INT67254

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Context Info
Confidence 0.38
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.70
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural constituent of ribosome (RPLP0) ribosome (RPLP0) intracellular (RPLP0)
ribosome biogenesis (RPLP0) cytoplasm (RPLP0) cytosol (RPLP0)
Anatomy Link Frequency
radial 1
PNS 1
nervous system 1
Schwann cells 1
RPLP0 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 14 100.00 Very High Very High Very High
gABA 11 98.92 Very High Very High Very High
antagonist 6 97.32 Very High Very High Very High
Neuritis 8 94.64 High High
Inflammation 22 83.24 Quite High
diabetic neuropathy 4 77.04 Quite High
Spinal cord 4 73.28 Quite High
ischemia 2 72.56 Quite High
cerebral cortex 5 72.32 Quite High
carpal tunnel syndrome 76 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 2 99.56 Very High Very High Very High
Aging 4 98.80 Very High Very High Very High
Familial Dysautonomia 121 96.80 Very High Very High Very High
Experimental Autoimmune Neuritis 8 94.64 High High
Neurodegenerative Disease 7 88.00 High High
Diabetes Mellitus 4 84.36 Quite High
Apoptosis 4 84.20 Quite High
Pressure And Volume Under Development 6 83.64 Quite High
INFLAMMATION 24 83.24 Quite High
Diabetic Neuropathy 4 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of target genes was normalized to that of RPLP0.
Gene_expression (Expression) of RPLP0
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0 Pain Relevance 0
Since gene expression quantification using RT-qPCR requires a steady reference gene, we selected three genes frequently used for normalization of the data, ABL1, RPLP0, and HPRT1.
Gene_expression (expression) of RPLP0
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.54 Pain Relevance 0
Our data suggest a pathogenic role of IgM antibodies against HNK adhesion carbohydrate epitope expressing PNS proteins P0, MAG and PMP-22.
Gene_expression (expressing) of P0 in PNS associated with peripheral nervous system and adhesions
3) Confidence 0.11 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8982118 Disease Relevance 0.88 Pain Relevance 0.72
PR involvement in the expression of P0 is confirmed by the finding that in cultured rat Schwann cells an antagonist such as mifestone is able to block the stimulatory effect exerted by progesterone and 5?
Gene_expression (expression) of P0 in Schwann cells associated with antagonist
4) Confidence 0.07 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2873263 Disease Relevance 0.37 Pain Relevance 0.25
Indeed aging nervous system, that is associated with a reduction in the synthesis of P0 and PMP22, appears to remain sensitive to some of progesterone's beneficial effects [34,35].
Gene_expression (synthesis) of P0 in nervous system associated with aging
5) Confidence 0.05 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2873263 Disease Relevance 0.68 Pain Relevance 0.21
At E38-P0, virtually all radial glia express BLBP.
Gene_expression (express) of P0 in radial
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

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