INT6728

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Context Info
Confidence 0.65
First Reported 1980
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 43
Total Number 49
Disease Relevance 13.41
Pain Relevance 17.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
hypothalamus 5
lever 5
neurons 3
blood 2
eye 2
Ednra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 361 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
Dynorphin 6 100.00 Very High Very High Very High
tolerance 15 99.96 Very High Very High Very High
Calcium channel 19 99.92 Very High Very High Very High
opioid receptor 17 99.90 Very High Very High Very High
dorsal root ganglion 132 99.84 Very High Very High Very High
ischemia 31 99.82 Very High Very High Very High
Root ganglion neuron 6 99.80 Very High Very High Very High
Morphine 20 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 42 99.96 Very High Very High Very High
Hypertension 38 99.88 Very High Very High Very High
Ganglion Cysts 139 99.84 Very High Very High Very High
Cv Unclassified Under Development 13 99.82 Very High Very High Very High
Congenital Anomalies 50 99.68 Very High Very High Very High
Middle Cerebral Artery Infarction 42 99.16 Very High Very High Very High
Stress 175 99.12 Very High Very High Very High
Pulmonary Hypertension 264 98.86 Very High Very High Very High
Increased Venous Pressure Under Development 150 97.80 Very High Very High Very High
Body Weight 16 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Do ETA receptors participate in the hemodynamic and renal effects of chronic nitric oxide blockade?
Gene_expression (participate) of ETA
1) Confidence 0.65 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 8587446 Disease Relevance 0.53 Pain Relevance 0.06
EtOAc and MeOH extracts of the leaves, which showed slight relaxing activity, led to 4 and rosmarinic acid (5).
Gene_expression (extracts) of EtOAc
2) Confidence 0.65 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 17997242 Disease Relevance 0.24 Pain Relevance 0.15
EtG is usually measured in samples of urine or blood, but can also be detected in oral fluid [28].
Gene_expression (detected) of EtG in blood
3) Confidence 0.59 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2907386 Disease Relevance 0.07 Pain Relevance 0.43
Only a few additional cases of alcohol use, as indicated by the presence of EtG, were detected when analysing oral fluid in addition to using a questionnaire.
Gene_expression (presence) of EtG associated with alcohol
4) Confidence 0.52 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2907386 Disease Relevance 0 Pain Relevance 0.37
Endothelin-1 (ET) produces contraction of cerebral resistance vessels in vitro and in situ, but also is neuroactive causing increases in tissue energy metabolism as measured by [14C]deoxyglucose autoradiography in the intact rat brain.
Gene_expression (produces) of ET in vessels
5) Confidence 0.48 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1331845 Disease Relevance 0 Pain Relevance 0.07
As an index to the action of endothelin- 1 eyedrops to the retina, the expressions of endothelin-A (ETA) and endothelin-B (ETB) receptors in the retina were compared in both eyes.
Gene_expression (expressions) of ETA in eyes
6) Confidence 0.44 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838338 Disease Relevance 0.21 Pain Relevance 0.10
We also examined ETA and ETB mRNA expression by quantitative real-time polymerase chain reaction.
Spec (examined) Gene_expression (expression) of ETA
7) Confidence 0.44 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838338 Disease Relevance 0.19 Pain Relevance 0.09
As a result, the expressions of ETA and ETB receptors are reduced with both immunostaining and the mRNA levels in the left eye, in which endothelin-1 eyedrops were applied at 4 x 10(-5) M.
Gene_expression (expressions) of ETA in eye
8) Confidence 0.44 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838338 Disease Relevance 0.17 Pain Relevance 0.08
The tone of the coronary arteries is critically dependent on an activation of ET receptors and an increased ET-1 associates with a proportional decrease in NO accompanying coronary endothelial dysfunction.46 Vascular abnormalities resulting from over-expression of endothelin receptor, leptin, and NOX and stress contribute to an increased risk of CVD (cardiovascular disease).
Gene_expression (over) of endothelin receptor associated with stress, cardiovascular disease and congenital anomalies
9) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.07 Pain Relevance 0.04
The tone of the coronary arteries is critically dependent on an activation of ET receptors and an increased ET-1 associates with a proportional decrease in NO accompanying coronary endothelial dysfunction.46 Vascular abnormalities resulting from over-expression of endothelin receptor, leptin, and NOX and stress contribute to an increased risk of CVD (cardiovascular disease).
Gene_expression (expression) of endothelin receptor associated with stress, cardiovascular disease and congenital anomalies
10) Confidence 0.34 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.07 Pain Relevance 0.04
Chronic medication of isoproterenol mimicking a stress status related to an increase in sympathetic outflow, causes an impairment of vascular activity which is effectively reversed by endothelin receptor antagonist CPU0213.45 The abnormal vascular activity is characterized by an increase in expression of ETA, NOX, and MMP9 in the vasculature which are attenuated by either CPU0213 a blockade on ET receptors and an antioxidant activity by aminoguanidine.
Gene_expression (expression) of ETA in vasculature associated with stress and antagonist
11) Confidence 0.34 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.80 Pain Relevance 0.05
ETA appears to be at the center in modulating the vascular activity, and an upregulated ETA has been found under multiple conditions: congestive heart failure, hypertension, atherosclerosis, endothelial dysfunction, coronary artery diseases, renal failure, cerebrovascular disease, pulmonary arterial hypertension, and sepsis.3 Interestingly, some substances and prescriptions in Traditional Chinese Medicine (TCM) may be effective in reversing endothelial insults by suppressing the activated ETA, such as quercetin, isorhamnetin, or chelerythrine (protein kinase C (PKC) inhibitor), a modified rehmannia decoction (Liu-wei-di-huang decoction), and total triterpene acids isolated from corni fructus.1,4,5
Gene_expression (suppressing) of ETA in coronary artery associated with pressure and volume under development, heart rate under development, coronary artery disease, renal failure, increased venous pressure under development, sepsis, cerebrovascular disease, kinase c and pulmonary hypertension
12) Confidence 0.33 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.94 Pain Relevance 0.13
Anti-ET IgG had no significant effect on expression, measured by Western blots, of mu, delta or ET-B receptors, but increased kappa opioid (59%) and ET-A (33%) receptor protein expression in the caudate. [35S]-GTP-gamma-S binding assays demonstrated that anti-ET IgG decreased [D-Ala2-MePhe4, Gly-ol5]enkephalin efficacy, but not potency in the caudate.
Gene_expression (expression) of ET associated with enkephalin, opioid and potency
13) Confidence 0.31 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541896 Disease Relevance 0 Pain Relevance 0.99
Anti-ET IgG had no significant effect on expression, measured by Western blots, of mu, delta or ET-B receptors, but increased kappa opioid (59%) and ET-A (33%) receptor protein expression in the caudate. [35S]-GTP-gamma-S binding assays demonstrated that anti-ET IgG decreased [D-Ala2-MePhe4, Gly-ol5]enkephalin efficacy, but not potency in the caudate.
Gene_expression (expression) of ET associated with enkephalin, opioid and potency
14) Confidence 0.31 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541896 Disease Relevance 0 Pain Relevance 1.00
To explore this idea further, we determined the effect of i.c.v. administration of anti-ET-1 IgG (rabbit) on brain opioid receptor and ET receptor expression.
Gene_expression (expression) of ET in brain associated with opioid receptor
15) Confidence 0.31 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541896 Disease Relevance 0 Pain Relevance 0.85
Our group has previously shown that in addition to an ischemia-induced endothelin receptor upregulation, there is an alteration in the vascular angiotensin II receptor response after experimental cerebral ischemia [27].
Gene_expression (upregulation) of endothelin receptor associated with cv general 4 under development and ischemia
16) Confidence 0.30 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.73 Pain Relevance 0.35
Effects of ET-receptor antagonists
Gene_expression (antagonists) of ET-receptor associated with antagonist
17) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.19
Modulation of ET-1/ETA-receptor binding
Gene_expression (/) of ETA-receptor
18) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.40
Modulation of ET-1/ETA-receptor binding
Gene_expression (Modulation) of ETA-receptor
19) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.41
In these vessels, which influence local blood flow and total peripheral resistance and contribute to the development of hypertension[43], ET-receptor subtypes are expressed by several cell types[31], [32], [33].
Gene_expression (expressed) of ET-receptor in blood associated with hypertension
20) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0.27 Pain Relevance 0.46

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