0
Finally, it remains to be determined the exact mechanism(s) whereby a-Syn mediates TH inhibition and whether it occurs by a direct interaction between a-Syn and TH or indirectly by a-Syn-mediated PP2A activation.
TH Binding (interaction) of
5) Confidence 0.24 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.31 Pain Relevance 0
The first aim of this study was to elucidate the effects of a-Syn on TH-Ser(P)-19, a site that contributes to 14-3-3 binding to TH.
TH Binding (binding) of
6) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
After blocking with a solution containing 5% nonfat milk, the filters were incubated with TH (1:1000 Boehringer-Mannheim, Indianapolis, IN) or ?
TH Binding (incubated) of
7) Confidence 0.20 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0 Pain Relevance 0.03
Louis, MO), ionized calcium binding adaptor molecule-1 (Iba1, 1:1000, Wako Chemicals USA, Richmond, VA), tyrosine hydroxylase (TH, 1:1000, Pel-Freez Biologicals, Rogers, AR), ?
tyrosine hydroxylase Binding (binding) of
8) Confidence 0.11 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04

General Comments

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