INT67170

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Context Info
Confidence 0.65
First Reported 1994
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 22
Total Number 44
Disease Relevance 9.35
Pain Relevance 7.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
ETA 8
granule cell 5
pore 4
molecular layer 2
plasma 1
Ednra (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 31 99.98 Very High Very High Very High
Glutamate 1078 99.50 Very High Very High Very High
agonist 5 99.48 Very High Very High Very High
qutenza 17 99.08 Very High Very High Very High
Hyperalgesia 6 99.06 Very High Very High Very High
Cancer pain 6 98.84 Very High Very High Very High
Neurotransmitter 198 96.44 Very High Very High Very High
Thermal hyperalgesia 21 94.96 High High
Dopamine 44 94.44 High High
Pain 19 94.44 High High
Disease Link Frequency Relevance Heat
Death 96 99.72 Very High Very High Very High
Neurological Disease 44 99.68 Very High Very High Very High
Sarcoma 3 99.20 Very High Very High Very High
Hyperalgesia 30 99.06 Very High Very High Very High
Cancer Pain 6 98.84 Very High Very High Very High
Hyperoxia 108 98.68 Very High Very High Very High
Pain 14 94.44 High High
Disease 30 93.44 High High
Breast Cancer 12 92.32 High High
Nociception 7 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that in a murine osteolytic 2472 sarcoma model of bone cancer pain, the 2472 sarcoma cells express high levels of ET-1, but express low or undetectable levels of endothelin A (ETAR) or B (ETBR) receptors whereas a subpopulation of sensory neurons express the ETAR and non-myelinating Schwann cells express the ETBR.
Gene_expression (express) of ETAR in sensory neurons associated with sarcoma and cancer pain
1) Confidence 0.65 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207337 Disease Relevance 1.17 Pain Relevance 0.61
Concerning side effects, Eta did not alter locomotor activity, body temperature, gastrointestinal transit and did not produce gastric lesions.
Neg (not) Gene_expression (produce) of Eta in body
2) Confidence 0.47 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18761072 Disease Relevance 0.11 Pain Relevance 0
The antagonism of the ETA receptors inhibits the ET-1-induced contraction in parenchymal strips, whereas this treatment is ineffective in isolated bronchi [38], indicating that the antagonist ETA receptors are expressed in greater density in the lung parenchyma, while the ETB receptors are expressed more markedly in the airways.
Gene_expression (expressed) of ETA in parenchyma associated with antagonist
3) Confidence 0.28 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.36 Pain Relevance 0.12
Two groups of animals kept in room air (group C, n = 8) or were exposed to hyperoxia for 60 h (group Hox, n = 10) were not subjected to ET-1 receptor blockade, dual ETA/ETB-receptor blocker TEZ was administered continuously for 6 days via an intraperitoneal pump (10 mg/kg/day) to two other groups of mice, likewise kept in room air (group CT, n = 6) or exposed to hyperoxia for 60 h (group HoxT, n = 7).
Gene_expression (blockade) of ETA associated with hyperoxia
4) Confidence 0.24 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.59 Pain Relevance 0
Administration of EtOH to B6C3F1 mice by gavage produces blood EtOH levels, behavioral changes, and endocrine changes similar to those that have been reported in human binge drinkers.
Gene_expression (produces) of EtOH in blood
5) Confidence 0.22 Published 1994 Journal Alcohol Alcohol Suppl Section Abstract Doc Link 8974365 Disease Relevance 0.09 Pain Relevance 0.06
In electrophysiological study, whole-cell patch-clamp recordings were performed to investigate the interaction of ET-1 and TRPV1 using human embryonic kidney 293 (HEK293) cells expressing endothelin type A receptor (ET(A)) and TRPV1.
Gene_expression (expressing) of ET in embryonic kidney
6) Confidence 0.21 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.68 Pain Relevance 0.91
Hyperalgesia induced by 5-HT was abolished by simultaneous injection of endothelin-1 or the endothelin ET(B) receptor agonist IRL 1620 (each at 30 pmol/paw).
Gene_expression (injection) of endothelin ET in paw associated with hyperalgesia and agonist
7) Confidence 0.16 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698200 Disease Relevance 0.81 Pain Relevance 0.95
In voltage-clamp experiments, 10 nM capsaicin evoked small inward currents in HEK293 cells expressing TRPV1 and ET(A).
Gene_expression (expressing) of ET associated with qutenza
8) Confidence 0.14 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.60 Pain Relevance 0.99
Incubation of ET-1 and intraplantar ET-1 evoked phosphorylation of TRPV1 in HEK293 cells expressing TRPV1 and ET(A) and the skin, respectively.
Gene_expression (expressing) of ET in skin
9) Confidence 0.14 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.27 Pain Relevance 0.75
In renal cells or granule neurons, the data suggest that part of the ET action, but not ET binding, relies on cholesterol or integrity of cholesterol containing microdomains: pretreatment with methyl-?
Gene_expression (action) of ET in neurons
10) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0
-cyclodextrin abolishes ET-induced Ca2+-rise in granule cell primary cultures (this study) as well as in renal cells [12].
Gene_expression (abolishes) of ET in granule cell
11) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0
In the 66 negative experiments, it was unclear whether ET had failed to produce an effect (may be no ET receptor was present in the recorded patch of membrane or the pore/channel activation occurred during the process of sealing of the patch pipette to the plasma membrane of granule cell).
Neg (no) Gene_expression (present) of ET receptor in granule cell
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0
Epsilon toxin (ET) is a protein of 30 kDa produced by Clostridium perfringens types B and D with a very high lethality (?
Gene_expression (produced) of ET
13) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.23 Pain Relevance 0
Clostridium perfringens Epsilon Toxin Targets Granule Cells in the Mouse Cerebellum and Stimulates Glutamate Release

Epsilon toxin (ET) produced by C. perfringens types B and D is a highly potent pore-forming toxin.

Gene_expression (produced) of ET in pore associated with glutamate
14) Confidence 0.09 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2948003 Disease Relevance 0.10 Pain Relevance 0.08
However, the causal link between pore formation and altered functions remains unclear: in conditions that prevent ET heptamerization ET can cause cell death [12].
Gene_expression (heptamerization) of ET in pore associated with death
15) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.48 Pain Relevance 0.27
100 experiments, ET (10?
Gene_expression (experiments) of ET
16) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0
0.7 pA, vs bicu + ET: 16.2+/?
Gene_expression (bicu) of ET
17) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.18
Under these conditions, ET staining in granule cell cultures appeared qualitatively similar to that observed without methyl-?
Gene_expression (staining) of ET in granule cell
18) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.19 Pain Relevance 0.04
ET-intoxicated animals express severe neurological disorders [1], [4], [16], [17] associated with a marked increase in neurotransmitter release (including glutamate and dopamine) and neuronal cell death [18]–[21].
Gene_expression (express) of ET in neuronal associated with dopamine, glutamate, neurotransmitter, neurological disease and death
19) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.45 Pain Relevance 0.29
The cerebellar white matter mainly composed of myelinated axons (including the Purkinje cells axons) and oligodendrocytes displayed a strong ET staining.


Gene_expression (staining) of ET in cerebellar white matter
20) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.08

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