INT67144

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Context Info
Confidence 0.76
First Reported 1996
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 17
Total Number 21
Disease Relevance 8.94
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) plasma membrane (Cd44) nucleus (Cd44)
protein complex (Cd44)
Anatomy Link Frequency
monocytes 4
retina 1
spinal cord 1
joints 1
granulocytes 1
Cd44 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 58 99.92 Very High Very High Very High
Spinal cord 12 99.68 Very High Very High Very High
Inflammation 177 99.04 Very High Very High Very High
Chronic pancreatitis 11 98.72 Very High Very High Very High
Neuritis 16 98.68 Very High Very High Very High
chemokine 10 92.48 High High
Inflammatory response 25 89.16 High High
Sciatic nerve 2 85.40 High High
Snapping jaw 7 83.04 Quite High
Central nervous system 2 77.20 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 62 99.92 Very High Very High Very High
Adenocarcinoma 24 99.84 Very High Very High Very High
Diabetes Mellitus 58 99.72 Very High Very High Very High
INFLAMMATION 214 99.04 Very High Very High Very High
Pancreatitis 12 98.72 Very High Very High Very High
Experimental Autoimmune Neuritis 16 98.68 Very High Very High Very High
Hyperplasia 10 97.00 Very High Very High Very High
Metastasis 13 95.32 Very High Very High Very High
Infection 28 94.36 High High
Injury 22 81.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study has investigated standard CD44 (CD44s) and CD44v6 expression immunohistochemically in 6 samples of normal pancreatic tissue, 4 of tissue affected by chronic pancreatitis, and 24 of tissue from metastasizing and nonmetastasizing pancreatic adenocarcinomas.
Spec (investigated) Gene_expression (expression) of CD44v6 associated with adenocarcinoma and chronic pancreatitis
1) Confidence 0.76 Published 1996 Journal Virchows Arch. Section Abstract Doc Link 8972753 Disease Relevance 0.78 Pain Relevance 0.16
Differential expression of CD44v6 in adenocarcinoma of the pancreas: an immunohistochemical study.
Gene_expression (expression) of CD44v6 in pancreas associated with adenocarcinoma
2) Confidence 0.76 Published 1996 Journal Virchows Arch. Section Title Doc Link 8972753 Disease Relevance 0.82 Pain Relevance 0.14
In contrast, CD44v6 was not detected in any of the normal tissue or chronic pancreatitis specimens, whereas 54% of pancreatic adenocarcinomas and 55% of metastases expressed this variant exon.
Neg (not) Gene_expression (detected) of CD44v6 associated with adenocarcinoma, chronic pancreatitis and metastasis
3) Confidence 0.76 Published 1996 Journal Virchows Arch. Section Abstract Doc Link 8972753 Disease Relevance 0.98 Pain Relevance 0.19
This study has investigated standard CD44 (CD44s) and CD44v6 expression immunohistochemically in 6 samples of normal pancreatic tissue, 4 of tissue affected by chronic pancreatitis, and 24 of tissue from metastasizing and nonmetastasizing pancreatic adenocarcinomas.
Spec (investigated) Gene_expression (expression) of CD44 associated with adenocarcinoma and chronic pancreatitis
4) Confidence 0.76 Published 1996 Journal Virchows Arch. Section Abstract Doc Link 8972753 Disease Relevance 0.79 Pain Relevance 0.16
Expression of CD44, a receptor of OPN, was weak in normal spinal cord tissue and increased in the entire spinal cord parenchyma in rats with EAN, as well as in inflammatory cells.
Gene_expression (Expression) of CD44 in spinal cord associated with inflammation, neuritis and spinal cord
5) Confidence 0.71 Published 2004 Journal J. Vet. Sci. Section Abstract Doc Link 15613811 Disease Relevance 0.88 Pain Relevance 1.14
These findings suggest that inflammatory cells as well as reactive astrocytes are major sources of OPN and CD44 in the spinal cord of rats with EAN.
Gene_expression (sources) of CD44 in astrocytes associated with inflammation, neuritis and spinal cord
6) Confidence 0.71 Published 2004 Journal J. Vet. Sci. Section Abstract Doc Link 15613811 Disease Relevance 0.93 Pain Relevance 1.14
In addition, the expression of CD44, of the integrin component CD18, and of MHC class II was determined.
Spec (determined) Gene_expression (expression) of CD44
7) Confidence 0.69 Published 2002 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 12030436 Disease Relevance 0.33 Pain Relevance 0.29
This localization pattern of CD44 and HABP might be involved in the formation of the epithelial arrangement of the synovial lining layer.
Gene_expression (pattern) of CD44
8) Confidence 0.56 Published 2006 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 16673425 Disease Relevance 0.30 Pain Relevance 0.22
CD44 is a widely expressed glycoprotein that plays a direct role in leukocyte trafficking to the retina [34].
Gene_expression (expressed) of CD44 in retina
9) Confidence 0.43 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.82 Pain Relevance 0.30
Flow cytometry analysis showed that the positive incidence of CD29, CD44, and CD90 were 81.56%, 88.77%, and 98.43%, respectively, while the positive incidence of CD34, CD45, CD71, and CD133 were 0.10%, 0.17%, 10.02%, and 1.56%, respectively (Figure 1C).
Gene_expression (incidence) of CD44
10) Confidence 0.39 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905634 Disease Relevance 0 Pain Relevance 0
Cultivated MSCs were positive for CD29, CD44, and CD90, but negative for CD34, CD45, CD133, and CK12, with typical MSCs characteristics revealed by SEM.
Neg (negative) Gene_expression (negative) of CD44
11) Confidence 0.35 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2905634 Disease Relevance 0.16 Pain Relevance 0
CD44 and CD29 expressions were observed in 92% and 90%, respectively.
Gene_expression (expressions) of CD44
12) Confidence 0.30 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799983 Disease Relevance 0 Pain Relevance 0
No significant modification in the expression of CD44 or in the percentage of CD25+ cells was evidenced in circulating granulocytes and lymphocytes (not shown).
Gene_expression (expression) of CD44 in granulocytes
13) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.11 Pain Relevance 0
These latter cells also exhibited an enhanced potential of extravasation ability, as suggested by increased expression of CD44 on their cellular membrane [18], as well as characteristics of activated monocytes [19,20], as indicated by the higher percentage of CD25+ cells in circulating monocytes, compared to the untreated control rats.
Gene_expression (expression) of CD44 in monocytes
14) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.22 Pain Relevance 0.08
The expression of CD44 and the percentage of CD25+ cells in circulating monocytes from treated and untreated rats were evaluated by cytofluorimetric analysis.
Gene_expression (expression) of CD44 in monocytes
15) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.09 Pain Relevance 0
Evaluation of CD44 expression and CD25+ cells in circulating monocytes
Gene_expression (expression) of CD44 in monocytes
16) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.09 Pain Relevance 0
Cytofluorimetric analysis showed that at T15 EO treatment induced a significant increase of the expression of CD44, as well as the percentage of CD25+ cells in circulating monocytes compared to the untreated control rats, and this effect also persisted at T20, after 5 days from the end of EO administration (Fig. 6e, f).
Gene_expression (expression) of CD44 in monocytes
17) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0 Pain Relevance 0
In particular we evaluated the expression of CD44, the receptor for the extracellular matrix component hyaluronan that mediates the leukocyte/endothelial interactions leading to extravasation [18], and of CD25, a marker of circulating monocyte activation [19,20].
Gene_expression (expression) of CD44 in leukocyte
18) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0 Pain Relevance 0
CD44, CTGF or iNOS expression was increased in the synovial lining of OA joints compared with normal, but there was no significant modulation of this increase by either HA preparation.
Gene_expression (expression) of CD44 in joints
19) Confidence 0.18 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468886 Disease Relevance 0.53 Pain Relevance 0.21
CD44, a multivariate transmembrane glycoprotein known to be the principle cell surface receptor for HA [46], is present in the synovium [47] and SF [40] of OA patients and levels correlate with the degree of inflammation but not Kellgren grade [40].
Gene_expression (present) of CD44 in synovium associated with inflammation
20) Confidence 0.18 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 1.01 Pain Relevance 0.44

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