INT67181

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.02
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
plasma 2
epithelial cells 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 23 67.04 Quite High
chemokine 1 64.32 Quite High
Pain 1 50.88 Quite High
Inflammatory response 3 28.56 Quite Low
tolerance 20 5.00 Very Low Very Low Very Low
nud 16 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
peptic ulcer disease 6 5.00 Very Low Very Low Very Low
bradykinin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperuricemia 1 100.00 Very High Very High Very High
Hypertension 22 98.80 Very High Very High Very High
Sickle Cell Anemia 8 98.22 Very High Very High Very High
Disorder Of Lipid Metabolism 6 98.14 Very High Very High Very High
Metabolic Syndrome 23 97.04 Very High Very High Very High
Insulin Resistance 38 95.82 Very High Very High Very High
Sprains And Strains 10 95.18 Very High Very High Very High
Ulcers 34 93.48 High High
Cancer 12 93.14 High High
Stomach Cancer 37 90.34 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Retrospective analyses of samples from gastric cancer patients have suggested an association with the cagA+/vacA+-positive genotype.33 Further studies have confirmed that a risk for both cancer and peptic ulcer is associated particularly with the cagA/vacA s1m1 genotype, but rarely with strains carrying the vacA s2m2 polymorphism.34,35 However, the cagA gene does not act alone, because delivery of the CagA protein into epithelial cells appears to be dependent on a secretion system encoded for by the adjacent cluster of genes, the cag PAI.36 After the CagA protein is injected into the host cell cytoplasm, it is tyrosine phosphorylated by host Src kinases and subsequently changes the epithelial morphology.37–41 CagA in strains from distinct geographic populations appears to be phosphorylated to a different degree, resulting in graded effects on intracellular signaling.42,43
Positive_regulation (injected) of Positive_regulation (cag) of PAI in epithelial cells associated with cancer, ulcers, sprains and strains and stomach cancer
1) Confidence 0.49 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780612 Disease Relevance 0.73 Pain Relevance 0.07
Over time, insulin resistance is associated with more components of the metabolic syndrome (Table 1) including, low high density lipoprotein (HDL) cholesterol level, hypertension, increased vascular production of reactive oxygen species, increased plasma PAI-1–mediated thrombotic tendency, hyperuricemia, high triglyceride levels and elevation of oxidation-prone small dense low-density lipoprotein (LDL) cholesterol levels.
Positive_regulation (increased) of Positive_regulation (elevation) of PAI-1 in plasma associated with hyperuricemia, hypertension, metabolic syndrome, insulin resistance and disorder of lipid metabolism
2) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.58 Pain Relevance 0.03
In all SCD patients, baseline levels of t-PA antigen were comparable to those in controls, whereas concentrations of PAI-1 antigen were significantly increased, either in the steady state (89.7 +/- 26.3 ng/ml, p < 0.0001) or in crisis (75.0 +/- 24.8 ng/ml, p < 0.0001).
Positive_regulation (increased) of Positive_regulation (concentrations) of PAI-1 associated with sickle cell anemia
3) Confidence 0.06 Published 1996 Journal Hematol Cell Ther Section Abstract Doc Link 8974793 Disease Relevance 0.71 Pain Relevance 0.05

General Comments

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