INT67227

Context Info Confidence 0.26 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.31 Pain Relevance 0.25

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2) extracellular space (Apoa2) extracellular region (Apoa2) cellular_component (Apoa2)

Anatomy Link Frequency cardiovascular system 2 Apoa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 1 94.48 Kinase C 10 88.36 Bioavailability 5 62.68 cva 3 57.04 aspirin 1 54.68 antagonist 7 36.24 Inflammation 5 5.00 Migraine 2 5.00 Calcium channel 2 5.00 cytokine 1 5.00

Disease Link Frequency Relevance Heat Injury 6 100.00 Stress 15 96.60 Increased Venous Pressure Under Development 27 87.88 Renal Disease 4 81.92 Hyperglycemia 9 70.88 Aging 6 69.68 Pressure And Volume Under Development 18 69.24 Hyperlipidemia 11 68.68 Diabetes Mellitus 29 67.80 Cv General 3 Under Development 3 57.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The levels of 125I-Sar1.Ile8-AII bound to membrane preparations of the wound tissues decreased at early time points (from 0.5 to 4 h), increased from day 1 to day 7, and returned to nonsurgical levels by day 10.

Positive_regulation (increased) of Ile8-AII Binding (bound) of associated with injury

1) Confidence 0.26 Published 1996 Journal J Invest Surg Section Abstract Doc Link 8981218 Disease Relevance 0.53 Pain Relevance 0.09

In these effects an activated ET is likely to mediate the activity of the AII through NOX activation as AII-evoked expression of ET-1 in adventitial fibroblasts appears to be mediated, at least in part, by NOX.66 The mitochondrial ROS is responsible to mediate the activity of ET-1 in the cardiovascular system.67 The vascular activity of AII is closely related to ET-1, coronary vasoconstriction by ?

Positive_regulation (mediate) of AII Binding (activity) of in cardiovascular system associated with increased venous pressure under development

2) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.78 Pain Relevance 0.16

General Comments

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