INT6699

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2004
Negated 0
Speculated 2
Reported most in Abstract
Documents 65
Total Number 67
Disease Relevance 22.72
Pain Relevance 20.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
plasma 5
radial 2
outflow 1
forearm 1
smooth muscle 1
ADRA1D (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 16 100.00 Very High Very High Very High
Glutamate 7 100.00 Very High Very High Very High
rapifen 15 99.90 Very High Very High Very High
Desipramine 7 99.78 Very High Very High Very High
Inflammation 27 99.62 Very High Very High Very High
agonist 30 99.52 Very High Very High Very High
Inflammatory mediators 3 99.52 Very High Very High Very High
Somatostatin 11 99.42 Very High Very High Very High
Hyperalgesia 3 99.38 Very High Very High Very High
withdrawal 5 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 19 99.90 Very High Very High Very High
Asthma 10 99.84 Very High Very High Very High
INFLAMMATION 22 99.62 Very High Very High Very High
Myocardial Infarction 17 99.62 Very High Very High Very High
Hyperalgesia 3 99.38 Very High Very High Very High
Opiate Addiction 3 99.32 Very High Very High Very High
Muscular Spasm 2 99.12 Very High Very High Very High
Diabetes Mellitus-type I 3 99.08 Very High Very High Very High
Stress Incontinence 4 99.04 Very High Very High Very High
Injury 14 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased alpha-adrenoceptor activation is a key candidate for the spasm.
Positive_regulation (activation) of alpha-adrenoceptor associated with muscular spasm
1) Confidence 0.70 Published 2001 Journal Eur. Heart J. Section Abstract Doc Link 11913483 Disease Relevance 0.20 Pain Relevance 0.13
These data also indicate that activation of endothelial alpha 1 -adrenergic receptors is mediated by a signal transduction mechanism associated with Gs protein.
Positive_regulation (activation) of alpha 1
2) Confidence 0.67 Published 1992 Journal Metab Brain Dis Section Abstract Doc Link 1331735 Disease Relevance 0.16 Pain Relevance 0.19
Activation of the alpha1 adrenoceptors by iontophoresis of methoxamine often led to a marked increase in the responses to kainic acid and, to a lesser extent, to NMDA iontophoresis or noxious heat.
Positive_regulation (Activation) of alpha1
3) Confidence 0.67 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9819240 Disease Relevance 0.77 Pain Relevance 0.80
The activation of alpha 1-adrenergic receptors leads to an increase in [Ca2+]i.
Positive_regulation (activation) of alpha 1
4) Confidence 0.67 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 2991734 Disease Relevance 0 Pain Relevance 0.20
Treatment with a number of drugs has also been shown to increase alpha 1-acid glycoprotein serum concentrations.
Positive_regulation (increase) of alpha 1
5) Confidence 0.67 Published 1986 Journal Clin Pharmacokinet Section Abstract Doc Link 3542337 Disease Relevance 1.00 Pain Relevance 0.14
The initial pressor response is due to activation of vascular alpha 1-adrenergic receptors while the hypotension and bradycardia are caused by the central actions of clonidine.
Positive_regulation (activation) of alpha 1 associated with heart rate under development, hypotension and clonidine
6) Confidence 0.67 Published 1987 Journal Brain Res. Section Abstract Doc Link 3676792 Disease Relevance 0.79 Pain Relevance 0.62
Patients with AMI had a significant increase in alpha-1-acid glycoprotein after 72 hours (mean 153 +/- 35 mg/dl) (p less than 0.05), and the maximum was observed on day 7 (mean 165 +/- 53 mg/dl) (p less than 0.05), returning to baseline by 28 days.
Positive_regulation (increase) of alpha-1 associated with myocardial infarction
7) Confidence 0.67 Published 1985 Journal Am. J. Cardiol. Section Abstract Doc Link 4025163 Disease Relevance 0.92 Pain Relevance 0.25
The unbound fraction of ropivacaine in plasma decreased during treatment, and this was related to the increase in alpha1-acid glycoprotein concentration.
Positive_regulation (increase) of alpha1 in plasma
8) Confidence 0.67 Published 1996 Journal Anesthesiology Section Body Doc Link 8638837 Disease Relevance 0 Pain Relevance 0
These increases were associated with increases in alpha 1-acid glycoprotein (AAG) concentration (uremic patients 134.9 mg/dl, control 66.3, P less than 0.001; transplant recipients 106.5, control 65.6, P less than 0.001).
Positive_regulation (increases) of alpha 1 associated with uremia
9) Confidence 0.67 Published 1982 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7037263 Disease Relevance 0.61 Pain Relevance 0.31
Patients with cancer had increased serum concentrations of the acute-phase protein alpha 1-acid glycoprotein (AAG) and lowered serum concentration of albumin.
Positive_regulation (increased) of alpha 1 associated with cancer
10) Confidence 0.67 Published 1982 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7105620 Disease Relevance 0.42 Pain Relevance 0.26
Neither prazosin (1 microM) nor tetrodotoxin (0.3 microM) significantly altered 5-HT-induced contraction, ruling out activation of alpha-1 adrenoceptors and sodium channels in the contractile response, respectively.
Positive_regulation (activation) of alpha-1 associated with tetrodotoxin and sodium channel
11) Confidence 0.67 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8423526 Disease Relevance 0 Pain Relevance 0.50
These findings suggest the following conclusions: 1) decongestion evoked by adrenergic agents is probably caused by direct activation of alpha-1 receptors, 2) decongestion of the middle and posterior portions is evoked by drug particles conveyed by ciliary movement, and 3) the contralateral response is probably related to the activation of sensory nerves on the ipsilateral side.
Positive_regulation (activation) of alpha-1 in ciliary
12) Confidence 0.67 Published 1994 Journal Nippon Jibiinkoka Gakkai Kaiho Section Abstract Doc Link 7529833 Disease Relevance 0 Pain Relevance 0.13
After ESWL there was an increase in urinary alpha 1-microglobulin and N-acetyl-beta-glucosaminidase, which was significantly higher in the control than in the verapamil group.
Positive_regulation (increase) of alpha 1
13) Confidence 0.67 Published 1993 Journal J. Urol. Section Abstract Doc Link 7685425 Disease Relevance 0.30 Pain Relevance 0.08
Procollagen alpha1(I) mRNA was markedly increased by week 2.
Positive_regulation (increased) of alpha1
14) Confidence 0.67 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10759232 Disease Relevance 0.82 Pain Relevance 0.27
Adherent AM organoids expressed increased levels of specific neural CAMs (NCAM and HNK-1 epitope) and integrin chains (beta1, alpha1, alpha2, alpha4, alpha5) and deposited markedly higher levels of fibronectin, but also laminin and collagen IV.
Positive_regulation (increased) of alpha1 in HNK-1
15) Confidence 0.67 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10833307 Disease Relevance 0.48 Pain Relevance 0.54
Alpha-1 acid glycoprotein levels were increased in patients and this effect was more pronounced in active disease (1802 +/- 1025 mg/l) than in remission (931 +/- 273 mg/l).
Positive_regulation (increased) of Alpha-1 associated with disease
16) Confidence 0.67 Published 1992 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 1473877 Disease Relevance 0.50 Pain Relevance 0.33
CONCLUSIONS: The results suggest that in the female rabbit in vivo activation of alpha1-adrenoceptors increased the urethral pressure.
Positive_regulation (activation) of alpha1
17) Confidence 0.67 Published 2000 Journal Scand. J. Urol. Nephrol. Section Body Doc Link 10961466 Disease Relevance 0.05 Pain Relevance 0
Noradrenaline dose-dependently stimulates phosphoinositide (PI) breakdown in both immature and mature cultures through the activation of alpha1 receptors.
Positive_regulation (activation) of alpha1 associated with noradrenaline
18) Confidence 0.67 Published 2001 Journal Cereb. Cortex Section Abstract Doc Link 11532892 Disease Relevance 0 Pain Relevance 0.38
These results suggest that an activation of alpha 1- or alpha 2-adrenoceptors would decrease the analgesic effect of EA.
Positive_regulation (activation) of alpha 1 associated with analgesic and electroacupuncture
19) Confidence 0.67 Published 1992 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 1364074 Disease Relevance 0.17 Pain Relevance 1.48
A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity.
Positive_regulation (increase) of alpha 1
20) Confidence 0.67 Published 1991 Journal Cor Vasa Section Abstract Doc Link 1655353 Disease Relevance 0.53 Pain Relevance 0.14

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