INT67146

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Context Info
Confidence 0.17
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 9.08
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skeletal muscle 4
hypothalamus 2
ovary 2
Hypism (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 4 99.54 Very High Very High Very High
Inflammation 114 97.64 Very High Very High Very High
Central nervous system 1 87.36 High High
Pain score 1 86.96 High High
melanocortin 1 receptor 11 82.36 Quite High
cytokine 39 78.52 Quite High
tolerance 1 77.16 Quite High
anesthesia 4 70.96 Quite High
chemokine 21 15.16 Low Low
Inflammatory marker 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 227 100.00 Very High Very High Very High
Targeted Disruption 189 100.00 Very High Very High Very High
Insulin Resistance 121 100.00 Very High Very High Very High
Hyperinsulinism 19 100.00 Very High Very High Very High
Hyperphagia 2 100.00 Very High Very High Very High
Diabetes Mellitus 45 99.92 Very High Very High Very High
Polycystic Ovary Syndrome 1 99.08 Very High Very High Very High
INFLAMMATION 126 97.64 Very High Very High Very High
Weight Loss 4 97.56 Very High Very High Very High
Hypertension 4 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the hyperinsulinemia, hyperphagia, and obesity in lethal yellow and viable yellow mice is caused primarily by agouti-induced antagonism of Mc4r in the hypothalamus, a center of autonomic regulatory control in the brain [35].
Positive_regulation (caused) of Gene_expression (obesity) of hyperinsulinemia in hypothalamus associated with hyperphagia, obesity and hyperinsulinism
1) Confidence 0.17 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.43 Pain Relevance 0.13
Two-week high fat feeding induced hyperinsulinemia and severe hepatic and skeletal muscle insulin resistance in WT but not 12/15LO KO mice. 12/15LO KO mice exhibited significantly greater insulin-stimulated skeletal muscle Akt phosphorylation after HFD, compared to WT mice, corresponding to their greater insulin sensitivity.
Positive_regulation (induced) of Gene_expression (resistance) of hyperinsulinemia in skeletal muscle associated with targeted disruption, hyperinsulinism and insulin resistance
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 2.04 Pain Relevance 0.27
Two-week high fat feeding induced hyperinsulinemia and severe hepatic and skeletal muscle insulin resistance in WT but not 12/15LO KO mice. 12/15LO KO mice exhibited significantly greater insulin-stimulated skeletal muscle Akt phosphorylation after HFD, compared to WT mice, corresponding to their greater insulin sensitivity.
Positive_regulation (stimulated) of Gene_expression (resistance) of hyperinsulinemia in skeletal muscle associated with targeted disruption, hyperinsulinism and insulin resistance
3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 2.15 Pain Relevance 0.27
HFD-fed 12/15LO KO mice did exhibit a similar fold increase in eWAT mass but not hyperinsulinemia, compared to HFD-fed WT mice (Table 1).
Positive_regulation (increase) of Gene_expression (mass) of hyperinsulinemia associated with targeted disruption and hyperinsulinism
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.52 Pain Relevance 0.06
These include increasing age, increasing body mass index (BMI), hyperinsulinemia, insulin resistance, type 2 diabetes, and polycystic ovary syndrome.
Positive_regulation (increasing) of Gene_expression (resistance) of hyperinsulinemia in ovary associated with diabetes mellitus, obesity, polycystic ovary syndrome, hyperinsulinism and insulin resistance
5) Confidence 0.06 Published 2002 Journal Am. J. Surg. Section Abstract Doc Link 12527345 Disease Relevance 1.21 Pain Relevance 0.09
Estrogen withdrawal in these animals also induces fasting and glucose-stimulated hyperinsulinemia, which are signs of worsening insulin resistance.
Positive_regulation (induces) of Gene_expression (resistance) of hyperinsulinemia associated with hyperinsulinism, insulin resistance and withdrawal
6) Confidence 0.03 Published 1996 Journal Am. J. Hypertens. Section Abstract Doc Link 8972891 Disease Relevance 0.74 Pain Relevance 0.27

General Comments

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