INT67225

Context Info Confidence 0.28 First Reported 1996 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.30 Pain Relevance 0.17

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2) extracellular space (Apoa2) extracellular region (Apoa2) cellular_component (Apoa2)

Apoa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 18 76.56 anesthesia 1 70.32 Inflammation 4 63.60 Inflammatory mediators 2 37.44 Angina 1 5.00

Disease Link Frequency Relevance Heat Wound Healing 1 98.60 Diabetes Mellitus 21 87.84 Disorder Of Lipid Metabolism 5 81.52 Injury 6 77.92 Cardiovascular Disease 10 77.44 INFLAMMATION 8 63.60 Coronary Artery Disease 2 57.32 Atherosclerosis 7 52.24 Hyperlipidemia 3 21.52 Myocardial Infarction 22 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because these data are consistent with those observed after excisional wounding, temporal changes in AII receptor expression may be integral to the process of wound healing.

Positive_regulation (changes) of Gene_expression (expression) of AII receptor associated with wound healing

1) Confidence 0.28 Published 1996 Journal J Invest Surg Section Abstract Doc Link 8981218 Disease Relevance 0.51 Pain Relevance 0.07

They have also shown that pioglitazone increases apoA-II synthesis and mRNA expression in HepG2 cells.

Positive_regulation (increases) of Gene_expression (synthesis) of apoA-II

2) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2729049 Disease Relevance 0.78 Pain Relevance 0.10

General Comments

This test has worked.