INT67188

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 4.58
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
OPLL 3
OPLL 2
canal 1
OPLL (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 23 96.80 Very High Very High Very High
imagery 7 91.20 High High
Sciatica 6 88.76 High High
Spinal cord 77 77.28 Quite High
antagonist 21 75.00 Quite High
agonist 14 69.72 Quite High
Osteoarthritis 7 26.08 Quite Low
Pain 115 5.00 Very Low Very Low Very Low
Facet joint 15 5.00 Very Low Very Low Very Low
iatrogenic 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pathologic Constriction 50 99.48 Very High Very High Very High
Spondylosis 5 99.08 Very High Very High Very High
Heterotopic Ossification 107 98.60 Very High Very High Very High
Seronegative Spondarthritis 10 96.80 Very High Very High Very High
Nerve Root Compression 6 88.76 High High
Rheumatic Diseases 2 86.56 High High
Low Back Pain 29 81.32 Quite High
Calcification 1 80.28 Quite High
Spinal Cord Diseases 99 79.00 Quite High
Osteoporosis 56 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACS with OPLL may represent an early form of the generation of classic OPLL in younger symptomatic individuals, which may be successfully addressed with an anterior surgical approach.
Gene_expression (generation) of OPLL in OPLL associated with spondylosis
1) Confidence 0.52 Published 1996 Journal J Spinal Disord Section Abstract Doc Link 8976487 Disease Relevance 0.57 Pain Relevance 0.09
Multiple authors including an orthopedic professor, an orthopedic surgery chief resident, and an orthopedic surgery junior resident performed the diagnosis of OPLL.
Gene_expression (diagnosis) of OPLL
2) Confidence 0.33 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.22 Pain Relevance 0.10
Enhanced expression of BMPRS at the nonossified ligament in OPLL patients suggests that these cells have a greater potential to differentiate into osteogenic cells than ligament cells from non-OPLL patients [38].
Gene_expression (expression) of OPLL in ligament
3) Confidence 0.33 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.07 Pain Relevance 0.11
are present in ossifying matrix and chondrocytes are present adjacent to cartilaginous areas of OPLL tissues, and that BMP-2 is also localized in mesenchymal cells with fibroblastic features in the immediate vicinity of the cartilaginous areas, and that nonossified ligaments do not contain either of these growth factors.
Gene_expression (tissues) of OPLL in ligaments
4) Confidence 0.33 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.35 Pain Relevance 0
A substitution, is significantly associated with OPLL, and the functional variant results in altered splicing, which is protective in the pathogenesis of OPLL [10].
Gene_expression (protective) of OPLL
5) Confidence 0.33 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.15 Pain Relevance 0.04
Furthermore, the analysis adjusted for gender showed that the Ser87Ser (A/G) polymorphism in male patients and in female patients showed no statistical difference between the OPLL groups and the control groups.
Gene_expression (groups) of OPLL
6) Confidence 0.33 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.33 Pain Relevance 0
A substitution, is significantly associated with OPLL, and the functional variant results in altered splicing, which is protective in the pathogenesis of OPLL [10].
Gene_expression (protective) of OPLL
7) Confidence 0.33 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.15 Pain Relevance 0.04
The present results indicate that the “G” allele promotes the extent of OPLL, whereas the “A” allele restricts ectopic ossification in the cervical spine in OPLL patients.
Gene_expression (promotes) of OPLL in spine associated with heterotopic ossification
8) Confidence 0.33 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.18 Pain Relevance 0
Recently, nucleotide pyrophosphatase (NPPS) was implicated in the aetiology of OPLL: an Npps mutation was found to cause OPLL in mice, and an association between a polymorphism of the human NPPS gene and OPLL was identified.
Gene_expression (polymorphism) of OPLL in OPLL
9) Confidence 0.27 Published 2003 Journal Rheumatology (Oxford) Section Abstract Doc Link 12509614 Disease Relevance 1.08 Pain Relevance 0.74
In most cases, symptomatic regrowth at the decompressed levels is unlikely because the canal diameter is made so large that a modest amount of OPLL expansion will not cause recurrent stenosis.
Gene_expression (expansion) of OPLL in canal associated with pathologic constriction
10) Confidence 0.08 Published 2008 Journal Asian Spine Journal Section Body Doc Link PMC2852088 Disease Relevance 0.27 Pain Relevance 0
However, because the OPLL is not resected with laminoplasty, the potential remains for growth and expansion of OPLL over time.
Neg (not) Gene_expression (resected) of OPLL
11) Confidence 0.08 Published 2008 Journal Asian Spine Journal Section Body Doc Link PMC2852088 Disease Relevance 0.32 Pain Relevance 0
Progression of OPLL
Gene_expression (Progression) of OPLL
12) Confidence 0.08 Published 2008 Journal Asian Spine Journal Section Body Doc Link PMC2852088 Disease Relevance 0.39 Pain Relevance 0
However, because the OPLL is not resected with laminoplasty, the potential remains for growth and expansion of OPLL over time.
Gene_expression (expansion) of OPLL
13) Confidence 0.08 Published 2008 Journal Asian Spine Journal Section Body Doc Link PMC2852088 Disease Relevance 0.27 Pain Relevance 0
But if the OPLL expands longitudinally to include previously undecompressed adjacent segments, symptomatic cord compression may occur.
Gene_expression (expands) of OPLL
14) Confidence 0.08 Published 2008 Journal Asian Spine Journal Section Body Doc Link PMC2852088 Disease Relevance 0.23 Pain Relevance 0

General Comments

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