INT67135

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Context Info
Confidence 0.10
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.20
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gc) transport (Gc) extracellular space (Gc)
extracellular region (Gc)
Anatomy Link Frequency
muscle cell 1
muscle 1
Gc (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 246 98.72 Very High Very High Very High
Central nervous system 3 66.04 Quite High
Inflammatory response 3 62.24 Quite High
fibrosis 3 55.08 Quite High
Demyelination 6 42.08 Quite Low
anesthesia 3 25.00 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 1 100.00 Very High Very High Very High
Muscle Weakness 6 99.48 Very High Very High Very High
Cold Sores 2 99.32 Very High Very High Very High
Demyelinating Disease 252 98.72 Very High Very High Very High
Infection 1 98.08 Very High Very High Very High
Neurological Disease 4 86.64 High High
Sprains And Strains 2 86.04 High High
Disease 42 77.24 Quite High
Mucopolysaccharidosis Vii 1 71.24 Quite High
Mucopolysaccharidoses 1 70.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More than 99% of 25-hydroxyvitamin D, the principle circulating metabolite of vitamin D is bound to proteins, of which approximately 90% is bound to vitamin D-binding protein [33], [34].
vitamin D-binding protein Binding (bound) of
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.17 Pain Relevance 0.47
Aberration of normal homeostasis of Vitamin D, of which approximately 90% is bound to vitamin D-binding protein, has been widely implicated in MScl for some years now.
vitamin D-binding protein Binding (bound) of associated with multiple sclerosis
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2929207 Disease Relevance 0.75 Pain Relevance 0.37
The pathogenic effect of the vector virus in the mutants could be blocked by passive immunization with human gamma-globulin containing anti-HSV-1 antibodies on the day of infection but not when given at the peak of viral replication (day 4).
gamma-globulin Binding (immunization) of associated with cold sores, immunization and infection
3) Confidence 0.04 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8972424 Disease Relevance 0.89 Pain Relevance 0.06
Vitamin D and calcium supplementation accounted for a 49% reduction in the risk of a fall (P?
Vitamin D Binding (accounted) of
4) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.12 Pain Relevance 0.03
Binding of vitamin D to its receptor results in the activation of several signaling pathways, including calcium uptake into the muscle cell, phosphate transport across the cell membrane, phospholipid metabolism, and muscle cell proliferation and differentiation [9••].
vitamin D Binding (Binding) of in muscle cell
5) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.06 Pain Relevance 0
During the past 10 to 20 years, many case reports have documented that in both young and old individuals, prolonged vitamin D deficiency can be associated with severe muscle weakness and disability and has been found to improve within several weeks of vitamin D supplementation [5, 6].
vitamin D Binding (associated) of in muscle associated with muscle weakness
6) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.22 Pain Relevance 0

General Comments

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