INT671

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2011
Negated 8
Speculated 7
Reported most in Abstract
Documents 221
Total Number 229
Disease Relevance 164.50
Pain Relevance 47.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CeA 19
plasma 4
visceral 4
paw 4
T-cell 4
Cea (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 1311 100.00 Very High Very High Very High
gABA 60 100.00 Very High Very High Very High
GABAergic 40 100.00 Very High Very High Very High
opioid receptor 30 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
Nucleus accumbens 9 100.00 Very High Very High Very High
Regional anesthesia 45 99.96 Very High Very High Very High
anesthesia 68 99.92 Very High Very High Very High
addiction 17 99.92 Very High Very High Very High
Pain 370 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2008 100.00 Very High Very High Very High
Metastasis 524 100.00 Very High Very High Very High
Carcinoma 185 100.00 Very High Very High Very High
Epidural Abscess 20 100.00 Very High Very High Very High
Disease 454 99.98 Very High Very High Very High
Pancreatic Cancer 313 99.98 Very High Very High Very High
Pancreatitis 76 99.92 Very High Very High Very High
Subdural Empyema 20 99.90 Very High Very High Very High
Recurrence 156 99.88 Very High Very High Very High
Hyponatremia 1 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirty-six patients underwent abdominal exploration due to elevated carcinoembryonic antigen (CEA) levels after a curative resection for carcinoma of the colon and rectum.
Positive_regulation (elevated) of CEA in rectum associated with carcinoma
1) Confidence 0.69 Published 1986 Journal Surg Gynecol Obstet Section Abstract Doc Link 3704903 Disease Relevance 0.23 Pain Relevance 0
In group 2, 13 other asymptomatic patients underwent exploration because of elevated CEA levels in combination with other findings.
Positive_regulation (elevated) of CEA
2) Confidence 0.69 Published 1986 Journal Surg Gynecol Obstet Section Abstract Doc Link 3704903 Disease Relevance 0.50 Pain Relevance 0
A patient with a transient elevation of the serum carcinoembryonic antigen (CEA) associated with a benign disease was reported.
Positive_regulation (elevation) of CEA associated with disease
3) Confidence 0.69 Published 1991 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 1885126 Disease Relevance 0.83 Pain Relevance 0.08
Although a small number of case reports noted elevated carcinoembryonic antigen (CEA) in patients with primary central nervous system (CNS) neoplasms, there is no report of Ewing's sarcoma/peripheral primitive neuroectodermal tumor (PNET) with elevated serum levels of CEA.
Positive_regulation (elevated) of CEA in central nervous system associated with sarcoma, cancer, primitive neuroectodermal tumors and central nervous system
4) Confidence 0.69 Published 2001 Journal J. Neurooncol. Section Abstract Doc Link 11508817 Disease Relevance 0.86 Pain Relevance 0.17
In 53 p.c. of 175 patients with bronchial carcinoma the carcinoembryonic antigen (CEA) was elevated at the time of diagnosis.
Positive_regulation (elevated) of CEA associated with bronchogenic carcinoma
5) Confidence 0.69 Published 1978 Journal Thoraxchir Vask Chir Section Abstract Doc Link 77567 Disease Relevance 0.62 Pain Relevance 0.07
Laboratory tests showed anemia, hyponatremia, and increased carcinoembryonic antigen (CEA).
Positive_regulation (increased) of CEA associated with hyponatremia and anaemia
6) Confidence 0.69 Published 1999 Journal Praxis Section Abstract Doc Link 10522460 Disease Relevance 1.43 Pain Relevance 0.27
[A case of lumbar intradural and epidural abscesses presenting with elevated serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9)].
Positive_regulation (elevated) of CEA associated with epidural and abscess
7) Confidence 0.69 Published 2003 Journal No To Shinkei Section Title Doc Link 12833889 Disease Relevance 0.62 Pain Relevance 0.19
In 14 of 41 examinations, an increased FDG uptake was associated with a normal CEA value, and in only two cases were normal FDG uptake values and increased CEA levels found, suggesting that PET is more sensitive than the measurements of CEA plasma levels for tumor recurrence.
Positive_regulation (increased) of CEA in plasma associated with cancer and recurrence
8) Confidence 0.69 Published 1991 Journal J. Nucl. Med. Section Abstract Doc Link 1714497 Disease Relevance 0.77 Pain Relevance 0.17
We demonstrate that unilateral pharmacological activation of mGluR5 in the CeA produces distinct behavioral responses depending on whether the right or left amygdala is injected.
Positive_regulation (activation) of CeA in amygdala associated with amygdala
9) Confidence 0.68 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 0.96 Pain Relevance 0.85
Moreover, we demonstrate that phosphorylation of extracellular-signal regulated kinase 1/2 (ERK1/2) is downstream of mGluR5 activation in the CeA and is necessary for the full expression of peripheral inflammation-induced behavioral sensitization.
Positive_regulation (activation) of CeA in CeA associated with inflammation and amygdala
10) Confidence 0.68 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 0.98 Pain Relevance 0.78
Although a small number of case reports noted elevated carcinoembryonic antigen (CEA) in patients with primary central nervous system (CNS) neoplasms, there is no report of Ewing's sarcoma/peripheral primitive neuroectodermal tumor (PNET) with elevated serum levels of CEA.
Positive_regulation (elevated) of CEA in central nervous system associated with sarcoma, cancer, primitive neuroectodermal tumors and central nervous system
11) Confidence 0.60 Published 2001 Journal J. Neurooncol. Section Abstract Doc Link 11508817 Disease Relevance 1.14 Pain Relevance 0.19
This is the first reported case of a primary Ewing's sarcoma/peripheral PNET at the vertex of the skull with elevated serum CEA.
Positive_regulation (elevated) of serum CEA in skull associated with sarcoma and primitive neuroectodermal tumors
12) Confidence 0.60 Published 2001 Journal J. Neurooncol. Section Abstract Doc Link 11508817 Disease Relevance 1.30 Pain Relevance 0.13
These results suggest that modulation of pain by ERK activation in the CeA might be functionally lateralized to the right hemisphere.
Positive_regulation (activation) of CeA in CeA associated with pain and amygdala
13) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 1.30 Pain Relevance 0.96
Biochemical experiments showed that ERK is activated in the CeA during persistent inflammation.
Positive_regulation (activated) of CeA in CeA associated with inflammation and amygdala
14) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 1.03 Pain Relevance 0.86
The infused volume and doses of U0126 and U0124 were selected based on our previous biochemical experiments that showed that inhibition of ERK activation by U0126 under these conditions is restricted to the CeA and that 1.5 nmoles of U0126 is the lowest dose that significantly inhibits formalin-induced ERK activation in the CeA [4].


Positive_regulation (activation) of CeA associated with amygdala
15) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 0.15 Pain Relevance 0.16
In the present study, we tested whether ERK activation in the right CeA modulates pain independently of the side of peripheral inflammation by injecting formalin into the left hind-paw and then infusing U0126, U0124 or vehicle into the right CeA.
Spec (whether) Positive_regulation (activation) of CeA in paw associated with pain, inflammation and amygdala
16) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 0.52 Pain Relevance 0.55
We report a case which was remarkable for (1) diffuse, infiltrating growth which suggested chronic pancreatitis at laparotomy, and (2) an associated very high circulating carcinoembryonic antigen (CEA) level of 6400 ng/ml.
Positive_regulation (circulating) of CEA associated with chronic pancreatitis
17) Confidence 0.50 Published 1984 Journal Dig. Dis. Sci. Section Abstract Doc Link 6327210 Disease Relevance 0.52 Pain Relevance 0.10
During an 18-month period, a prospective study comparing the findings at computed tomography (CT) and magnetic resonance (MR) imaging was conducted on 35 patients who satisfied the following criteria: prior surgery for rectal cancer (11 curative resections, 24 rectal amputations), perineal pain and/or elevated carcinoembryonic antigen (CEA) level, and a soft-tissue mass in the presacral fossa demonstrated at CT.
Positive_regulation (elevated) of CEA in fossa associated with pain, reprotox - general 3, rectal cancer and imagery
18) Confidence 0.50 Published 1988 Journal Radiology Section Abstract Doc Link 3393651 Disease Relevance 0.77 Pain Relevance 0.38
High preoperative serum carcinoembryonic antigen (CEA) levels have been well investigated and found to be associated with poor prognosis in patients with colorectal cancer (CRC).
Spec (investigated) Positive_regulation (preoperative) of CEA associated with colon cancer
19) Confidence 0.50 Published 2006 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 17116621 Disease Relevance 0.38 Pain Relevance 0
CONCLUSION: Wake-up test can be used to directly assess the neurological status in patients undergoing CEA to determine whether shunting is required.
Positive_regulation (undergoing) of CEA
20) Confidence 0.50 Published 2010 Journal Vasc Endovascular Surg Section Body Doc Link 20150229 Disease Relevance 0 Pain Relevance 0

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