INT67060

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.94
Pain Relevance 5.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
plasma 4
blood 2
lymphocytes 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 244 100.00 Very High Very High Very High
cytokine 160 100.00 Very High Very High Very High
Morphine 10 99.98 Very High Very High Very High
melanocortin 1 receptor 9 98.80 Very High Very High Very High
Central nervous system 4 98.08 Very High Very High Very High
Inflammatory response 20 97.60 Very High Very High Very High
Arthritis 30 97.52 Very High Very High Very High
vagus nerve 6 92.36 High High
rheumatoid arthritis 50 89.40 High High
acular 2 88.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 295 100.00 Very High Very High Very High
Adhesions 18 100.00 Very High Very High Very High
Targeted Disruption 6 100.00 Very High Very High Very High
Myocarditis 3 99.90 Very High Very High Very High
Toxicity 16 99.24 Very High Very High Very High
Acid Reflux 18 99.18 Very High Very High Very High
Cancer 64 98.76 Very High Very High Very High
Acute Myocarditis 30 98.62 Very High Very High Very High
Juvenile Chronic Polyarthritis 1 97.52 Very High Very High Very High
Shock 4 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, morphine inhibited expression of TNF-alpha mRNA in BALB/3T3 cells (IC50, 1.6 mM), but not expression of early response genes.
Negative_regulation (inhibited) of Transcription (expression) of TNF-alpha associated with morphine
1) Confidence 0.59 Published 1996 Journal Carcinogenesis Section Abstract Doc Link 8968046 Disease Relevance 1.13 Pain Relevance 0.83
It has been demonstrated that thalidomide selectively inhibits the TNF-alpha and IL-6 mRNA expression in human peripheral blood mononuclear cells [10].
Negative_regulation (inhibits) of Transcription (expression) of TNF-alpha in blood
2) Confidence 0.52 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2831027 Disease Relevance 1.24 Pain Relevance 0.30
When IL-6 binds to its receptor, a mechanism is triggered blocking Janus Kinase signal and activator of transcription (JAK/STAT) mediated transcription of IL-1 and TNF-?
Negative_regulation (blocking) of Transcription (transcription) of TNF
3) Confidence 0.42 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 0.68 Pain Relevance 0.41
We previously reported that in a rat model of mixed reflux esophagitis, intraduodenal rebamipide significantly inhibited the increased expression of mRNA and protein for CINC-1 and TNF-?
Negative_regulation (inhibited) of Transcription (expression) of TNF associated with acid reflux
4) Confidence 0.41 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.88 Pain Relevance 0.44
For instance, KGF upregulates the transcription factor Nrf 2 that encodes genes playing a role in detoxifying radical oxygen species (Braun et al 2002; auf dem Keller et al 2004), attenuating TNF-?
Negative_regulation (attenuating) of Transcription (transcription) of TNF
5) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.58 Pain Relevance 0.11
In return, IL-6 inhibits the transcription of TNF-?
Negative_regulation (inhibits) of Transcription (transcription) of TNF
6) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3022197 Disease Relevance 0.98 Pain Relevance 0.46
Indeed, these transcripts covered such diverse proteins and functions as: ribosomal components (LAMR1, MRPL22, RPL35, RPS16, RPS28), which may suggest the existence of a TNF?
Negative_regulation (suggest) of Transcription (existence) of TNF
7) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779405 Disease Relevance 0.17 Pain Relevance 0
In addition, the levels of TNF-alpha, IL-6, and IL-1beta mRNA expression in FLS cells induced by a TNF-alpha and IL-1beta co-treatment were largely inhibited by a KTBE treatment.
Negative_regulation (inhibited) of Transcription (expression) of TNF-alpha
8) Confidence 0.38 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 19023550 Disease Relevance 0.26 Pain Relevance 0.29
Among the tested compounds, shikonin and isobutyryl shikonin exhibited the highest inhibition of TNF-alpha promoter activation and also showed significant suppression of transgenic human TNF-alpha mRNA expression and protein production.
Negative_regulation (suppression) of Transcription (expression) of TNF-alpha associated with targeted disruption
9) Confidence 0.37 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.63 Pain Relevance 0.13
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Negative_regulation (decreased) of Transcription (transcription) of TNF-alpha associated with melanocortin 1 receptor
10) Confidence 0.35 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.34 Pain Relevance 0.87
RU was shown to inhibit the transcription of more than 20 genes encoding critical proinflammatory factors, including TNF-?
Negative_regulation (inhibit) of Transcription (transcription) of TNF
11) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.86 Pain Relevance 0.38
Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects.
Negative_regulation (relative) of Transcription (expression) of tumor necrosis factor in plasma
12) Confidence 0.07 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.09 Pain Relevance 0
Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects.
Negative_regulation (relative) of Transcription (expression) of TNF in plasma
13) Confidence 0.07 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.09 Pain Relevance 0
Intraperitoneal administration of recombinant human IL-10 into mice with experimental viral myocarditis appeared to improve survival, attenuate myocardial inflammation and decrease the myocardial mRNA expression of TNF- alpha, IL-2, and inducible NO synthase [9].
Negative_regulation (decrease) of Transcription (expression) of TNF associated with myocarditis, inflammation and acute myocarditis
14) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 1.96 Pain Relevance 0.48
As described above, TNF-?
Negative_regulation (above) of Transcription (described) of TNF
15) Confidence 0.05 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.67 Pain Relevance 0.07
The interaction between allogenic blood lymphocytes and vascular endothelial cells is correlated with high expression of mRNA of both adhesion molecules and TNF-?
Negative_regulation (high) of Transcription (expression) of TNF in lymphocytes associated with adhesions
16) Confidence 0.04 Published 2005 Journal Crit Care Section Body Doc Link PMC1065100 Disease Relevance 0.98 Pain Relevance 0.18
The inhibitory effect was associated with decreased levels of the pro-inflammatory cytokine, TNF [5,7].
Negative_regulation (decreased) of Transcription (levels) of TNF associated with inflammation and cytokine
17) Confidence 0.04 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 1.39 Pain Relevance 0.93

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