INT67140

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.54
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CER 1
Mod2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 7 100.00 Very High Very High Very High
antinociception 2 93.60 High High
metalloproteinase 1 63.20 Quite High
antagonist 4 54.72 Quite High
agonist 2 38.32 Quite Low
vincristine 1 30.40 Quite Low
Eae 1 25.00 Low Low
tolerance 20 5.00 Very Low Very Low Very Low
cytokine 19 5.00 Very Low Very Low Very Low
Inflammation 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 170 100.00 Very High Very High Very High
Stress 59 100.00 Very High Very High Very High
Apoptosis 46 100.00 Very High Very High Very High
Breast Cancer 7 96.48 Very High Very High Very High
Solid Tumor 2 95.76 Very High Very High Very High
Anxiety Disorder 2 92.24 High High
Adenocarcinoma 26 88.08 High High
Peripheral Arterial Disease 3 80.32 Quite High
Pancreatic Cancer 1 79.28 Quite High
Leukemia 3 70.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuroactive steroidal modulation of immobilization-stress and possible involvement of GABA-A and mitochondrial diazepam binding inhibitor (DBI) receptors (MDR) has been investigated in mice.
Regulation (modulation) of MDR associated with stress and gaba
1) Confidence 0.41 Published 1996 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8972548 Disease Relevance 0.42 Pain Relevance 0.31
In this study, we have examined the delivery of combination PTX and CER to modulate the apoptotic threshold in tumor MDR by formulating both of these drugs in a single PLGA/PbAE (70:30 by weight) blend nanoparticles.
Spec (examined) Regulation (modulate) of MDR in CER associated with cancer and apoptosis
2) Confidence 0.10 Published 2008 Journal Molecular Pharmaceutics Section Body Doc Link PMC2646668 Disease Relevance 1.23 Pain Relevance 0
Role of redox-sensitive signaling proteins and MDR
Regulation (Role) of MDR
3) Confidence 0.05 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.89 Pain Relevance 0.03

General Comments

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