INT67191

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Context Info
Confidence 0.29
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 9.93
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biological_process (Muc3)
Anatomy Link Frequency
pancreas 3
ducts 2
urinary bladder 1
Muc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 9 98.72 Very High Very High Very High
Bile 15 88.60 High High
IPN 1 78.24 Quite High
Pain 1 55.48 Quite High
Dysuria 1 54.28 Quite High
imagery 5 45.04 Quite Low
palliative 2 28.48 Quite Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 67 100.00 Very High Very High Very High
Mucinous Cystadenoma 18 100.00 Very High Very High Very High
Adenocarcinoma 33 99.52 Very High Very High Very High
Cholangiocarcinoma 6 99.40 Very High Very High Very High
Pancreatitis 9 98.72 Very High Very High Very High
Hyperplasia 19 98.54 Very High Very High Very High
Cystadenocarcinoma 1 89.60 High High
Mucinous Adenocarcinoma 6 83.92 Quite High
Carcinoma 7 80.76 Quite High
Malignant Neoplastic Disease 20 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In positive cases, MUC1 apomucin expression was noted in the cell membrane facing the ductal or neoplastic lumina, while expression of MUC2, MUC3, and MUC5/6 apomucins was found in the cytoplasm.
Gene_expression (expression) of MUC3
1) Confidence 0.29 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.83 Pain Relevance 0.06
In pancreatic mucinous cystadenoma (n = 8), MUC1, MUC2, MUC3, and MUC5/6 apomucins were expressed in 7/8 (88 percent), 0/8 (0 percent), (25 percent), and 3/8 (38 percent) cases, respectively.
Gene_expression (expressed) of MUC3 associated with mucinous cystadenoma
2) Confidence 0.29 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.76 Pain Relevance 0.08
Atypical mucous duct hyperplasia near cancer cells consistently expressed MUC1 apomucin and occasionally expressed MUC3 and MUC5/6.
Gene_expression (expressed) of MUC3 in duct associated with cancer and hyperplasia
3) Confidence 0.29 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.86 Pain Relevance 0.06
In invasive ductal adenocarcinoma of the pancreas (n = 25), expression of MUC1, MUC2, MUC3, and MUC5/6 apomucins was found in 25/25 (100 percent), 1/25 (4 percent), 20/25 (80 percent), and 24/25 (96 percent) cases, respectively.
Gene_expression (expression) of MUC3 in pancreas associated with adenocarcinoma
4) Confidence 0.29 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.86 Pain Relevance 0.07
In intraductal papillary-mucinous neoplasm (IPMN) of the pancreas (n = 9), MUC1, MUC2, MUC3, and MUC5/6 apomucins were expressed in 8/9 (89 percent), 0/9 (0 per cent), 4/9 (44 per cent), and 9/9 (100 per cent) case, respectively.
Gene_expression (expressed) of MUC3 in pancreas associated with cancer
5) Confidence 0.29 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.73 Pain Relevance 0.09
The epithelial expression of apomucins MUC1, MUC2, MUC3, and MUC5/6 was examined in normal pancreas and in pancreatic lesions, using immunohistochemical methods.
Gene_expression (expression) of MUC3 in pancreas
6) Confidence 0.29 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.35 Pain Relevance 0.08
These results suggest that MUC3 and MUC5/6 apomucins newly emerge during the neoplastic transformation of pancreatic mucinous cystadenoma and IPMN and during pancreatic ductal carcinogenesis, while MUC1 apomucin remains positive and MUC2 apomucin remains almost negative during neoplastic transformation.
Gene_expression (positive) of MUC3 associated with mucinous cystadenoma and cancer
7) Confidence 0.25 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.83 Pain Relevance 0.05
In normal pancreas (n = 5), MUC1 apomucin was expressed in ducts and some acini, but there was no expression of MUC2, MUC3, or MUC5/6.
Gene_expression (expression) of MUC3 in ducts
8) Confidence 0.25 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.48 Pain Relevance 0.10
These results suggest that MUC3 and MUC5/6 apomucins newly emerge during the neoplastic transformation of pancreatic mucinous cystadenoma and IPMN and during pancreatic ductal carcinogenesis, while MUC1 apomucin remains positive and MUC2 apomucin remains almost negative during neoplastic transformation.
Gene_expression (negative) of MUC3 associated with mucinous cystadenoma and cancer
9) Confidence 0.25 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8976874 Disease Relevance 0.83 Pain Relevance 0.05
In addition, cholangiocarcinoma of the hilar type frequently expressed MUC3 apomucin, while MUC5/6 apomucin was more frequently expressed in well-differentiated tumors.
Gene_expression (expressed) of MUC3 associated with cholangiocarcinoma and cancer
10) Confidence 0.09 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1618388 Disease Relevance 1.28 Pain Relevance 0.16
Regarding immunohistochemistry, adenocarcinoma of the urinary bladder expresses CEA, CDX-2, MUC-1, MUC-2 and MUC-3, same as colonic adenocarcinoma.
Gene_expression (expresses) of MUC-3 in urinary bladder associated with adenocarcinoma
11) Confidence 0.02 Published 2010 Journal Cases J Section Body Doc Link PMC2824640 Disease Relevance 2.14 Pain Relevance 0.11

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