INT67275

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.90
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
lamina 1
DRGs 1
L2 (Mus musculus)
Pain Link Frequency Relevance Heat
vanilloid receptor subtype 1 10 100.00 Very High Very High Very High
Calcitonin gene-related peptide 9 99.40 Very High Very High Very High
spinal dorsal horn 2 89.68 High High
Inflammation 4 88.64 High High
burning pain 2 87.28 High High
Facet joint 6 86.08 High High
Pain 8 82.96 Quite High
substance P 8 76.52 Quite High
backache 2 50.00 Quite Low
neuralgia 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 99.96 Very High Very High Very High
Osteogenic Sarcomas 4 99.84 Very High Very High Very High
Paraplegia 3 99.48 Very High Very High Very High
Nociception 1 87.60 High High
INFLAMMATION 4 86.12 High High
Pain 10 82.96 Quite High
Emergencies 1 75.52 Quite High
Cancer 4 66.80 Quite High
Recurrence 1 66.56 Quite High
Metastasis 1 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary osteosarcoma of the L2 lamina presenting as "silent" paraplegia: case report and review of the literature.
Gene_expression (presenting) of L2 in lamina associated with paraplegia and osteogenic sarcomas
1) Confidence 0.66 Published 1995 Journal Eur Spine J Section Title Doc Link 8983662 Disease Relevance 0.98 Pain Relevance 0.08
CONCLUSION: The LBP and radicular pain pathways were likely interrupted by L2 block.
Neg (block) Gene_expression (block) of L2
2) Confidence 0.27 Published 2009 Journal Spine Section Body Doc Link 19730208 Disease Relevance 0 Pain Relevance 0
2.59/mm, n = 14, 79 cells; L2, <130 ?
Gene_expression (<130) of L2
3) Confidence 0.14 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1914403 Disease Relevance 0 Pain Relevance 0
The ratios of IB4-binding and P2X(3) receptor-IR neurons were significantly higher, and that of CGRP-IR neurons was significantly less in L1 and L2 DRGs than those in L3, L4 or L5 DRGs.
Gene_expression (less) of L2 in DRGs associated with ganglion cysts and calcitonin gene-related peptide
4) Confidence 0.03 Published 2005 Journal Eur Spine J Section Abstract Doc Link 15690212 Disease Relevance 0.61 Pain Relevance 0.77
In this study of DRG neurons innervating the L5/6 intervertebral disc, the proportions of BDNF-ir in L1, L2, L3, L4, and L5 DRG neurons were 14%, 12%, 12%, 12%, and 13% and the proportions of VR1-ir L1, L2, L3, L4, and L5 DRG neurons were 10%, 8%, 24%, 19%, and 23%, respectively.
Gene_expression (proportions) of L2 in neurons associated with vanilloid receptor subtype 1
5) Confidence 0.02 Published 2003 Journal J Orthop Sci Section Abstract Doc Link 12560892 Disease Relevance 0.16 Pain Relevance 0.90
In this study of DRG neurons innervating the L5/6 intervertebral disc, the proportions of BDNF-ir in L1, L2, L3, L4, and L5 DRG neurons were 14%, 12%, 12%, 12%, and 13% and the proportions of VR1-ir L1, L2, L3, L4, and L5 DRG neurons were 10%, 8%, 24%, 19%, and 23%, respectively.
Gene_expression (proportions) of L2 in neurons associated with vanilloid receptor subtype 1
6) Confidence 0.02 Published 2003 Journal J Orthop Sci Section Abstract Doc Link 12560892 Disease Relevance 0.15 Pain Relevance 0.88

General Comments

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