INT67133

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 18
Disease Relevance 18.57
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gusb) endoplasmic reticulum (Gusb) carbohydrate metabolic process (Gusb)
lysosome (Gusb)
Anatomy Link Frequency
thyroid 1
brain 1
gut 1
central nervous system 1
Gusb (Mus musculus)
Pain Link Frequency Relevance Heat
depression 448 100.00 Very High Very High Very High
Central nervous system 79 98.08 Very High Very High Very High
Fibrositis 25 97.76 Very High Very High Very High
Pain 53 86.56 High High
Inflammation 81 86.40 High High
Multiple sclerosis 46 83.24 Quite High
backache 1 74.00 Quite High
Spinal cord 12 62.08 Quite High
withdrawal 20 26.36 Quite Low
Inflammatory response 12 25.00 Low Low
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 486 100.00 Very High Very High Very High
Depression 464 100.00 Very High Very High Very High
Syndrome 393 100.00 Very High Very High Very High
Autoimmune Disease 335 100.00 Very High Very High Very High
Cold Sores 1103 99.80 Very High Very High Very High
Thyroid Disease 35 99.48 Very High Very High Very High
Lysosome Storage Disease 24 99.32 Very High Very High Very High
Phobia 165 98.88 Very High Very High Very High
Sleep Disorders 26 97.76 Very High Very High Very High
Convulsion 222 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Towards this end, a dose of 1.86 mg/kg, i.p. was chosen because it increases both mesenteric and systemic blood melatonin levels (Fig. 1a) without drastically decreasing levels of gut AA-NAT mRNA expression (Fig. 1c).
Gene_expression (expression) of gut in gut
1) Confidence 0.75 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.61 Pain Relevance 0.15
In previous studies, we have shown that a herpesvirus vector can transfer a therapeutic cellular gene (beta-glucuronidase) from peripheral sites of inoculation into the central nervous system in mice with a model neurodegenerative disease caused by a deficiency of this enzyme (mucopolysaccharidosis type VII, Sly disease).
Gene_expression (transfer) of beta-glucuronidase in central nervous system associated with mucopolysaccharidosis vii, mucopolysaccharidoses, central nervous system and neurodegenerative disease
2) Confidence 0.44 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8972424 Disease Relevance 0.47 Pain Relevance 0.05
We studied whether memory specificity is related to major depression, ASD, and specific assault-related phobia at 2 weeks postassault.
Gene_expression (depression) of ASD associated with phobia, post-traumatic stress disorder and depression
3) Confidence 0.35 Published 2008 Journal J Consult Clin Psychol Section Body Doc Link PMC2672050 Disease Relevance 1.46 Pain Relevance 0.20
Nevertheless, our findings show that OGM was specific to depression and ASD, whereas participants with phobia did not differ from participants without phobia in autobiographical memory retrieval.
Gene_expression (depression) of ASD associated with phobia, post-traumatic stress disorder and depression
4) Confidence 0.35 Published 2008 Journal J Consult Clin Psychol Section Body Doc Link PMC2672050 Disease Relevance 1.41 Pain Relevance 0.12
There was also a significant interaction between valence and ASD, F(1, 195) = 4.09, p = .045, ?
Gene_expression (valence) of ASD associated with post-traumatic stress disorder
5) Confidence 0.35 Published 2008 Journal J Consult Clin Psychol Section Body Doc Link PMC2672050 Disease Relevance 0.75 Pain Relevance 0.09
= .97 for ASD, ?
Gene_expression (for) of ASD associated with post-traumatic stress disorder
6) Confidence 0.35 Published 2008 Journal J Consult Clin Psychol Section Body Doc Link PMC2672050 Disease Relevance 1.24 Pain Relevance 0.09
The ASD and PTSD severity were associated (r = .54), but ASD status was not a sensitive predictor of later PTSD.
Gene_expression (status) of ASD associated with post-traumatic stress disorder
7) Confidence 0.34 Published 2009 Journal J Trauma Stress Section Abstract Doc Link 19637323 Disease Relevance 1.88 Pain Relevance 0.09
Autoimmune disease, ASD, and other neurodevelopmental problems
Gene_expression (disease) of ASD associated with autoimmune disease
8) Confidence 0.32 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.27 Pain Relevance 0.04
Of the 32 mothers with children that had FXS and ASD, autoimmune thyroid disease was present in 22 (67.6%), fibromyalgia in 8 (25.0%), and Raynaud’s phenomenon in 4 (12.5%).
Gene_expression (had) of ASD in thyroid associated with syndrome, thyroid disease and fibrositis
9) Confidence 0.32 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.48 Pain Relevance 0.05
In conclusion, autoimmune disease in carrier mothers was not associated with the presence of ASD in their children.
Gene_expression (presence) of ASD associated with autoimmune disease
10) Confidence 0.32 Published 2010 Journal Hum Genet Section Abstract Doc Link PMC2955238 Disease Relevance 1.77 Pain Relevance 0
In conclusion, autoimmune disease in mothers was not significantly associated with the presence of ASD in their children with FXS.
Gene_expression (presence) of ASD associated with autoimmune disease and syndrome
11) Confidence 0.32 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.46 Pain Relevance 0.07
Fisher’s exact test for 2 × 2 contingency table analyses were used to assess the association between autoimmune status in the mothers of children with FXS and the diagnosis of ASD.
Gene_expression (diagnosis) of ASD associated with syndrome
12) Confidence 0.32 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 0.72 Pain Relevance 0
The authors have shown that this neuroattenuated vector was able to establish latency and to express GUSB at a distance from the site of injection and the correction of the lysosomal storage was demonstrated in several brain regions.
Gene_expression (express) of GUSB in brain associated with lysosome storage disease
13) Confidence 0.28 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.13 Pain Relevance 0.12
The investigators have demonstrated the capacity of HSV1716 virus expressing GUSB driven by the latency-associated transcript promoter (HSV-1716-LAT-GUSB virus) to correct the lysosomal storage in the adult MPS VII mouse model following intracranial injection.
Gene_expression (virus) of GUSB associated with cold sores and lysosome storage disease
14) Confidence 0.24 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.99 Pain Relevance 0.11
The investigators have demonstrated the capacity of HSV1716 virus expressing GUSB driven by the latency-associated transcript promoter (HSV-1716-LAT-GUSB virus) to correct the lysosomal storage in the adult MPS VII mouse model following intracranial injection.
Gene_expression (expressing) of GUSB associated with cold sores and lysosome storage disease
15) Confidence 0.21 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.95 Pain Relevance 0.11
A fraction containing most exclusively the sulfated polysaccharide known as ulvan-induced expression of a GUS gene placed under the control of a lipoxygenase gene promoter.
Gene_expression (expression) of GUS
16) Confidence 0.19 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2860583 Disease Relevance 0.09 Pain Relevance 0
Arrhythmias after ASD repair
Gene_expression (repair) of ASD
17) Confidence 0.06 Published 2008 Journal J Interv Card Electrophysiol Section Body Doc Link PMC2493534 Disease Relevance 0.81 Pain Relevance 0
The results were inconsistent: Even 16-20 years after fusion no significant ASD was found in a majority of cases on plain x-rays [1] if compared to a non-operated control group.
Neg (no) Gene_expression (found) of ASD
18) Confidence 0.03 Published 2003 Journal German Medical Science : GMS e-journal Section Body Doc Link PMC2703223 Disease Relevance 0.07 Pain Relevance 0.07

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