INT67174

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Context Info
Confidence 0.56
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 10.72
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
endothelial cells 4
neuronal 1
blood vessels 1
hind limb 1
limb 1
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 3 99.64 Very High Very High Very High
tetrodotoxin 1 99.36 Very High Very High Very High
headache 13 99.32 Very High Very High Very High
ischemia 24 98.98 Very High Very High Very High
dorsal root ganglion 5 81.84 Quite High
Sciatic nerve 1 81.64 Quite High
Root ganglion neuron 1 75.00 Quite High
Migraine 1 60.56 Quite High
cINOD 12 53.12 Quite High
Botox 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 306 99.84 Very High Very High Very High
Mevalonate Kinase Deficiency 232 99.84 Very High Very High Very High
Headache 14 99.32 Very High Very High Very High
Cv Unclassified Under Development 48 98.98 Very High Very High Very High
Targeted Disruption 72 98.68 Very High Very High Very High
Increased Venous Pressure Under Development 24 98.34 Very High Very High Very High
Clostridium Infection 6 98.08 Very High Very High Very High
Cancer 1026 97.48 Very High Very High Very High
Death 102 93.48 High High
Stress 24 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rac1 depletion does not affect VEGF-receptor2 expression
Negative_regulation (depletion) of Rac1
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Moreover, a significant reduction of both Rac1 and Flk-1 mRNA and protein levels was achieved in pSico-Rac1 or pSico-Flk-1 transduced cells, respectively.
Negative_regulation (reduction) of Rac1
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.43 Pain Relevance 0
For example, a 50% loss of Rac1 in Tie2-Cre mice results in reduced neovascularization in the hind-limb ischemia model [24].
Negative_regulation (loss) of Rac1 in limb associated with ischemia
3) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.54 Pain Relevance 0.05
Therefore, deficiency of Rac1 in endothelial cells is not sufficient to alter neovasculatization in vivo, at least when ?
Negative_regulation (deficiency) of Rac1 in endothelial cells
4) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0
A beneficial effect of botulinum toxin on tension-type headache was reported in open-label studies but scientifically rigorous clinical studies are lacking.
Negative_regulation (effect) of botulinum toxin associated with headache
5) Confidence 0.42 Published 2004 Journal Pain Section Abstract Doc Link 15082132 Disease Relevance 0.38 Pain Relevance 0.38
RhoA, Cdc42 and Rac1 can be activated when GTP-bound, and inactivated, when GDP-bound.
Negative_regulation (inactivated) of Rac1
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.82 Pain Relevance 0
Rac1 mRNA and protein levels were reduced in aortic rings from both genotypes by approximately 85% after transfection with Rac1-specific siRNA (Figure 6C).
Negative_regulation (reduced) of Rac1
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
3-null endothelial cells is sufficient to reduce Rac1-GTP levels back to wild-type levels (Figure 1A, B).
Negative_regulation (reduce) of Rac1 in endothelial cells
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.76 Pain Relevance 0
3-null mice back to levels observed in wild-type mice either with or without depletion of Rac1.
Negative_regulation (depletion) of Rac1
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.20 Pain Relevance 0.05
Importantly, knockdown of Rac1 had no effect on VEGF-induced 3D chemotactic migration of wild-type endothelial cells, but did inhibit this mode of migration in ?
Negative_regulation (knockdown) of Rac1 in endothelial cells
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Our findings suggest that inhibition of Rac1 might be an effective anti-angiogenic therapeutic strategy in tumor blood vessels that display low levels of ?
Negative_regulation (inhibition) of Rac1 in blood vessels associated with cancer
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.33 Pain Relevance 0
For example, haploinsufficiency of Rac1 in Tie2-Cre mice results in the poor regulation of blood pressure, vasodilation and impaired hind limb ischemia-induced neovascularization, suggesting that a 50% loss of Rac1 in Tie2-Cre mice is sufficient to affect this process [24].
Negative_regulation (loss) of Rac1 in hind limb associated with ischemia and increased venous pressure under development
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.52 Pain Relevance 0.05
These results suggest that the lack of an inhibitory response to Rac1 loss in wild-type endothelial cells is not due to compensation by either Rac2, Rac3, Cdc42 or RhoA.
Negative_regulation (loss) of Rac1 in endothelial cells
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Short- and long-term results show the equal effectiveness of botulinum toxin A reconstituted in saline or in lidocaine.
Negative_regulation (effectiveness) of botulinum toxin
14) Confidence 0.40 Published 2007 Journal Br. J. Dermatol. Section Body Doc Link 17286630 Disease Relevance 0 Pain Relevance 0
When control and MKD cells were cultured in the absence of simvastatin followed by separation into membrane and soluble fractions, we observed somewhat higher levels of membrane-bound RhoA in MKD cells than in control cells (Fig. 1b, immunoblots), whereas membrane-bound Rac1 levels were slightly lower in MKD cells than in control cells (Fig.1g, immunoblots).
Negative_regulation (lower) of Rac1 associated with mevalonate kinase deficiency
15) Confidence 0.28 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.81 Pain Relevance 0
Although the relative decrease of membrane-bound Rac1 is similar for control and MKD cells, we also observed less membrane-bound Rac1 in MKD cells after incubation with simvastatin.
Negative_regulation (decrease) of Rac1 associated with mevalonate kinase deficiency
16) Confidence 0.28 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.55 Pain Relevance 0
Incubation with GGTI led to a reduction in membrane-bound RhoA and Rac1 that was similar for both control and MKD cells (Fig. 2b, g) and, in parallel, an increase in the levels of soluble RhoA and Rac1 (Fig. 2c and 2h).
Negative_regulation (reduction) of Rac1 associated with mevalonate kinase deficiency
17) Confidence 0.28 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.30 Pain Relevance 0
In the presence of simvastatin, there was a decrease in active membrane-bound Rac1 and an increase in active soluble Rac1, with MKD cells being more sensitive to lower concentrations of simvastatin than were control cells.


Negative_regulation (decrease) of Rac1 associated with mevalonate kinase deficiency
18) Confidence 0.28 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.39 Pain Relevance 0
We have found that apoptotic effects of statins are driven through inhibition of the small G proteins Rac-1 and RhoA.
Negative_regulation (inhibition) of proteins Rac-1 associated with apoptosis
19) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.72 Pain Relevance 0
(Figure 5b), whereas Rac-1 inhibition did not increase Smad activation, and even decreased such activation.
Negative_regulation (inhibition) of Rac-1
20) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.42 Pain Relevance 0

General Comments

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