INT67137

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Context Info
Confidence 0.26
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 9.67
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
blood 1
erythrocyte 1
brain 1
syncytiotrophoblast 1
Mpeg1 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 64 99.44 Very High Very High Very High
methadone 156 99.36 Very High Very High Very High
Inflammatory response 29 97.92 Very High Very High Very High
Inflammation 119 96.88 Very High Very High Very High
cytokine 35 90.72 High High
Inflammatory marker 7 90.44 High High
Central nervous system 1 78.68 Quite High
addiction 4 59.20 Quite High
opiate 8 58.80 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Malaria 490 99.62 Very High Very High Very High
Infection 169 99.60 Very High Very High Very High
Acute Disease 7 98.76 Very High Very High Very High
Sprains And Strains 2 98.68 Very High Very High Very High
Fever 77 98.32 Very High Very High Very High
Cold Sores 2 98.32 Very High Very High Very High
INFLAMMATION 155 97.72 Very High Very High Very High
Disease 72 97.12 Very High Very High Very High
Ovarian Cancer 35 95.20 Very High Very High Very High
Communicable Diseases 7 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore attempted to increase the number of corrected cells in the MPS VII brain by increasing the inoculating dose of the vector.
Positive_regulation (increase) of MPS VII in brain
1) Confidence 0.26 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8972424 Disease Relevance 0.76 Pain Relevance 0.04
The results showed that platelet (PMPs), erythrocyte (EMPs) and leukocyte (LMPs) derived-MPs are significantly increased in plasma from P. vivax patients as compared to healthy donors.
Positive_regulation (increased) of MPs in erythrocyte
2) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2998527 Disease Relevance 1.18 Pain Relevance 0.11
Because acute vivax malaria has been related to pro-inflammatory responses, the main hypothesis investigated in this study was that Plasmodium vivax infection is associated with elevated levels of circulating MPs, which may play a role during acute disease in non-immune patients.


Positive_regulation (elevated) of MPs associated with malaria, inflammatory response, acute disease and infection
3) Confidence 0.04 Published 2010 Journal Malar J Section Abstract Doc Link PMC2998527 Disease Relevance 1.49 Pain Relevance 0.09
It is shown here that the plasma levels of platelet, erythrocyte and leukocyte-derived MPs are increased during acute uncomplicated vivax malaria.
Positive_regulation (increased) of MPs in plasma associated with malaria
4) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2998527 Disease Relevance 0.85 Pain Relevance 0.05
The frequencies of plasma circulating MPs were markedly increased in P. vivax patients, as compared to healthy age-matched malaria-unexposed controls.
Positive_regulation (increased) of MPs in plasma associated with malaria
5) Confidence 0.03 Published 2010 Journal Malar J Section Abstract Doc Link PMC2998527 Disease Relevance 1.70 Pain Relevance 0.06
The main hypothesis to be investigated here is that P. vivax infection is associated with elevated levels of circulating MPs of different cellular origins, and those MPs play a role in P. vivax induced inflammation.
Positive_regulation (elevated) of MPs associated with inflammation and infection
6) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2998527 Disease Relevance 1.41 Pain Relevance 0.24
This study provides the first evidence that microparticles (MPs) from leukocytes, platelets, and erythrocytes are significantly increased in plasma from acute P. vivax malaria patients.
Positive_regulation (increased) of MPs in plasma associated with malaria
7) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2998527 Disease Relevance 0.70 Pain Relevance 0.07
Although platelets, erythrocytes and leukocytes were the main cellular sources of MPs during vivax malaria, platelet derived-MPs (PMPs) increased in a linear fashion with the presence of fever at the time of blood collection (?
Positive_regulation (increased) of MPs in blood associated with malaria and fever
8) Confidence 0.03 Published 2010 Journal Malar J Section Abstract Doc Link PMC2998527 Disease Relevance 1.52 Pain Relevance 0.05
The accumulation of MPs increased after perfusion with methadone/cocaine 128 ± 8% of the control (P = 0.03).
Positive_regulation (accumulation) of MPs associated with methadone and cocaine
9) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2703629 Disease Relevance 0 Pain Relevance 0.81
Microparticles (MPs) released from syncytiotrophoblast into maternal circuit increased by 30% after cocaine or heroin (P < 0.05) and the expression of P-glycoprotein in the tissue increased by ?
Positive_regulation (increased) of MPs in syncytiotrophoblast associated with cocaine
10) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2703629 Disease Relevance 0.06 Pain Relevance 1.20

General Comments

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