INT67138

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Context Info
Confidence 0.31
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 17.11
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gc) transport (Gc) extracellular space (Gc)
extracellular region (Gc)
Anatomy Link Frequency
Clara cell 2
thyroid 1
forearm 1
hip 1
pigmentation 1
Gc (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 616 100.00 Very High Very High Very High
fibrosis 82 99.60 Very High Very High Very High
corticosteroid 84 94.20 High High
abdominal pain 4 89.16 High High
Pain 12 85.44 High High
Central nervous system 7 65.08 Quite High
Inflammatory response 6 63.12 Quite High
Demyelination 15 38.16 Quite Low
anesthesia 6 25.00 Low Low
withdrawal 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 631 100.00 Very High Very High Very High
Sunburn 10 99.84 Very High Very High Very High
Cold Sores 2 99.76 Very High Very High Very High
Immunization 1 99.76 Very High Very High Very High
Cystic Fibrosis 73 99.60 Very High Very High Very High
Disease 304 99.26 Very High Very High Very High
Systemic Lupus Erythematosus 46 98.86 Very High Very High Very High
Infection 38 98.52 Very High Very High Very High
Serum Sickness 2 97.92 Very High Very High Very High
Neurological Disease 10 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2 microglobulins, retinol-binding protein (RBP), Clara cell protein, and vitamin D binding protein, is found in approximately 99% of affected males.
Gene_expression (retinol-binding protein) of vitamin D binding protein in Clara cell
1) Confidence 0.31 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2964617 Disease Relevance 2.05 Pain Relevance 0.17
2 microglobulins, retinol-binding protein (RBP), Clara cell protein, and vitamin D binding protein, is found in approximately 99% of affected males.
Gene_expression (found) of vitamin D binding protein in Clara cell
2) Confidence 0.31 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2964617 Disease Relevance 2.01 Pain Relevance 0.17
While our results do not indicate a differential abundance difference between the MScl subtypes and the controls, the two disease types did vary significantly in CSF levels of vitamin D-binding protein, with RR MScl showing a higher abundance.
Gene_expression (levels) of vitamin D-binding protein associated with multiple sclerosis and disease
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.03 Pain Relevance 0.38
Another interesting differentially abundant protein is vitamin D-binding protein, which was not detected by mass spectrometry in the PP MScl samples but was detected in the RR MScl samples.
Gene_expression (detected) of vitamin D-binding protein associated with multiple sclerosis
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 2.02 Pain Relevance 0.98
Another interesting differentially abundant protein is vitamin D-binding protein, which was not detected by mass spectrometry in the PP MScl samples but was detected in the RR MScl samples.
Neg (not) Gene_expression (detected) of vitamin D-binding protein associated with multiple sclerosis
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.98 Pain Relevance 0.96
Recently, a CSF proteomics study showed that serum levels of vitamin D-binding protein were decreased significantly in RR MScl patients compared to other neurological disorders[35].
Gene_expression (levels) of vitamin D-binding protein associated with multiple sclerosis and neurological disease
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.19 Pain Relevance 0.45
Vitamin D-binding protein was only detected in the RR MScl samples.
Gene_expression (detected) of Vitamin D-binding protein associated with multiple sclerosis
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2929207 Disease Relevance 1.27 Pain Relevance 0.57
In contrast to other vitamins, dietary intake is usually a minor source of vitamin D and provides only about 100 IU/d.
Gene_expression (source) of vitamin D
8) Confidence 0.08 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.15 Pain Relevance 0
The pathogenic effect of the vector virus in the mutants could be blocked by passive immunization with human gamma-globulin containing anti-HSV-1 antibodies on the day of infection but not when given at the peak of viral replication (day 4).
Gene_expression (containing) of gamma-globulin associated with cold sores, immunization and infection
9) Confidence 0.07 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8972424 Disease Relevance 0.89 Pain Relevance 0.06
The incidence of fracture of the hip, wrist, forearm, or vertebrae was 4.5% in volunteers assigned to receive vitamin D and 6.5% in those given placebo (P?
Gene_expression (receive) of vitamin D in forearm
10) Confidence 0.07 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.58 Pain Relevance 0
Maintenance of calcium levels in the body is organized in a balanced system, with vitamin D acting to produce enough gastrointestinal absorption of calcium to satisfy calcium demand and bone turnover.
Gene_expression (produce) of vitamin D in body
11) Confidence 0.07 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.07 Pain Relevance 0
Decreased storage of both produced and consumed vitamin D may also be due to decreased levels of vitamin D binding protein (DBP) in CF patients, a phenomenon known to exist for 3 decades [26].
Gene_expression (levels) of vitamin D binding protein associated with fibrosis
12) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817861 Disease Relevance 0.61 Pain Relevance 0.26
A high percentage of systemic lupus erythematosus patients are reported to have insufficient or deficient levels of vitamin D.
Gene_expression (levels) of vitamin D associated with systemic lupus erythematosus
13) Confidence 0.06 Published 2010 Journal Curr Rheumatol Rep Section Abstract Doc Link PMC2902729 Disease Relevance 0.17 Pain Relevance 0
The major source of vitamin D is sun exposure; thus, active vitamin D in the body can be affected by the season and the duration of direct exposure to sunlight and can be inhibited by sunscreen use and increased skin pigmentation.
Gene_expression (source) of vitamin D in pigmentation associated with sunburn
14) Confidence 0.06 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.17 Pain Relevance 0
No exogenous nuclear ligand is needed because Hr is capable of repressing gene expression of unliganded Vitamin D [15], [38] and thyroid receptors [39].
Gene_expression (expression) of Vitamin D in thyroid
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.38 Pain Relevance 0
The incidence of fracture of the hip, wrist, forearm, or vertebrae was 4.5% in volunteers assigned to receive vitamin D and 6.5% in those given placebo (P?
Gene_expression (receive) of vitamin D in hip
16) Confidence 0.02 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.58 Pain Relevance 0
The incidence of fracture of the hip, wrist, forearm, or vertebrae was 4.5% in volunteers assigned to receive vitamin D and 6.5% in those given placebo (P?
Gene_expression (receive) of vitamin D in wrist
17) Confidence 0.02 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.58 Pain Relevance 0
Induction with these early antilymphocyte globulins was associated with fewer rejection episodes; but the production of antilymphocyte globulin was often a local, nonstandardized affair, and the results with these drugs, sometimes very good, were not reproducible between and within transplant centers.
Gene_expression (production) of antilymphocyte globulin
18) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721359 Disease Relevance 0.24 Pain Relevance 0.04
In 1967 equine antilymphocyte globulin was cautiously introduced as an adjuvant immunosuppressant, despite fears of serum sickness and anaphylactic reactions (Brent 1997).
Gene_expression (introduced) of antilymphocyte globulin associated with anaphylaxis and serum sickness
19) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721359 Disease Relevance 0.32 Pain Relevance 0.05
Women with silicone implants, however, had unexpectedly low serum globulin and immunoglobulin levels, with or without the subsequent development of CTD.
Gene_expression (levels) of serum globulin associated with disease
20) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212583 Disease Relevance 0.82 Pain Relevance 0

General Comments

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