INT67002

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.43
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
narcan 7 99.98 Very High Very High Very High
gABA 7 99.80 Very High Very High Very High
nMDA receptor antagonist 1 99.22 Very High Very High Very High
Substantia nigra 7 98.12 Very High Very High Very High
Neurotransmitter 1 83.80 Quite High
Dopamine 8 82.76 Quite High
Glutamate 3 79.12 Quite High
opioid receptor 2 60.56 Quite High
Disease Link Frequency Relevance Heat
Dyskinesias 5 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following treatment of the non-competitive NMDA receptor antagonist dizocilpine (MK-801), the LID-induced changes in PDyn mRNA, phospho-Thr-34 DARPP-32 and phospho-Thr-75 DARPP-32 were largely reversed.
Negative_regulation (reversed) of Regulation (changes) of PDyn mRNA associated with nmda receptor antagonist and dyskinesias
1) Confidence 0.43 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17884291 Disease Relevance 0.43 Pain Relevance 0.09
Naloxone blocked the effect of systemic morphine administration on nigral dynorphin B and GABA release, already at a dose of 0.2 mg/kg s.c.
Negative_regulation (blocked) of Regulation (effect) of dynorphin B associated with gaba, dynorphin, narcan and morphine
2) Confidence 0.35 Published 1996 Journal Brain Res. Section Abstract Doc Link 8963665 Disease Relevance 0 Pain Relevance 2.11

General Comments

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