INT67038

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Context Info
Confidence 0.08
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.61
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
liver 2
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 99.90 Very High Very High Very High
Duloxetine 134 99.36 Very High Very High Very High
Gabapentin 14 89.28 High High
tolerance 3 87.84 High High
antagonist 3 77.04 Quite High
Inflammatory response 1 58.08 Quite High
backache 1 53.88 Quite High
Lamotrigine 7 53.76 Quite High
carbamazepine 7 53.24 Quite High
headache 8 53.16 Quite High
Disease Link Frequency Relevance Heat
Pain 3 99.90 Very High Very High Very High
Hyperbilirubinemia 2 99.60 Very High Very High Very High
Disease 18 99.00 Very High Very High Very High
Congenital Anomalies 9 98.04 Very High Very High Very High
Dizziness 7 96.16 Very High Very High Very High
Sleep Disorders 12 95.56 Very High Very High Very High
Fatigue 4 94.68 High High
Skin Appendage Disease 3 94.32 High High
Hepatotoxicity 3 90.00 High High
Death 8 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In consecutive administration, however, mild bone pain and increased serum alkaline phosphatase were observed in about half the patients, but neither accumulation of rhG-CSF nor antibody production was detected.
Neg (neither) Positive_regulation (accumulation) of Positive_regulation (increased) of alkaline phosphatase associated with pain
1) Confidence 0.08 Published 1995 Journal Artif Organs Section Abstract Doc Link 8967884 Disease Relevance 0.24 Pain Relevance 0.10
Short-term treatment with duloxetine has been associated with small increases in liver enzyme values.50 Alkaline phosphatase, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were all increased compared to placebo-treated patients.
Positive_regulation (increases) of Positive_regulation (increases) of Alkaline phosphatase in liver associated with duloxetine
2) Confidence 0.05 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846146 Disease Relevance 0.90 Pain Relevance 0.37
They also demonstrated that cycloheximide, a well known protein synthesis inhibitor, prevented the quercetin-induced ALP activation, indicating that de novo protein synthesis is essential for this response.
Positive_regulation (induced) of Positive_regulation (activation) of ALP
3) Confidence 0.05 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2685048 Disease Relevance 0.11 Pain Relevance 0.07
The most frequent abnormal LFT was elevated ALT (36.7%), followed by elevated alkaline phosphatase (16.9%), hyperbilirubinemia (9.6%) and elevated AST (9.0%).
Positive_regulation (elevated) of Positive_regulation (elevated) of alkaline phosphatase associated with hyperbilirubinemia
4) Confidence 0.05 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902446 Disease Relevance 0.82 Pain Relevance 0.23
There was no excess of increased elevations of alkaline phosphatase or bilirubin levels in the patients who received Cilengitide and gemcitabine in comparison with gemcitabine alone.
Positive_regulation (increased) of Positive_regulation (elevations) of alkaline phosphatase
5) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1764757 Disease Relevance 0.54 Pain Relevance 0

General Comments

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