INT67253

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Context Info
Confidence 0.33
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 6.48
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pmp22) plasma membrane (Pmp22) cell cycle (Pmp22)
Anatomy Link Frequency
PNS 1
Tooth 1
Pmp22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 3 100.00 Very High Very High Very High
Neuritis 11 97.98 Very High Very High Very High
Inflammation 4 97.76 Very High Very High Very High
Demyelination 7 97.20 Very High Very High Very High
imagery 8 95.50 Very High Very High Very High
Pain 2 73.68 Quite High
Disease Link Frequency Relevance Heat
Disease 7 99.82 Very High Very High Very High
Adhesions 1 99.56 Very High Very High Very High
Charcot Marie Tooth Disease 14 99.42 Very High Very High Very High
Paralysis 8 99.04 Very High Very High Very High
Immunization 1 98.48 Very High Very High Very High
Experimental Autoimmune Neuritis 11 97.98 Very High Very High Very High
INFLAMMATION 3 97.76 Very High Very High Very High
Demyelinating Disease 16 97.20 Very High Very High Very High
Neuropathy 18 96.24 Very High Very High Very High
Syndrome 7 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we compared nerve signal alterations on T2-w and Gf-enhanced T1-w MRI in two different models of acute inflammatory and chronic degenerative demyelination: experimental autoimmune neuritis (EAN) induced by immunization with PNS myelin and experimental Charcot-Marie-Tooth (CMT) disease in rats overexpressing the myelin protein PMP22.
Gene_expression (overexpressing) of myelin protein PMP22 in Tooth associated with disease, neuritis, demyelination, charcot marie tooth disease, inflammation, experimental autoimmune neuritis, immunization and imagery
1) Confidence 0.33 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18061168 Disease Relevance 1.58 Pain Relevance 0.92
Our data suggest a pathogenic role of IgM antibodies against HNK adhesion carbohydrate epitope expressing PNS proteins P0, MAG and PMP-22.
Gene_expression (expressing) of PMP-22 in PNS associated with peripheral nervous system and adhesions
2) Confidence 0.20 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8982118 Disease Relevance 0.88 Pain Relevance 0.72
HNPP is associated with a 1.5-Mb deletion in chromosome 17p11.2-12 and results from reduced expression of the PMP22 gene.
Gene_expression (expression) of PMP22 gene associated with paralysis
3) Confidence 0.15 Published 1999 Journal Brain Pathol. Section Abstract Doc Link 10219749 Disease Relevance 2.05 Pain Relevance 0.07
HNPP is associated with a 1.5-Mb deletion in chromosome 17p11.2-12 and results from reduced expression of the PMP22 gene.
Gene_expression (expression) of PMP22 gene associated with paralysis
4) Confidence 0.14 Published 2001 Journal Phys Med Rehabil Clin N Am Section Abstract Doc Link 11345007 Disease Relevance 1.97 Pain Relevance 0.07

General Comments

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