INT67190

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 18.80
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Muc2) proteinaceous extracellular matrix (Muc2) nucleus (Muc2)
cytoplasm (Muc2)
Anatomy Link Frequency
pancreas 3
goblet cells 3
CSN 1
liver 1
epithelium 1
Muc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 7 99.60 Very High Very High Very High
Chronic pancreatitis 14 98.24 Very High Very High Very High
Bile 73 93.48 High High
imagery 30 88.08 High High
tolerance 3 86.20 High High
Inflammation 66 84.76 Quite High
Serotonin 20 82.04 Quite High
palliative 8 71.52 Quite High
Inflammatory response 6 50.48 Quite High
antagonist 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 637 99.92 Very High Very High Very High
Cholangiocarcinoma 27 99.74 Very High Very High Very High
Mucinous Cystadenoma 18 99.68 Very High Very High Very High
Adenocarcinoma 83 99.46 Very High Very High Very High
Villous Adenoma 2 99.08 Very High Very High Very High
Pancreatic Cancer 24 98.96 Very High Very High Very High
Pseudomyxoma Peritonei 8 98.64 Very High Very High Very High
Pancreatitis 14 98.24 Very High Very High Very High
Malignant Neoplastic Disease 119 97.76 Very High Very High Very High
Rhinitis 6 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Probiotics prevent pathogen adherence and invasion of the epithelium, partly by blocking adherence sites but also by upregulating gene expression of MUC2 and of antimicrobial peptides.
Gene_expression (expression) of MUC2 in epithelium
1) Confidence 0.78 Published 2009 Journal Trop Gastroenterol Section Abstract Doc Link 19760989 Disease Relevance 0.23 Pain Relevance 0
In addition, loxoprofen downregulated Muc2 expression, and this response was totally reversed by lafutidine mediated by CSN.
Gene_expression (expression) of Muc2 in CSN
2) Confidence 0.57 Published 2010 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 20586851 Disease Relevance 0 Pain Relevance 0
It also expresses MUC2 and CDX2 but not MUC1 (Fig. 1a,b).
Neg (not) Gene_expression (expresses) of MUC2
3) Confidence 0.35 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2063564 Disease Relevance 0.85 Pain Relevance 0
The tumor cells express MUC1 and MUC2 inconsistently (Fig. 1e,f).
Gene_expression (express) of MUC2 associated with cancer
4) Confidence 0.35 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2063564 Disease Relevance 0.84 Pain Relevance 0
An altered glycosylation, sulfatation, expression of MUC2 and localization of MUC1 have been documented [19,22].
Gene_expression (expression) of MUC2
5) Confidence 0.24 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.54 Pain Relevance 0.20
In normal pancreas (n = 5), MUC1 apomucin was expressed in ducts and some acini, but there was no expression of MUC2, MUC3, or MUC5/6.
Gene_expression (expression) of MUC2 in ducts
6) Confidence 0.22 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.48 Pain Relevance 0.10
The epithelial expression of apomucins MUC1, MUC2, MUC3, and MUC5/6 was examined in normal pancreas and in pancreatic lesions, using immunohistochemical methods.
Gene_expression (expression) of MUC2 in pancreas
7) Confidence 0.22 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.34 Pain Relevance 0.08
In invasive ductal adenocarcinoma of the pancreas (n = 25), expression of MUC1, MUC2, MUC3, and MUC5/6 apomucins was found in 25/25 (100 percent), 1/25 (4 percent), 20/25 (80 percent), and 24/25 (96 percent) cases, respectively.
Gene_expression (expression) of MUC2 in pancreas associated with adenocarcinoma
8) Confidence 0.22 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.86 Pain Relevance 0.07
In intraductal papillary-mucinous neoplasm (IPMN) of the pancreas (n = 9), MUC1, MUC2, MUC3, and MUC5/6 apomucins were expressed in 8/9 (89 percent), 0/9 (0 per cent), 4/9 (44 per cent), and 9/9 (100 per cent) case, respectively.
Gene_expression (expressed) of MUC2 in pancreas associated with cancer
9) Confidence 0.22 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.73 Pain Relevance 0.09
In positive cases, MUC1 apomucin expression was noted in the cell membrane facing the ductal or neoplastic lumina, while expression of MUC2, MUC3, and MUC5/6 apomucins was found in the cytoplasm.
Gene_expression (expression) of MUC2
10) Confidence 0.22 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.83 Pain Relevance 0.06
In pancreatic mucinous cystadenoma (n = 8), MUC1, MUC2, MUC3, and MUC5/6 apomucins were expressed in 7/8 (88 percent), 0/8 (0 percent), (25 percent), and 3/8 (38 percent) cases, respectively.
Gene_expression (expressed) of MUC2 associated with mucinous cystadenoma
11) Confidence 0.22 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.76 Pain Relevance 0.08
These results suggest that MUC3 and MUC5/6 apomucins newly emerge during the neoplastic transformation of pancreatic mucinous cystadenoma and IPMN and during pancreatic ductal carcinogenesis, while MUC1 apomucin remains positive and MUC2 apomucin remains almost negative during neoplastic transformation.
Gene_expression (negative) of MUC2 associated with mucinous cystadenoma and cancer
12) Confidence 0.19 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.67 Pain Relevance 0
Sasaki et al [14] report that intrahepatic cholangiocarcinomas extensively expressed MUC1 apomucin and focally expressed MUC2 apomucin.
Gene_expression (expressed) of MUC2 associated with cholangiocarcinoma
13) Confidence 0.17 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1618388 Disease Relevance 1.37 Pain Relevance 0.16
Carcinogenesis via BilIN was characterized by MUC2-/CK7+/CK20-with increasing MUC1 expression.
Gene_expression (expression) of MUC2
14) Confidence 0.15 Published 2006 Journal J. Hepatol. Section Body Doc Link 16360234 Disease Relevance 0.15 Pain Relevance 0
METHODS: We immunohistochemically examined expression patterns of MUC1, MUC2, MUC5AC, cytokeratin 7 (CK7), and CK20 in BilIN, IPN-B, and ICC in 110 cases of hepatolithiasis.
Spec (examined) Gene_expression (expression) of MUC2
15) Confidence 0.14 Published 2006 Journal J. Hepatol. Section Body Doc Link 16360234 Disease Relevance 0.18 Pain Relevance 0
METHODS: We immunohistochemically examined expression patterns of MUC1, MUC2, MUC5AC, cytokeratin 7 (CK7), and CK20 in BilIN, IPN-B, and ICC in 110 cases of hepatolithiasis.
Spec (examined) Gene_expression (patterns) of MUC2
16) Confidence 0.14 Published 2006 Journal J. Hepatol. Section Body Doc Link 16360234 Disease Relevance 0.18 Pain Relevance 0
This is a neoplastic disease of MUC2-expressing goblet cells, which collectively overexpress MUC2 because of their increase in number.
Gene_expression (expressing) of MUC2 in goblet cells associated with cancer
17) Confidence 0.13 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1182398 Disease Relevance 1.20 Pain Relevance 0.08
Goblet cells of the appendix express both MUC2 and MUC5AC mucins but primary ovarian mucinous tumors only express MUC5AC.
Gene_expression (express) of MUC2 in appendix associated with cancer
18) Confidence 0.13 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1182398 Disease Relevance 1.29 Pain Relevance 0.08
More specifically, Shimonishi et al [15] report that epithelial hypersecretion of sialomucin rather than sulfomucin is prevalent in intraductal papillary neoplasia of the liver (IPN-L), as well is the expression of cytokeratin (CK) 20, MUC2 and nuclear p53 immunostaining.
Gene_expression (expression) of MUC2 in liver associated with cancer and ipn
19) Confidence 0.13 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1618388 Disease Relevance 1.09 Pain Relevance 0.26
Higashi et al [16] suggest that MUC1 expression from invasive cholangiocarcinomas is associated with poor patient outcome, in contrary to expression of non-sialylated MUC2 mucin which is thought to be a favourable prognostic indicator.
Gene_expression (expression) of MUC2 associated with cholangiocarcinoma
20) Confidence 0.13 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1618388 Disease Relevance 1.05 Pain Relevance 0.27

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