INT67237

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Context Info
Confidence 0.00
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.49
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm1) plasma membrane (Grm1) nucleus (Grm1)
signal transducer activity (Grm1)
Anatomy Link Frequency
T cells 2
anterior 1
neurons 1
CNS 1
Grm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 24 100.00 Very High Very High Very High
Thalamus 39 99.40 Very High Very High Very High
Inflammation 10 98.28 Very High Very High Very High
Central nervous system 3 98.16 Very High Very High Very High
Dorsal horn neuron 2 96.20 Very High Very High Very High
antagonist 11 95.88 Very High Very High Very High
intrathecal 5 93.16 High High
agonist 20 92.56 High High
Glutamate 15 88.56 High High
Pain 4 82.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 98.28 Very High Very High Very High
Nociception 3 97.84 Very High Very High Very High
Neurological Disease 1 85.36 High High
Pain 2 82.80 Quite High
Depression 2 82.72 Quite High
Anxiety Disorder 1 81.44 Quite High
Schizophrenia 6 79.44 Quite High
Epilepsy 1 76.24 Quite High
Disease 8 74.08 Quite High
Cognitive Disorder 7 50.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This potentiation is not associated with increased mGlu1 or mGlu5 receptor expression but is associated with increased levels of phosphorylated ERK in dorsal horn neurons.
mGlu1 Binding (associated) of in neurons associated with dorsal horn neuron
1) Confidence 0.00 Published 2004 Journal Pain Section Abstract Doc Link 15327816 Disease Relevance 0.56 Pain Relevance 0.57
Because of the wide diversity, heterogeneous distribution, and diverse physiological roles of mGluR subtypes, the opportunity exists for developing therapeutic agents that selectively interact with mGluRs involved in only one or a limited number of CNS functions.
mGluR Binding (interact) of in CNS associated with central nervous system
2) Confidence 0.47 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0.68 Pain Relevance 0.44
Metabotropic glutamate receptor 1 (mGluR1) is expressed in the dendrites of M/T cells and is thought to participate in intraglomerular interactions among M/T cells.
Metabotropic glutamate receptor 1 Binding (interactions) of in T cells associated with glutamate receptor
3) Confidence 0.37 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19164106 Disease Relevance 0 Pain Relevance 0.18
Metabotropic glutamate receptor 1 (mGluR1) is expressed in the dendrites of M/T cells and is thought to participate in intraglomerular interactions among M/T cells.
mGluR1 Binding (interactions) of in T cells associated with glutamate receptor
4) Confidence 0.37 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19164106 Disease Relevance 0 Pain Relevance 0.17
Previous studies have shown that the ionotropic NR1 and metabotropic mGluR1 glutamate receptor subtypes are the most abundant in the dorsal thalamus, and the ventral anterior nucleus specifically [93], [94].
mGluR1 Binding (abundant) of in anterior associated with glutamate receptor and thalamus
5) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1952177 Disease Relevance 0 Pain Relevance 0.24
Under conditions in which buprenorphine and dezocine produced submaximal antinociceptive effects, these drugs were assessed after pretreatment with the mGluR1 antagonist JNJ16259685, the mGluR5 antagonist MPEP, the mGluR2/3 antagonist LY341495, and for comparison, the N-methyl-D-aspartate (NMDA) receptor antagonist LY235959.
mGluR1 Binding (pretreatment) of
6) Confidence 0.07 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18392754 Disease Relevance 0 Pain Relevance 0
It is suggested that a possible interaction between NMDA and mGluR1 is a critical event in the maintenance of persistent nociception.
mGluR1 Binding (interaction) of associated with nociception
7) Confidence 0.01 Published 1996 Journal Neuroreport Section Abstract Doc Link 8981459 Disease Relevance 0.25 Pain Relevance 0.34

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