INT67093

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.32
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CASR) signal transducer activity (CASR)
Anatomy Link Frequency
parathyroid 1
CASR (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 1 99.78 Very High Very High Very High
Chronic pancreatitis 39 98.44 Very High Very High Very High
backache 1 90.64 High High
Thoracotomy 3 42.24 Quite Low
Lasting pain 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 7 100.00 Very High Very High Very High
Arthritis 1 99.78 Very High Very High Very High
Pancreatitis 69 98.44 Very High Very High Very High
Hypercalcemia 60 95.12 Very High Very High Very High
Low Back Pain 1 90.64 High High
Pressure And Volume Under Development 4 88.80 High High
Renal Failure 2 82.80 Quite High
Arthropathy 1 75.00 Quite High
Parathyroid Cancer 34 72.72 Quite High
Cancer 12 69.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Distinct forms of arthritis have been associated with HHC and may be the initial clinical manifestation in some patients.
HHC Binding (associated) of associated with iron overload and arthritis
1) Confidence 0.41 Published 1996 Journal Am. J. Med. Sci. Section Abstract Doc Link 8969622 Disease Relevance 0.89 Pain Relevance 0.14
However, our observation of an individual with a combination of heterozygous SPINK1 (N34S) and CASR gene (L173P) mutations, who developed chronic pancreatitis, may indicate the specific pathogenetic background of CP within this family.
CASR Binding (combination) of associated with chronic pancreatitis
2) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.34 Pain Relevance 0.50
Cinacalcet is a calcimimetic, which reduces parathyroid hormone secretion by binding to the calcium-sensing receptor on parathyroid cells, increasing the sensitivity of these cells to extracellular calcium concentrations [15, 30, 31].
calcium-sensing receptor Binding (binding) of in parathyroid
3) Confidence 0.08 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 1.09 Pain Relevance 0

General Comments

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