INT67169

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.94
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GOT2) mitochondrion (GOT2) small molecule metabolic process (GOT2)
biosynthetic process (GOT2) plasma membrane (GOT2) carbohydrate metabolic process (GOT2)
Anatomy Link Frequency
osteoclasts 1
GOT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 4 75.00 Quite High
Paracetamol 1 68.56 Quite High
Analgesic 1 67.76 Quite High
tolerance 1 58.08 Quite High
fibrosis 1 52.00 Quite High
cytokine 9 25.00 Low Low
Inflammation 6 10.92 Low Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 3 90.32 High High
Alcoholic Liver Cirrhosis 1 87.48 High High
Infection 32 80.76 Quite High
Immunodeficiency 2 80.12 Quite High
Toxicity 2 79.80 Quite High
Hypercalcemia 8 76.40 Quite High
Injury 1 75.00 Quite High
Hepatotoxicity 1 73.72 Quite High
Osteoporosis 15 66.60 Quite High
Fibrosis 1 52.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene expression profile of primary osteoclasts and osteoblasts has been evaluated ex vivo following tenofovir exposure.61,62 Specific downregulation of Gnas, Got2, and Snord32a was observed in osteoclasts.
Negative_regulation (downregulation) of Got2 in osteoclasts
1) Confidence 0.36 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946855 Disease Relevance 0.46 Pain Relevance 0
Gender differences are related, in part, to lower gastric ADH activity (with consequent reduction of first pass ethanol metabolism) in young women, decreased hepatic fatty acid binding protein and increased free-fatty acid levels as well as lesser omega-hydroxylation, all of which result in increased vulnerability to ethanol.
Negative_regulation (decreased) of fatty acid binding protein
2) Confidence 0.05 Published 1994 Journal Alcohol Alcohol Suppl Section Abstract Doc Link 8974351 Disease Relevance 0.48 Pain Relevance 0.25

General Comments

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