INT67

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 66
Total Number 68
Disease Relevance 15.34
Pain Relevance 28.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
medulla 6
brain 4
nucleus 3
central nervous system 2
hippocampus 2
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 214 100.00 Very High Very High Very High
antagonist 71 100.00 Very High Very High Very High
Catecholamine 55 100.00 Very High Very High Very High
monoamine 32 100.00 Very High Very High Very High
tetrodotoxin 25 100.00 Very High Very High Very High
Locus ceruleus 3 99.86 Very High Very High Very High
Rostral ventrolateral medulla 45 99.78 Very High Very High Very High
noradrenaline 24 99.68 Very High Very High Very High
Pain 80 99.64 Very High Very High Very High
Nucleus accumbens 22 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 33 100.00 Very High Very High Very High
Repression 2 100.00 Very High Very High Very High
Nervous System Injury 24 99.52 Very High Very High Very High
Disease 180 99.36 Very High Very High Very High
Peripheral Neuropathy 81 99.32 Very High Very High Very High
Hypertension 40 99.28 Very High Very High Very High
Injury 82 98.64 Very High Very High Very High
Hypotension 7 98.20 Very High Very High Very High
Hypoxia 5 97.16 Very High Very High Very High
Hyperalgesia 28 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonin synthesis, as estimated by the accumulation of 5-hydroxytryptophan 25 min following aromatic-L-amino acid decarboxylase inhibition, was measured in the medulla, pons-midbrain and posterior and anterior hypothalamus of rats subjected to left coronary artery ligation and their sham-operated controls.
Negative_regulation (inhibition) of aromatic-L-amino acid decarboxylase in medulla associated with medulla, midbrain and serotonin
1) Confidence 0.59 Published 1981 Journal Neurosci. Lett. Section Abstract Doc Link 7322452 Disease Relevance 0.07 Pain Relevance 0.45
Hippocampal serotonin (5-hydroxytryptamine, 5-HT) synthesis, as determined by the accumulation of 5-hydroxytryptophan (5-HTP) following inhibition of L-aromatic amino acid decarboxylase with NSD 1015, was inhibited by systemic administration of the selective serotonin reuptake inhibitors fluoxetine (10 mg/kg i.p.) and paroxetine (3 mg/kg i.p.).
Negative_regulation (inhibition) of L-aromatic amino acid decarboxylase associated with ssri, serotonin and fluoxetine
2) Confidence 0.59 Published 1999 Journal Synapse Section Abstract Doc Link 10025679 Disease Relevance 0 Pain Relevance 0.40
After inhibition of the peripheral L-aminoacid decarboxylase with MK-486, L-DOPA caused the same reduction of survival time during hypoxia as after L-DOPA alone.
Negative_regulation (inhibition) of peripheral L-aminoacid decarboxylase associated with hypoxia
3) Confidence 0.59 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 6980559 Disease Relevance 0.35 Pain Relevance 0.36
Experiments on alert rats have shown that, with pre-inhibition of peripheral DOPA-decarboxylase, L-DOPA suppresses behavioral nociceptive reactions without changing hemodynamic ones.
Negative_regulation (inhibition) of DOPA-decarboxylase associated with nociception
4) Confidence 0.59 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2998505 Disease Relevance 0.10 Pain Relevance 0.07
This enhancement seems to include partially a decrease in decarboxylation of L-DOPA, since L-aromatic amino acid decarboxylase activity was decreased in spontaneously hypertensive rats compared to Wistar-Kyoto rats, while no difference in tyrosine hydroxylase activity was seen.
Negative_regulation (decreased) of L-aromatic amino acid decarboxylase associated with hypertension
5) Confidence 0.58 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477914 Disease Relevance 1.11 Pain Relevance 0.29
The effects of fentanyl, droperidol, and morphine on tyrosine hydroxylation in the rat striatum was measured after inhibition of aromatic amino acid decarboxylase with R04-4602.
Negative_regulation (inhibition) of aromatic amino acid decarboxylase in striatum associated with morphine
6) Confidence 0.58 Published 1976 Journal Exp Brain Res Section Abstract Doc Link 1010005 Disease Relevance 0 Pain Relevance 0.18
The restoration by 5-hydroxytryptophan was prevented by the inhibitor of L-aminoacid decarboxylase, benserazide.
Negative_regulation (inhibitor) of L-aminoacid decarboxylase
7) Confidence 0.57 Published 1982 Journal Neuroscience Section Abstract Doc Link 6210850 Disease Relevance 0 Pain Relevance 0.17
Two approaches are used in Sprague-Dawley rat to measure the activation of serotonergic neurons: (1) determination ex vivo of accumulation of 5-hydroxytryptophan (5-HTP) in tissue from the dorsal and median raphe nuclei, hippocampus, cortex, caudate nucleus, and nucleus accumbens following in vivo inhibition of aromatic amino acid decarboxylase; and (2) measurement of extracellular serotonin levels in hippocampus, caudate nucleus, and nucleus accumbens.
Negative_regulation (inhibition) of aromatic amino acid decarboxylase in nucleus accumbens associated with nucleus accumbens, hippocampus, serotonin and raphe
8) Confidence 0.57 Published 2001 Journal Brain Res. Section Abstract Doc Link 11743977 Disease Relevance 0.33 Pain Relevance 1.18
The hypothalamic nuclei of the alcohol-preferring AA rats contained slightly more serotonin than those of the alcohol-avoiding ANA rats, but the accumulation of 5-hydroxytryptophan after inhibition of aromatic amino acid decarboxylase was the same in both lines.
Negative_regulation (inhibition) of aromatic amino acid decarboxylase associated with serotonin and alcohol
9) Confidence 0.56 Published 1991 Journal Alcohol Section Abstract Doc Link 1829611 Disease Relevance 0.11 Pain Relevance 0.64
An inhibitor of aromatic amino acid decarboxylase, NSD-1015, was administered through the dialysis probe and the resulting accumulation of 3,4-dihydroxyphenylalanine (DOPA) in extracellular fluid of hippocampus was quantified.
Negative_regulation (inhibitor) of aromatic amino acid decarboxylase in hippocampus associated with hippocampus
10) Confidence 0.53 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1345767 Disease Relevance 0.06 Pain Relevance 0.24
The purpose of this study was to determine if 5-HT is synthesized in neurons of the neurointermediate lobe of the pituitary gland. 5-HT synthesis was estimated by measuring the accumulation of the 5-HT precursor, 5-hydroxytryptophan (5-HTP), in the neurointermediate lobe of male Long-Evans rats following the administration of NSD 1015, an inhibitor of aromatic L-amino acid decarboxylase.
Negative_regulation (inhibitor) of L-amino acid decarboxylase in lobe
11) Confidence 0.51 Published 1987 Journal Brain Res. Section Abstract Doc Link 3103858 Disease Relevance 0 Pain Relevance 0.07
For this purpose, 5-hydroxytryptophan (5-HTP) accumulation was determined using an HPLC-ECD system in the presence of the inhibition of aromatic L-amino acid decarboxylase.
Negative_regulation (inhibition) of L-amino acid decarboxylase
12) Confidence 0.51 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1357604 Disease Relevance 0 Pain Relevance 0.55
The effect of the lesions was to selectively decrease the tissue content of L-DOPA by one-half in the right rostral ventrolateral medulla.
Negative_regulation (decrease) of L-DOPA in medulla associated with rostral ventrolateral medulla
13) Confidence 0.51 Published 1999 Journal Neuroscience Section Abstract Doc Link 10392836 Disease Relevance 0 Pain Relevance 0.57
In rats with partial, unilateral lesions of the dopaminergic nigrostriatal pathway, synthesis of dopamine (DA) per surviving neurone was assessed by measuring the ratio of DOPA accumulated after inhibition of aromatic amino acid decarboxylase to dopamine (DOPA/DA ratio).
Negative_regulation (inhibition) of aromatic amino acid decarboxylase associated with dopamine
14) Confidence 0.50 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.47
On the basis of biochemical indices of dopamine (DA) nerve activity (decline of DA after inhibition of tyrosine hydroxylase, accumulation of DOPA after inhibition of DOPA decarboxylase) it was revealed that morphine increases the activity of nigrostriatal and mesolimbic DA nerves which terminate in the striatum, nucleus accumbens and olfactory tubercle, but reduce the activity of tuberoinfundibular DA nerves which terminate in the median eminence.
Negative_regulation (inhibition) of DOPA decarboxylase in nerves associated with nucleus accumbens, dopamine and morphine
15) Confidence 0.48 Published 1980 Journal J. Neural Transm. Section Abstract Doc Link 6772740 Disease Relevance 0 Pain Relevance 0.81
However, this treatment altered neither the levels of 5-hydroxyindoleacetic acid nor the accumulation of 5-hydroxytryptophan after blockade of aromatic L-amino acid decarboxylase.
Negative_regulation (blockade) of L-amino acid decarboxylase
16) Confidence 0.47 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11770008 Disease Relevance 0 Pain Relevance 1.08
Biochemical estimations of changes in 5-HT neuronal activity were made by measuring: (1) concentrations of 5-HT and 5-HIAA and (2) the rate of 5-HT synthesis (5-HTP accumulation following the administration of NSD 1015, an inhibitor of aromatic L-amino acid decarboxylase) after the administration of pharmacological agents known to influence these neurons.
Negative_regulation (inhibitor) of L-amino acid decarboxylase in neuronal
17) Confidence 0.46 Published 1983 Journal J. Neural Transm. Section Abstract Doc Link 6619830 Disease Relevance 0.09 Pain Relevance 0.06
A peripheral inhibitor of L-aromatic amino acid decarboxylase, carbidopa [(-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate], at doses up to 25 mg/kg intraperitoneally or 30 mg/kg orally had no effect on directly recorded arterial pressure of spontaneously hypertensive rats derived from the Wistar/Okamoto strain.
Negative_regulation (inhibitor) of L-aromatic amino acid decarboxylase associated with hypertension and sprains and strains
18) Confidence 0.43 Published 1976 Journal Clin Sci Mol Med Suppl Section Abstract Doc Link 1071655 Disease Relevance 0.48 Pain Relevance 0.10
The following compounds, alone or in various combinations, failed to restore atropine-resistant LVFA in reserpinized rats even though spontaneous motor activity was restored in many cases: L-DOPA (150-300 mg/kg) after pretreatment with an inhibitor of peripheral L-aromatic amino acid decarboxylase; 5-hydroxytryptophan (100-200 mg/kg); D-amphetamine (1-2 mg/kg); apomorphine (0.25-2.5 mg/kg); lysergic acid diethylamide (100-300 microgram/kg); and clonidine (0.5-1.0 mg/kg).
Negative_regulation (inhibitor) of L-aromatic amino acid decarboxylase associated with clonidine
19) Confidence 0.43 Published 1980 Journal Brain Res. Section Abstract Doc Link 6968619 Disease Relevance 0 Pain Relevance 0.29
The formation of DOPA and 5-HTP in various parts of the central nervous system during 30 min after inhibition of L-amino-acid-decarboxylase by NSD 1015 was measured.
Negative_regulation (inhibition) of L-amino-acid-decarboxylase in central nervous system associated with central nervous system
20) Confidence 0.43 Published 1982 Journal J. Neural Transm. Section Abstract Doc Link 6122716 Disease Relevance 0.09 Pain Relevance 0.74

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox