INT67097

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 21.06
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MIB1) ligase activity (MIB1) cytoplasm (MIB1)
Anatomy Link Frequency
endothelial cells 1
smooth muscle 1
crescent 1
MIB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 11 96.24 Very High Very High Very High
dexamethasone 1 82.16 Quite High
cINOD 2 79.44 Quite High
headache 7 76.56 Quite High
palliative 3 76.48 Quite High
fibrosis 5 76.40 Quite High
imagery 43 75.00 Quite High
Angina 1 72.92 Quite High
Inflammation 78 70.40 Quite High
Catecholamine 9 59.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 419 99.90 Very High Very High Very High
Meningioma 9 99.84 Very High Very High Very High
Necrosis 28 99.74 Very High Very High Very High
Pilomatrixoma 14 99.68 Very High Very High Very High
Inflammatory Breast Neoplasms 270 99.46 Very High Very High Very High
Malignant Neoplastic Disease 57 99.04 Very High Very High Very High
Malignant Fibrous Histiocytoma 5 98.88 Very High Very High Very High
Follicular Lymphoma 12 98.76 Very High Very High Very High
Adenoma 19 98.52 Very High Very High Very High
Metastasis 54 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study the relationship between pathodiagnostic parameters, histological grade, and MIB-1 monoclonal antibody expression in meningioma diagnosed over 10 years in Shohada Hospital, Tehran, was assessed.
Gene_expression (expression) of MIB-1 associated with meningioma
1) Confidence 0.75 Published 2008 Journal J Clin Neurosci Section Abstract Doc Link 18819804 Disease Relevance 0.72 Pain Relevance 0
MIB1 indices (number of MIB1 positive tumor cells/1000 tumor cells evaluated x 100) ranged from 0 to 4.3 (mean 0.7); in five tumors, no MIB1 staining was observed. p53 immunoreactivity was noted in 5 of 18 tumors (28%).
Gene_expression (staining) of MIB1 associated with cancer
2) Confidence 0.59 Published 1996 Journal Pathol. Int. Section Abstract Doc Link 8970195 Disease Relevance 1.98 Pain Relevance 0.08
MIB-1 antibody against Ki-67 was found negative in the ductal, acinoductular and islet cells reflecting low proliferation in these cells.
Neg (negative) Gene_expression (negative) of MIB-1
3) Confidence 0.58 Published 2004 Journal Hepatogastroenterology Section Body Doc Link 15011837 Disease Relevance 0.08 Pain Relevance 0
The tumors were classified as low and high grade on the basis of their cellular differentiation, mitotic count, tumor necrosis [15,16] and expression of MIB-1 proliferation marker [17,18].
Gene_expression (expression) of MIB-1 associated with necrosis and cancer
4) Confidence 0.45 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1560134 Disease Relevance 1.58 Pain Relevance 0.06
Although several markers such as immunohistochemical expression of the cell proliferation marker Ki-67/MIB-1, telomerase activity, hTERT expression, topoisomerase IIa expression, and mRNA expression of MMP-2 and EMMPRIN metalloproteinases have shown promising results, they need further evaluation.
Gene_expression (expression) of MIB-1 associated with metalloproteinase
5) Confidence 0.42 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 1.19 Pain Relevance 0.19
Five variables were significantly associated with IBC in multivariate analysis: MIB1, ERBB2 and E-cadherin overexpression, ER negativity, and MUC1 cytoplasmic staining.
Gene_expression (overexpression) of MIB1 associated with inflammatory breast neoplasms
6) Confidence 0.41 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.51 Pain Relevance 0.03
The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.
Neg (negative) Gene_expression (negative) of MIB-1 in smooth muscle
7) Confidence 0.40 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.85 Pain Relevance 0.07
In a recent immunophenotypic study of 80 IBC patients compared with 552 non-IBC controls, tissue arrays were used to determine the protein expression of ER, progesterone receptor, EGFR and ERBB2, MIB1, P53, MUC1 and E-cadherin [12].
Spec (determine) Gene_expression (expression) of MIB1 associated with inflammatory breast neoplasms
8) Confidence 0.32 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.56 Pain Relevance 0.04
Fayyazi and colleagues have assessed expression of the cell proliferation associated antigen Ki 67 (MIB1) in 15 pilomatrixomas [11].
Gene_expression (expression) of MIB1 associated with pilomatrixoma
9) Confidence 0.29 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2633279 Disease Relevance 1.52 Pain Relevance 0
As expected, some amplified genes (MEMO1, IGFP6, TBK1, MIB1, RIOK3), determined by the DNA chip array demonstrated high level of RNA overexpression as well.


Gene_expression (overexpression) of MIB1
10) Confidence 0.28 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.66 Pain Relevance 0
Archival paraffin sections were stained with hematoxylin–eosin (HE) and the monoclonal antibody MIB-1 (DakoCytomation, Glostrup, Denmark).
Gene_expression (stained) of MIB-1
11) Confidence 0.23 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 0.63 Pain Relevance 0.07
Immunochemistry also showed that the crescent component expressed less cytokeratin, vimentin and CD56, and more MIB-1 than the round component.
Gene_expression (expressed) of MIB-1 in crescent
12) Confidence 0.22 Published 2004 Journal World J Surg Oncol Section Body Doc Link PMC514615 Disease Relevance 0.66 Pain Relevance 0
There was strong bcl-2 overexpression, expression of MIB1, and p53 in >50% of nuclei, focally positive staining for prostate specific antigen and prostatic acid phosphatase and negative androgen receptor staining.
Gene_expression (expression) of MIB1
13) Confidence 0.18 Published 2006 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16723845 Disease Relevance 0.84 Pain Relevance 0.08
The proliferative index Ki-67 (MIB-1, 1:50, DAKO) was in a value range of 10–20% and p53 oncoprotein (DO-7, 1:20, DAKO) was weakly expressed in a few cells.
Gene_expression (expressed) of MIB-1
14) Confidence 0.18 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2630932 Disease Relevance 0.45 Pain Relevance 0.04
In a recently reported study, Ki-67 (MIB-1) expression was assessed in areas of low, medium, and high mammographic density in benign breast tissue obtained from reduction mammoplasties.
Gene_expression (expression) of MIB-1
15) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.50 Pain Relevance 0.04
Immunohistochemical studies, especially those focusing on CD31 (an endothelial marker), CD34 (expressed by blood vascular endothelial cells), D2-40 and LYVE-1 (lymphatic endothalial cells), markers of vascular proliferation such as the MIB1 proliferative index and VEGF expression within the lesions, would appear to be more useful for subdividing, or on the contrary uniting, these pathological entities.
Gene_expression (expression) of MIB1 in endothelial cells
16) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2830950 Disease Relevance 0.38 Pain Relevance 0
The proliferative activity measured by Ki-67 (as the antibody MIB-1) and p53 expression revealed a positive reaction in one adenoma with parasellar extension.
Gene_expression (expression) of MIB-1 associated with adenoma
17) Confidence 0.08 Published 1998 Journal Neurosurgery Section Abstract Doc Link 9574638 Disease Relevance 1.30 Pain Relevance 0.06
MiB1 was highly expressed indicating a high proliferative rate (up to 90%) in all cases.
Gene_expression (expressed) of MiB1
18) Confidence 0.07 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.69 Pain Relevance 0
MiB1 was expressed in 30% of the cells.
Gene_expression (expressed) of MiB1
19) Confidence 0.07 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.63 Pain Relevance 0
Aside from current Gleason grading and the number or percentage of cores involved with cancer, no molecular biomarker is approved for clinical use. p27, p53, bcl-2, Ki-67 (MIB-1), and the assessment of neovascularity hold promise, but prospective multicenter studies are needed.
Gene_expression (promise) of MIB-1 associated with cancer
20) Confidence 0.05 Published 2001 Journal Urol. Clin. North Am. Section Abstract Doc Link 11590806 Disease Relevance 0.39 Pain Relevance 0.12

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