INT670

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Context Info
Confidence 0.66
First Reported 1978
Last Reported 2008
Negated 2
Speculated 1
Reported most in Abstract
Documents 31
Total Number 33
Disease Relevance 27.32
Pain Relevance 8.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (B2m)
Anatomy Link Frequency
plasma 5
CSF 3
joint 2
sieve 2
pancreas 1
B2m (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 21 99.98 Very High Very High Very High
Multiple sclerosis 42 99.84 Very High Very High Very High
Inflammation 91 99.80 Very High Very High Very High
Pain 9 99.80 Very High Very High Very High
headache 21 99.60 Very High Very High Very High
Chronic pancreatitis 3 99.44 Very High Very High Very High
cytokine 41 99.28 Very High Very High Very High
Inflammatory response 19 98.88 Very High Very High Very High
carpal tunnel syndrome 21 98.64 Very High Very High Very High
rheumatoid arthritis 5 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Amyloidosis 43 100.00 Very High Very High Very High
Alzheimer's Dementia 25 100.00 Very High Very High Very High
Amyloid Plaque 2 99.96 Very High Very High Very High
Syndrome 3 99.90 Very High Very High Very High
INFLAMMATION 114 99.84 Very High Very High Very High
Demyelinating Disease 42 99.84 Very High Very High Very High
Pain 2 99.80 Very High Very High Very High
Arthralgia 12 99.76 Very High Very High Very High
Disease Susceptibility 8 99.66 Very High Very High Very High
Headache 21 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rheumatic syndromes and beta 2-microglobulin amyloidosis in patients receiving long-term peritoneal dialysis.
Gene_expression (amyloidosis) of beta 2-microglobulin associated with amyloidosis, renal failure and syndrome
1) Confidence 0.66 Published 1989 Journal Arthritis Rheum. Section Title Doc Link 2660798 Disease Relevance 1.08 Pain Relevance 0.17
Some genes related to the inflammatory response, such as Cxcl10, Clu and antigen presentation, such as B2m, Fcer1g showed over-expression only at 72 and 96 hr post infection (Fig 2).
Gene_expression (over) of B2m associated with inflammatory response and infection
2) Confidence 0.64 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 0.90 Pain Relevance 0.05
Selecting plasma beta2-microglobulin (beta2-M) as a marker, a prospective study on the long-term clinical effect of a beta2-M-removable membrane (PMMA BK membrane) has been performed and the changes in joint pains and plasma beta2-M have been followed for 5 years.
Gene_expression (Selecting) of beta2-M in plasma associated with arthralgia
3) Confidence 0.63 Published 1995 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 8570083 Disease Relevance 0.39 Pain Relevance 0.21
Selecting plasma beta2-microglobulin (beta2-M) as a marker, a prospective study on the long-term clinical effect of a beta2-M-removable membrane (PMMA BK membrane) has been performed and the changes in joint pains and plasma beta2-M have been followed for 5 years.
Gene_expression (Selecting) of beta2-microglobulin in plasma associated with arthralgia
4) Confidence 0.63 Published 1995 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 8570083 Disease Relevance 0.38 Pain Relevance 0.21
The circulating profile of beta-2-microglobulin (beta 2M) was determined in 8 end-stage renal disease patients on long-term dialysis (6 on hemodialysis, 2 on CAPD) by measuring beta 2M in different fraction after molecular sieve separation of their sera.
Spec (determined) Gene_expression (profile) of beta 2M in sieve associated with renal failure and renal disease
5) Confidence 0.62 Published 1988 Journal Am. J. Nephrol. Section Abstract Doc Link 3071144 Disease Relevance 0.36 Pain Relevance 0.08
The circulating profile of beta-2-microglobulin (beta 2M) was determined in 8 end-stage renal disease patients on long-term dialysis (6 on hemodialysis, 2 on CAPD) by measuring beta 2M in different fraction after molecular sieve separation of their sera.
Gene_expression (profile) of beta-2-microglobulin in sieve associated with renal failure and renal disease
6) Confidence 0.62 Published 1988 Journal Am. J. Nephrol. Section Abstract Doc Link 3071144 Disease Relevance 0.35 Pain Relevance 0.08
Only 3 patients with carcinoma of the pancreas exhibited serum levels within the normal range for both parameters and none of the patients with chronic pancreatitis was shown to have elevated levels of beta2m.
Gene_expression (levels) of beta2m in pancreas associated with carcinoma and chronic pancreatitis
7) Confidence 0.57 Published 1978 Journal Klin. Wochenschr. Section Abstract Doc Link 76694 Disease Relevance 0.80 Pain Relevance 0.28
Four patients had carpal tunnel syndrome with demonstrated amyloid in excised wrist tissues of which 2 were positive for beta 2M.
Gene_expression (positive) of beta 2M in wrist associated with alzheimer's dementia and carpal tunnel syndrome
8) Confidence 0.54 Published 1988 Journal Am. J. Nephrol. Section Abstract Doc Link 3071144 Disease Relevance 0.38 Pain Relevance 0.10
In the absence of beta2m, B*2702 is not detected on the cell membrane, nor does it increase the risk for ANKENT.
Neg (absence) Gene_expression (absence) of beta2m
9) Confidence 0.54 Published 1997 Journal Immunogenetics Section Abstract Doc Link 9148786 Disease Relevance 0.89 Pain Relevance 0.08
Amyloidosis containing beta 2 microglobulin (beta 2m) and joint pains are frequent complications of long-term hemodialysis.
Gene_expression (containing) of beta 2 microglobulin in joint associated with arthralgia and amyloidosis
10) Confidence 0.52 Published 1988 Journal Clin. Rheumatol. Section Abstract Doc Link 3044672 Disease Relevance 0.80 Pain Relevance 0
Amyloidosis containing beta 2 microglobulin (beta 2m) and joint pains are frequent complications of long-term hemodialysis.
Gene_expression (containing) of beta 2m in joint associated with arthralgia and amyloidosis
11) Confidence 0.52 Published 1988 Journal Clin. Rheumatol. Section Abstract Doc Link 3044672 Disease Relevance 0.81 Pain Relevance 0.05
Some genes related to the inflammatory response, such as Cxcl10, Clu and antigen presentation, such as B2m, Fcer1g showed over-expression only at 72 and 96 hr post infection (Fig 2).
Gene_expression (expression) of B2m associated with inflammatory response and infection
12) Confidence 0.49 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 0.90 Pain Relevance 0.05
In contrast, when HLA-B*2702 is expressed with beta2m of human origin, disease susceptibility is not affected.
Gene_expression (expressed) of beta2m associated with disease susceptibility
13) Confidence 0.47 Published 1997 Journal Immunogenetics Section Abstract Doc Link 9148786 Disease Relevance 0.81 Pain Relevance 0.06
Rather, in order to increase disease susceptibility, B*2702 must be coexpressed with mouse beta2m (mo-beta2m).
Gene_expression (coexpressed) of beta2m associated with disease susceptibility
14) Confidence 0.47 Published 1997 Journal Immunogenetics Section Abstract Doc Link 9148786 Disease Relevance 0.83 Pain Relevance 0.07
Rather, in order to increase disease susceptibility, B*2702 must be coexpressed with mouse beta2m (mo-beta2m).
Gene_expression (coexpressed) of beta2m associated with disease susceptibility
15) Confidence 0.47 Published 1997 Journal Immunogenetics Section Abstract Doc Link 9148786 Disease Relevance 0.83 Pain Relevance 0.07
[Inflammatory cell infiltration around beta 2-microglobulin amyloid deposition: histologic comparison of beta 2-microglobulin amyloidosis with AA or AL amyloidosis].
Gene_expression (deposition) of beta 2-microglobulin associated with amyloidosis, inflammation and alzheimer's dementia
16) Confidence 0.46 Published 1992 Journal Nippon Jinzo Gakkai Shi Section Title Doc Link 1479708 Disease Relevance 1.66 Pain Relevance 0.16
The class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin [B2M]) and is expressed by all nucleated cells.
Gene_expression (expressed) of microglobulin
17) Confidence 0.35 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.11 Pain Relevance 0.09
The class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin [B2M]) and is expressed by all nucleated cells.
Gene_expression (expressed) of B2M
18) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.11 Pain Relevance 0.08
Antigen presentation (B2M, HLA-A, HLA-DQA1, HLA-DQB2, HLA-E, HLA-G, IGHG, and IGH)
Gene_expression (presentation) of B2M
19) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.26 Pain Relevance 0.19
Serum beta2m levels were not related with the occurrence of DRA.
Gene_expression (levels) of beta2m associated with amyloidosis
20) Confidence 0.26 Published 1998 Journal Nephron Section Abstract Doc Link 9546683 Disease Relevance 1.27 Pain Relevance 0.35

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