INT6726

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 118
Total Number 122
Disease Relevance 65.96
Pain Relevance 24.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 32
blood 5
heart 4
vasculature 2
MCA 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 100 100.00 Very High Very High Very High
Hyperalgesia 24 100.00 Very High Very High Very High
cytokine 13 100.00 Very High Very High Very High
Opioid 13 100.00 Very High Very High Very High
Angina 47 99.90 Very High Very High Very High
Migraine 60 99.84 Very High Very High Very High
narcan 12 99.84 Very High Very High Very High
opioid receptor 10 99.84 Very High Very High Very High
qutenza 437 99.80 Very High Very High Very High
Pain 112 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 265 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 128 100.00 Very High Very High Very High
INFLAMMATION 104 100.00 Very High Very High Very High
Hyperalgesia 68 100.00 Very High Very High Very High
Obesity 65 100.00 Very High Very High Very High
Hypoxia 49 99.98 Very High Very High Very High
Nicotine Addiction 32 99.98 Very High Very High Very High
Diabetes Mellitus 2103 99.96 Very High Very High Very High
Middle Cerebral Artery Infarction 31 99.96 Very High Very High Very High
Angina 21 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naltrexone injection induced a significant elevation of ET-1 plasma concentration in both, dehydrated and control animals. (2) The content of irET-1 in anterior and intermediate lobes of the pituitary in dehydrated rats was markedly higher than in control group. (3) Naltrexone injection caused a rapid and significant reduction irET-1 within the anterior, intermediate and posterior lobes in dehydrated and control animals.
Positive_regulation (elevation) of ET-1 in anterior
1) Confidence 0.70 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178351 Disease Relevance 0.10 Pain Relevance 0.20
These results argue against the hypothesis that increased venomotor tone in DOCA-salt hypertension is caused by increased ET-1 concentration around splanchnic venous smooth muscle cells.
Positive_regulation (increased) of ET-1 in smooth muscle cells associated with hypertension
2) Confidence 0.70 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15471983 Disease Relevance 0.17 Pain Relevance 0
Because the splanchnic blood vessels (especially veins) are important in determining vascular capacitance, we tested the hypothesis that ET-1 levels in the splanchnic vasculature are elevated in hypertensive DOCA-salt compared with normotensive rats.
Positive_regulation (elevated) of ET-1 in vasculature associated with hypertension
3) Confidence 0.70 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15471983 Disease Relevance 0.36 Pain Relevance 0
To test the hypothesis that activation of the endothelin type A (ET(A)) receptor contributes to decreased renal excretory function and increased blood pressure in sensory nerve-degenerated rats fed a high-salt diet, neonatal Wistar rats were given vehicle or capsaicin (CAP, 50 mg/kg s.c.) on the first and second day of life.
Positive_regulation (activation) of endothelin in excretory associated with pressure and volume under development and qutenza
4) Confidence 0.67 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15994858 Disease Relevance 0.25 Pain Relevance 0.12
Unstable angina is associated with an increase in endothelin-1 plasma levels during the acute phase, suggesting a role of this endothelium-derived vasoactive peptide in the pathophysiology of acute coronary artery syndromes.
Positive_regulation (increase) of endothelin-1 in coronary artery associated with angina and vascular disease
5) Confidence 0.67 Published 1993 Journal Cardiology Section Abstract Doc Link 8519005 Disease Relevance 1.27 Pain Relevance 0.71
Plasma levels of endothelin-1 are elevated in acute myocardial infarction with higher levels in complicated infarctions.
Positive_regulation (elevated) of endothelin-1 in Plasma associated with infarction and myocardial infarction
6) Confidence 0.67 Published 1993 Journal Cardiology Section Abstract Doc Link 8519005 Disease Relevance 0.77 Pain Relevance 0.34
Thus, ET(A) receptor antagonists may be of importance in painful states with increased circulating ET-1 levels, as found in cancer and in chronic inflammation.
Positive_regulation (increased) of ET-1 associated with pain, inflammation, cancer and antagonist
7) Confidence 0.67 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16741069 Disease Relevance 0.51 Pain Relevance 0.86
Valuable diagnostic tools are nailfold capillary microscopy and angiography, but probably the best indicator is an increased plasma level of endothelin-1.
Positive_regulation (increased) of endothelin-1 in capillary
8) Confidence 0.66 Published 2004 Journal Rev Med Liege Section Abstract Doc Link 15182034 Disease Relevance 1.51 Pain Relevance 0.30
Furthermore, ET-1 and the ETA receptor are locally upregulated at the site of chronic constriction injury at both the message and the protein levels, suggesting that ET-1 may be involved in establishing pain after the injury.
Positive_regulation (upregulated) of ET-1 associated with pain, eae and injury
9) Confidence 0.65 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16301255 Disease Relevance 0.98 Pain Relevance 0.80
Cells were then washed with DMEM, 10 mM HEPES, 0.5% BSA, 10 mM LiCl, and finally stimulated with buffer or increasing concentrations of ET-1 (10 pM to 100 nM) for 60 min at 37°C.
Positive_regulation (increasing) of ET-1
10) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0
Cells expressing the ETBR did not show any ET-1-induced increase in cAMP.
Positive_regulation (increase) of ET-1-induced
11) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.18
CONCLUSIONS: (1) An elevation of irET-1 in the pituitary gland and peripheral circulation in dehydrated animals may play a role in maintaining of water-electrolyte balance. (2) The mu-opioid system appears to control the ET-1 release from the pituitary in normal and dehydrated animals.
Positive_regulation (elevation) of irET-1 in pituitary gland associated with opioid
12) Confidence 0.61 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178351 Disease Relevance 0.08 Pain Relevance 0.16
Our results indicate that severe hypoxia increased the plasma ir-endothelin-1 level in anesthetized rats.
Positive_regulation (increased) of plasma ir-endothelin-1 in plasma associated with hypoxia
13) Confidence 0.61 Published 1991 Journal Metab. Clin. Exp. Section Abstract Doc Link 1943737 Disease Relevance 0.73 Pain Relevance 0
The observed increase in plasma ir-endothelin-1 level may represent a compensatory mechanism against the blood pressure reduction associated with severe hypoxia.
Positive_regulation (increase) of plasma ir-endothelin-1 in blood associated with hypoxia
14) Confidence 0.61 Published 1991 Journal Metab. Clin. Exp. Section Abstract Doc Link 1943737 Disease Relevance 0.81 Pain Relevance 0
In mildly hypoxic rats, the plasma ir-endothelin-1 concentration was also increased, but this value was not statistically significant.
Positive_regulation (increased) of plasma ir-endothelin-1 in plasma associated with hypoxia
15) Confidence 0.61 Published 1991 Journal Metab. Clin. Exp. Section Abstract Doc Link 1943737 Disease Relevance 0.77 Pain Relevance 0
Furthermore, in anaesthetized rats, diltiazem inhibited ET-1-induced decreases in renal blood flow and increased renal accumulation of IR-ET-1.
Positive_regulation (accumulation) of IR-ET-1 in blood
16) Confidence 0.61 Published 1994 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 8027928 Disease Relevance 0.08 Pain Relevance 0
The results suggest that an increase in vasoconstrictive ET-1 level combined with a decrease in regulatory cytokine, IL-4, and a loss of compensatory action by cNOS may be responsible for gastric mucosal injury caused by indomethacin.
Positive_regulation (increase) of ET-1 associated with injury and cytokine
17) Confidence 0.60 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.53 Pain Relevance 0.16
Since ET-1 exists not only in the vascular endothelial cells but also in the mesangial cells or tubular cells, this increase in ET-1 could be attributed to increased biosynthesis of ET-1 in the renal cells [28-30].
Positive_regulation (increase) of ET-1 in mesangial cells
18) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.07 Pain Relevance 0.04
Since in the present study both ET-1 and NOS activation exhibit a similar course in 28-days diabetic rats, we speculate that NOS stimulation could be due to activation of ETB receptors via elevated ET-1 mechanisms.
Positive_regulation (elevated) of ET-1 associated with diabetes mellitus
19) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.98 Pain Relevance 0
However elevation of ET-1 and NOx in plasma was seen only in 28-days diabetic rats group but not in 14 days-diabetes group.
Positive_regulation (elevation) of ET-1 in plasma associated with diabetes mellitus
20) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.38 Pain Relevance 0

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