INT6717

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 45
Total Number 45
Disease Relevance 15.35
Pain Relevance 27.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
spinal 2
NG108-15 2
brain 2
bile 2
SK-N-SH 2
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 87 100.00 Very High Very High Very High
Pain 87 100.00 Very High Very High Very High
antagonist 38 100.00 Very High Very High Very High
Delta opioid receptors 21 100.00 Very High Very High Very High
Dynorphin 6 100.00 Very High Very High Very High
Morphine 39 99.98 Very High Very High Very High
adenocard 8 99.98 Very High Very High Very High
opioid receptor 41 99.96 Very High Very High Very High
agonist 64 99.82 Very High Very High Very High
Enkephalin 56 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 85 100.00 Very High Very High Very High
Smith-lemli-opitz Syndrome 6 99.82 Very High Very High Very High
Disease 71 99.40 Very High Very High Very High
INFLAMMATION 7 99.16 Very High Very High Very High
Neuroblastoma 21 98.84 Very High Very High Very High
Depression 19 98.72 Very High Very High Very High
Glioma 8 98.36 Very High Very High Very High
Dyskinesias 2 98.32 Very High Very High Very High
Apoptosis 5 98.14 Very High Very High Very High
Sprains And Strains 2 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, down-regulation of mu and delta receptors was homologous, because selective agonists down-regulated their respective receptors without effect on the heterologous opiate receptor.
Negative_regulation (down-regulation) of delta associated with agonist and opiate
1) Confidence 0.57 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.07 Pain Relevance 0.62
Pretreatment of SK-N-SH cells with beta-funaltrexamine prevented down-regulation of delta receptors in response to chronic exposure to morphine but did not affect down-regulation of delta receptors in response to D-Pen2,D-Pen5-enkephalin.
Negative_regulation (down-regulation) of delta in SK-N-SH associated with enkephalin and morphine
2) Confidence 0.57 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394999 Disease Relevance 0.07 Pain Relevance 1.20
Pretreatment of SK-N-SH cells with beta-funaltrexamine prevented down-regulation of delta receptors in response to chronic exposure to morphine but did not affect down-regulation of delta receptors in response to D-Pen2,D-Pen5-enkephalin.
Negative_regulation (down-regulation) of delta in SK-N-SH associated with enkephalin and morphine
3) Confidence 0.57 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394999 Disease Relevance 0.07 Pain Relevance 1.26
Down-regulation of mu receptors by the selective agonist PL017 was also attenuated by Tyr-W-MIF-1, but down-regulation of delta receptors by the selective agonist DPDPE was not.
Negative_regulation (down-regulation) of delta associated with agonist
4) Confidence 0.57 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454805 Disease Relevance 0.14 Pain Relevance 0.92
This study was designed to test the hypothesis that inhibition of agonist-induced delta-receptor down-regulation would block the development of opioid tolerance in a cell-based model.
Negative_regulation (regulation) of delta associated with tolerance, agonist and opioid
5) Confidence 0.57 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17159161 Disease Relevance 0 Pain Relevance 0.80
Combined blockade of kappa and delta receptors was without effect.
Negative_regulation (blockade) of delta
6) Confidence 0.57 Published 1992 Journal Brain Res. Section Abstract Doc Link 1334766 Disease Relevance 0.32 Pain Relevance 1.79
The diacylglycerol 1-oleoyl-2-acetyl-glycerol and bradykinin substituted for PMA but not carbachol, indicating that PKC activated physiologically may play a role in delta receptor down-regulation.
Negative_regulation (down-regulation) of delta associated with kinase c and bradykinin
7) Confidence 0.57 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1331757 Disease Relevance 0 Pain Relevance 0.49
Chromatin immunoprecipitation assays showed that the blockage of naloxone is achieved through down-regulation of transcription factor YY1.
Negative_regulation (regulation) of transcription factor YY1 associated with narcan
8) Confidence 0.46 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.48
Recent studies from our laboratory resolved two subtypes of the kappa 2 binding site, termed kappa 2a and kappa 2b, using guinea pig, rat, and human brain membranes depleted of mu and delta receptors by pretreatment with the site-directed acylating agents BIT (mu-selective) and FIT (delta-selective). 6 beta-Iodo-3,14-dihydroxy-17-cyclopropylmethyl-4,5 alpha-epoxymorphinan (IOXY), an opioid antagonist that has high affinity for kappa 2 sites, was radioiodinated to maximum specific activity (2200 Ci/mmol) and purified by high pressure liquid chromatography and used to characterize multiple kappa 2 binding sites.
Negative_regulation (depleted) of delta in brain associated with antagonist and opioid
9) Confidence 0.42 Published 1993 Journal Peptides Section Abstract Doc Link 8134311 Disease Relevance 0 Pain Relevance 0.30
Blacks displayed significantly lower nadir fibrinogen levels (0.57 +/- 0.62 versus 1.3 +/- 0.76 g/l, p less than 0.0001), greater delta fibrinogen (baseline-nadir) (2.7 +/- 1.1 versus 1.7 +/- 1.1 g/l, p less than 0.0001), and increased peak levels of fibrin(ogen) degradation products (837 +/- 865 versus 245 +/- 475 micrograms/ml, p less than 0.0001). rt-PA antigen levels tended to be higher in blacks than in whites (2.8 +/- 2.2 versus 2.2 +/- 3.2 micrograms/ml [p = 0.10] at the peak and 1.6 +/- 1.3 versus 0.99 +/- 1.4 micrograms/ml [p = 0.06] at the end of the maintenance infusion).
Negative_regulation (displayed) of delta
10) Confidence 0.42 Published 1991 Journal Circulation Section Abstract Doc Link 1898641 Disease Relevance 0.33 Pain Relevance 0.09
We observed a downregulation of the conventional (alpha, beta I, beta II, gamma) and the novel (delta, epsilon, eta) PKC isoforms in SD, but no change in the atypical isozyme (zeta).
Negative_regulation (downregulation) of delta associated with kinase c and depression
11) Confidence 0.42 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014175 Disease Relevance 1.17 Pain Relevance 0.98
In particular, a lack of desensitization of the delta receptor by morphine may contribute to our understanding of the molecular basis of development of morphine-induced tolerance and dependence.
Negative_regulation (desensitization) of delta associated with addiction, tolerance and morphine
12) Confidence 0.42 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9271350 Disease Relevance 0 Pain Relevance 1.14
When coadministered with 3 microM morphine, Tyr-W-MIF-1 dose-dependently attenuated morphine-induced down-regulation of both mu and delta receptors.
Negative_regulation (down-regulation) of delta associated with morphine
13) Confidence 0.42 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454805 Disease Relevance 0.15 Pain Relevance 0.93
Furthermore, we find that a delta receptor antagonist enhances both the potency and efficacy of the mu receptor signaling; likewise a mu antagonist enhances the potency and efficacy of the delta receptor signaling.
Negative_regulation (antagonist) of delta associated with antagonist and potency
14) Confidence 0.42 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069979 Disease Relevance 0.05 Pain Relevance 0.84
To further our understanding of the developmental and neurological processes that underlie the pathophysiology of this disorder, we have developed a mouse model of RSH/SLOS by disruption of the 3 beta-hydroxysterol Delta(7)-reductase gene.
Negative_regulation (disruption) of Delta associated with smith-lemli-opitz syndrome
15) Confidence 0.42 Published 2001 Journal Hum. Mol. Genet. Section Abstract Doc Link 11230174 Disease Relevance 1.16 Pain Relevance 0
Broad-spectrum anti-inflammatory drugs may be more effective, and include inhibitors of the enzymes phosphodiesterase-4, p38 mitogen-activated protein kinase, NF-kappaB kinase and phosphoinositide 3 kinase-gamma and -delta, but side effects will be a major limitation so that inhaled delivery may be necessary.
Negative_regulation (inhibitors) of delta associated with inflammation and cinod
16) Confidence 0.42 Published 2010 Journal Med Princ Pract Section Abstract Doc Link 20639653 Disease Relevance 0.88 Pain Relevance 0.40
Morphine down-regulated both mu and delta receptors, but its effects on each subtype could be dissociated by use of specific antagonists.
Negative_regulation (down-regulated) of delta associated with antagonist and morphine
17) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.17 Pain Relevance 0.92
Five inborn errors with consequences for bile acid biosynthesis have been described: 7-dehydrocholesterol 7-reductase deficiency, 3 beta-hydroxysteroid delta 5-oxidoreductase/isomerase deficiency, 3-oxo-delta 4-steroid 5 beta-reductase deficiency, sterol 27-hydroxylase deficiency (cerebrotendinous xanthomatosis), and peroxisomal disease(s) with absence of peroxisomes.
Negative_regulation (deficiency) of delta in bile associated with bile, van bogaert's disease and disease
18) Confidence 0.42 Published 1994 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 7824882 Disease Relevance 0.32 Pain Relevance 0.13
The agonists morphine and cyclazocine, which alone were unable to induce delta receptor down-regulation, did so in the presence of PMA.
Neg (unable) Negative_regulation (down-regulation) of delta associated with agonist and morphine
19) Confidence 0.42 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1331757 Disease Relevance 0.13 Pain Relevance 0.92
Bile acid therapy is important in most of these disorders and in the case of 3 beta-hydroxysteroid delta 5-oxidoreductase/isomerase deficiency and 3-oxo-delta 4-steroid 5 beta-reductase deficiency such therapy may save the life of the affected cholestatic infant.
Negative_regulation (deficiency) of delta in Bile associated with bile
20) Confidence 0.42 Published 1994 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 7824882 Disease Relevance 0.42 Pain Relevance 0.21

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