INT6722

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Context Info
Confidence 0.45
First Reported 1984
Last Reported 1992
Negated 2
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.17
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
neocortex 2
brain 2
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 99.64 Very High Very High Very High
opiate 2 99.56 Very High Very High Very High
agonist 2 99.28 Very High Very High Very High
Enkephalin 4 98.96 Very High Very High Very High
antagonist 3 98.80 Very High Very High Very High
Dynorphin 2 93.32 High High
Cholecystokinin 1 91.96 High High
Endogenous opioid 3 86.32 High High
Opioid 1 85.60 High High
Antinociceptive 1 84.72 Quite High
Disease Link Frequency Relevance Heat
Injury 2 88.16 High High
Catalepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Saturation studies at 37 degrees C revealed that beta-endorphin binding was time dependent.
Regulation (dependent) of beta-endorphin Binding (binding) of
1) Confidence 0.45 Published 1992 Journal Nephron Section Abstract Doc Link 1331832 Disease Relevance 0.08 Pain Relevance 0.28
Moreover, ablation of a similar amount of occipital neocortex did neither affect beta-endorphin actions nor the interactions of CCK-8.
Neg (neither) Regulation (affect) of beta-endorphin Neg (nor) Binding (actions) of in neocortex
2) Confidence 0.42 Published 1985 Journal Peptides Section Abstract Doc Link 3162160 Disease Relevance 0 Pain Relevance 0.09
The binding of [125I]beta-endorphin was not affected by either opiate agonists or antagonists.
Neg (not) Regulation (affected) of beta-endorphin Binding (binding) of associated with antagonist, agonist and opiate
3) Confidence 0.39 Published 1992 Journal Nephron Section Abstract Doc Link 1331832 Disease Relevance 0.09 Pain Relevance 0.28
The portion of [3H]-beta-endorphin binding that is inhibited under these conditions appears to be equally sensitive to both morphine and the enkephalin and may correspond to mu1 sites.
Regulation (sensitive) of beta-endorphin Binding (binding) of associated with enkephalin and morphine
4) Confidence 0.21 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6092561 Disease Relevance 0 Pain Relevance 0.85
To explore further the interaction of 3B4F11 with the beta-endorphin receptor, the effect of the Fab fragment on 125I-beta-endorphin cross-linking to rat brain membranes was examined. 125I-beta-endorphin was covalently bound to three major species of approximate molecular weights 108,000, 73,000, and 49,000.
Spec (examined) Regulation (effect) of 125I-beta-endorphin Binding (cross-linking) of in brain
5) Confidence 0.16 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 2848185 Disease Relevance 0 Pain Relevance 0.25

General Comments

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