INT67195

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.98
Pain Relevance 4.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
plasma 2
CSF 2
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 162 100.00 Very High Very High Very High
Neuropeptide 7 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
rheumatoid arthritis 11 99.84 Very High Very High Very High
Migraine 14 99.64 Very High Very High Very High
Opioid 5 99.46 Very High Very High Very High
headache 12 99.12 Very High Very High Very High
peptic ulcer disease 1 97.88 Very High Very High Very High
opioid receptor 5 97.48 Very High Very High Very High
central sensitization 1 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 167 100.00 Very High Very High Very High
Necrosis 4 99.88 Very High Very High Very High
Rheumatoid Arthritis 11 99.84 Very High Very High Very High
Headache 25 99.64 Very High Very High Very High
Somatostatinoma 4 98.48 Very High Very High Very High
Disease 85 97.88 Very High Very High Very High
Prolactinoma 47 97.78 Very High Very High Very High
Ulcers 2 97.72 Very High Very High Very High
Malignant Neoplastic Disease 18 97.60 Very High Very High Very High
Infection 2 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum somatostatin levels were reduced in RA patients between 45 and 55 yrs but reached a significant reduction (p less than 0.0001) in RA patients, 55 years and older compared to age-matched individuals from the control group.
Negative_regulation (reduced) of Gene_expression (levels) of somatostatin associated with rheumatoid arthritis and somatostatin
1) Confidence 0.42 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 14977577 Disease Relevance 0.88 Pain Relevance 0.67
In the same region of the opioid group there is correlated mosaicism between somatostatin receptors three and five, and the beta-2 adrenergic receptor of group 17.
Negative_regulation (mosaicism) of Gene_expression (receptors) of somatostatin associated with somatostatin and opioid
2) Confidence 0.41 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0 Pain Relevance 0.32
Although it seems a paradox to treat patients with symptoms related to elevated SST levels with a somatostatinoma, in 1998 Angeletti et al showed that octreotide treatment was effective in reducing plasma levels of somatostatin and improving the related symptoms in three patients with metastatic somatostatinomas [48].
Negative_regulation (reducing) of Gene_expression (levels) of somatostatin in plasma associated with somatostatin and somatostatinoma
3) Confidence 0.35 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.34 Pain Relevance 0.28
Moreover, decreased expression of neuropeptides and, particularly, negative staining for enkephalins, somatostatin, pancreatic polypeptide, and VIP have been associated with malignancy [18].
Negative_regulation (decreased) of Gene_expression (expression) of somatostatin associated with malignant neoplastic disease, somatostatin, neuropeptide and enkephalin
4) Confidence 0.22 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 1.26 Pain Relevance 0.31
An in vitro study in prolactinomas cells has demonstrated a stronger inhibition of prolactin with pasireotide than with octreotide, and that the inhibition of prolactin release was related to the expression level of sst5 [29].
Negative_regulation (inhibition) of Gene_expression (expression) of sst5 associated with prolactinoma
5) Confidence 0.17 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 0.73 Pain Relevance 0.45
Based on experimental findings, it can be postulated that reduced CSF levels of GDNF and somatostatin in both CM and PCM + PAAH patients can contribute to sustained central sensitization underlying chronic head pain.
Negative_regulation (reduced) of Gene_expression (levels) of somatostatin in CSF associated with central sensitization, migraine, somatostatin and headache
6) Confidence 0.14 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16556241 Disease Relevance 2.09 Pain Relevance 2.58
BACKGROUND & AIMS: Helicobacter pylori infection in patients who have peptic ulcer disease is associated with altered regulation of gastric secretion, hypergastrinemia, and diminished somatostatin expression in gastric mucosa.
Negative_regulation (diminished) of Gene_expression (expression) of somatostatin associated with necrosis, cancer, peptic ulcer disease, ulcers, somatostatin, disease and infection
7) Confidence 0.10 Published 1997 Journal Gastroenterology Section Abstract Doc Link 8978352 Disease Relevance 0.68 Pain Relevance 0.27

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