INT67248

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 12
Total Number 17
Disease Relevance 13.51
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TACC2) Golgi apparatus (TACC2) nucleolus (TACC2)
cytoskeleton (TACC2) nucleus (TACC2) microtubule organizing center (TACC2)
Anatomy Link Frequency
joints 2
superior 1
saliva 1
TACC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 491 99.92 Very High Very High Very High
Angina 1 98.68 Very High Very High Very High
Arthritis 230 97.80 Very High Very High Very High
methotrexate 14 92.48 High High
cINOD 3 92.32 High High
diclofenac 15 90.76 High High
Osteoarthritis 19 88.08 High High
spinal inflammation 2 84.24 Quite High
Inflammation 25 84.08 Quite High
Rheumatism 6 60.40 Quite High
Disease Link Frequency Relevance Heat
Herpes Zoster 17 100.00 Very High Very High Very High
Acute Coronary Syndrome 10 100.00 Very High Very High Very High
Rheumatoid Arthritis 491 99.92 Very High Very High Very High
Disease 239 99.72 Very High Very High Very High
Cv General 3 Under Development 1 98.68 Very High Very High Very High
Arthritis 219 97.80 Very High Very High Very High
Myocardial Infarction 3 97.68 Very High Very High Very High
Renal Failure 3 97.48 Very High Very High Very High
Dermatomyositis 1 95.64 Very High Very High Very High
Polymyositis 7 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A real-time quantitative PCR assay was used to measure VZV DNA copy number in saliva, and paired sera were assayed for anti-VZV IgG and IgM antibodies.
Gene_expression (assayed) of anti-VZV IgG in saliva associated with herpes zoster
1) Confidence 0.50 Published 2004 Journal J. Med. Virol. Section Abstract Doc Link 15332286 Disease Relevance 2.04 Pain Relevance 0
Detection of anti-CCP1 and anti-CCP2 antibodies by ELISA
Gene_expression (antibodies) of anti-CCP2
2) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.29 Pain Relevance 0.17
Anti-CCP1 and anti-CCP2 antibodies were detected using a commercially available ELISA containing synthetic CCPs (Immunoscan RA, mark 1 and mark 2; Eurodiagnostica, Arnhem, The Netherlands).
Gene_expression (antibodies) of anti-CCP2 associated with rheumatoid arthritis
3) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.29 Pain Relevance 0.15
Indeed, at the 98.5% specificity level only 11 non-RA patients exhibited any ACPA reactivity, of which only three were positive for both AhFibA and anti-CCP2 antibodies (Table 2).
Gene_expression (antibodies) of anti-CCP2 associated with rheumatoid arthritis
4) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.26 Pain Relevance 0.10
The direct antiglobulin test was positive with anti-IgG and anti-C3d in all cases, with anti-IgA in 4/10 cases tested, and negative with anti-IgM.
Neg (negative) Gene_expression (negative) of anti-IgM
5) Confidence 0.08 Published 1996 Journal Br. J. Haematol. Section Abstract Doc Link 8982039 Disease Relevance 0.43 Pain Relevance 0.20
Diagnostic value of anti-MCV and anti-CCP2 testing
Gene_expression (testing) of anti-CCP2
6) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779400 Disease Relevance 0.52 Pain Relevance 0.22
The direct antiglobulin test was positive with anti-IgG and anti-C3d in all cases, with anti-IgA in 4/10 cases tested, and negative with anti-IgM.
Neg (negative) Gene_expression (positive) of anti-IgG
7) Confidence 0.08 Published 1996 Journal Br. J. Haematol. Section Abstract Doc Link 8982039 Disease Relevance 0.43 Pain Relevance 0.20
The direct antiglobulin test was positive with anti-IgG and anti-C3d in all cases, with anti-IgA in 4/10 cases tested, and negative with anti-IgM.
Neg (negative) Gene_expression (positive) of anti-IgA
8) Confidence 0.07 Published 1996 Journal Br. J. Haematol. Section Abstract Doc Link 8982039 Disease Relevance 0.43 Pain Relevance 0.20
Anti-CCP2 level has a good diagnostic and prognostic value [6], but in one study [7] no relation between anti-CCP2 levels and a disease activity score (Disease Activity Score based on 28 joints [DAS28]) was identified.
Gene_expression (levels) of Anti-CCP2 in joints associated with disease
9) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 1.13 Pain Relevance 0.35
No correlation was found between anti-CCP2 levels and DAS28 at baseline (r = 0.12; P = 0.14).
Gene_expression (levels) of anti-CCP2
10) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 0.12 Pain Relevance 0.06
Anti-CCP2 level has a good diagnostic and prognostic value [6], but in one study [7] no relation between anti-CCP2 levels and a disease activity score (Disease Activity Score based on 28 joints [DAS28]) was identified.
Gene_expression (levels) of anti-CCP2 in joints associated with disease
11) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 1.09 Pain Relevance 0.34
Correlations between anti-MCV levels at baseline and SHS at 2 years of follow up and between anti-CCP2 levels and SHS at 2 years of follow up were similar (r = 0.42 and r = 0.41, respectively; P < 0.01).
Gene_expression (levels) of anti-CCP2
12) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 0.18 Pain Relevance 0.06
Together with the high correlation between anti-MCV and anti-CCP2 levels, our data suggest that testing ACPA on citrullinated protein substrates is comparable to testing on artificial citrullinated peptides, and that anti-MCV levels cannot be used to monitor disease activity directly.
Gene_expression (levels) of anti-CCP2 associated with disease
13) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 0.67 Pain Relevance 0.16
Levels of anti-MCV and anti-CCP2 at baseline were highly correlated (r = 0.85; P < 0.01).
Gene_expression (Levels) of anti-CCP2
14) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 0.89 Pain Relevance 0.46
At a diagnostic sensitivity equal to agglutinating RF, the second-generation anti-CCP2 assays detect ACPA of the IgG class with a superior diagnostic specificity for RA.
Gene_expression (detect) of anti-CCP2 in superior associated with rheumatoid arthritis
15) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.01 Pain Relevance 0.44
The commercial enzyme-linked immunosorbent assay (ELISA) was used to detect anti-CCP antibodies, including anti-CCP2 (regular, second generation of CCP antigen) and anti-CCP3 (third generation of CCP antigen) in disease-related specimens and normal controls.
Gene_expression (generation) of anti-CCP2 associated with disease
16) Confidence 0.01 Published 2007 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 17426360 Disease Relevance 2.12 Pain Relevance 0.44
Regarding subclasses of ACS, anti-beta2GPI IgA antibodies were elevated in unstable angina (UA) and myocardial infarction with ST elevation (STEMI), but not in myocardial infarction without ST elevation (NSTEMI).
Gene_expression (subclasses) of anti-beta2GPI associated with acute coronary syndrome, angina and myocardial infarction
17) Confidence 0.00 Published 2004 Journal Lupus Section Abstract Doc Link 15303568 Disease Relevance 1.61 Pain Relevance 0.10

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