INT673

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Context Info
Confidence 0.68
First Reported 1978
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 28
Disease Relevance 24.24
Pain Relevance 4.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (B2m)
Anatomy Link Frequency
plasma 2
pancreas 2
bone marrow 2
CSF 1
wrist 1
B2m (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 99.62 Very High Very High Very High
headache 6 99.48 Very High Very High Very High
carpal tunnel syndrome 12 98.64 Very High Very High Very High
Multiple sclerosis 12 97.32 Very High Very High Very High
Central nervous system 44 96.72 Very High Very High Very High
shoulder pain 1 93.52 High High
Pain 5 91.88 High High
intrathecal 6 87.84 High High
Paracetamol 8 81.12 Quite High
Inflammation 88 80.72 Quite High
Disease Link Frequency Relevance Heat
Infection 237 99.80 Very High Very High Very High
Pancreatitis 6 99.62 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 30 99.60 Very High Very High Very High
Immunodeficiency 9 99.48 Very High Very High Very High
Headache 6 99.48 Very High Very High Very High
Alzheimer's Dementia 19 99.16 Very High Very High Very High
Chronic Renal Failure 65 98.92 Very High Very High Very High
Hantavirus Infection 8 98.88 Very High Very High Very High
Syndrome 10 98.80 Very High Very High Very High
Renal Failure 19 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several lines of evidence suggest that beta 2-microglobulin (beta 2M) accumulation in long-term hemodialysis (HD) patients results in so-called dialysis-associated amyloidosis (DAA), which is clinically manifested by carpal tunnel syndrome, osteoarthropathy, and the other organ involvements.
Positive_regulation (accumulation) of beta 2M associated with amyloidosis, carpal tunnel syndrome and osteoarthritis
1) Confidence 0.68 Published 1988 Journal Artif Organs Section Abstract Doc Link 3281635 Disease Relevance 0.38 Pain Relevance 0.09
Several lines of evidence suggest that beta 2-microglobulin (beta 2M) accumulation in long-term hemodialysis (HD) patients results in so-called dialysis-associated amyloidosis (DAA), which is clinically manifested by carpal tunnel syndrome, osteoarthropathy, and the other organ involvements.
Positive_regulation (accumulation) of beta 2-microglobulin associated with amyloidosis, carpal tunnel syndrome and osteoarthritis
2) Confidence 0.68 Published 1988 Journal Artif Organs Section Abstract Doc Link 3281635 Disease Relevance 0.38 Pain Relevance 0.09
Serum beta 2m levels were elevated in all patients.
Positive_regulation (elevated) of beta 2m
3) Confidence 0.59 Published 1989 Journal Arthritis Rheum. Section Abstract Doc Link 2660798 Disease Relevance 1.06 Pain Relevance 0.19
MHC class I receptors such as Cd1d1, B2m and Ap3d1 were also upregulated at 96 hr post infection.
Positive_regulation (upregulated) of B2m associated with infection
4) Confidence 0.57 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.94 Pain Relevance 0.13
A considerable increase--about 25 times--of serum beta-2-m was observed, which was more marked in anuric patients and those with a duration of more than 5 years of HD treatment.
Positive_regulation (increase) of beta-2-m
5) Confidence 0.46 Published 1991 Journal Med Interna Section Abstract Doc Link 1670118 Disease Relevance 0.86 Pain Relevance 0.08
Only 3 patients with carcinoma of the pancreas exhibited serum levels within the normal range for both parameters and none of the patients with chronic pancreatitis was shown to have elevated levels of beta2m.
Positive_regulation (elevated) of beta2m in pancreas associated with carcinoma and chronic pancreatitis
6) Confidence 0.44 Published 1978 Journal Klin. Wochenschr. Section Abstract Doc Link 76694 Disease Relevance 0.80 Pain Relevance 0.28
Elevated levels of beta2m and CEA were found in 11 out of 22 patients with carcinoma of the pancreas, which sets off this malignancy from chronic pancreatitis and other malignant tumors.
Positive_regulation (levels) of beta2m in pancreas associated with malignant neoplastic disease, carcinoma and chronic pancreatitis
7) Confidence 0.44 Published 1978 Journal Klin. Wochenschr. Section Abstract Doc Link 76694 Disease Relevance 0.82 Pain Relevance 0.27
For the purpose of preventing the beta 2M accumulation, the efficiency of beta 2M removal during (HPM), hemofiltration (HF), HD, and charcoal hemodiafiltration (HDF) with high-performance membranes (HPM), hemofiltration (HF), HD, and charcoal hemoperfusion was evaluated.
Positive_regulation (accumulation) of beta 2M
8) Confidence 0.43 Published 1988 Journal Artif Organs Section Abstract Doc Link 3281635 Disease Relevance 0.38 Pain Relevance 0.10
Several molecules associated with MHC-I-mediated presentation such as B2m, Fcerg1 and Cd1d1 were also upregulated in our study.
Positive_regulation (upregulated) of B2m
9) Confidence 0.41 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.61 Pain Relevance 0.22
Beta 2 microglobulin (B2m) was also upregulated in acquired immunodeficiency syndrome encephalitis and JC virus infection of the CNS [20,21].
Positive_regulation (upregulated) of B2m associated with syndrome, central nervous system, viral meningitis, infection and immunodeficiency
10) Confidence 0.41 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.58 Pain Relevance 0.24
Four patients had carpal tunnel syndrome with demonstrated amyloid in excised wrist tissues of which 2 were positive for beta 2M.
Positive_regulation (positive) of beta 2M in wrist associated with alzheimer's dementia and carpal tunnel syndrome
11) Confidence 0.38 Published 1988 Journal Am. J. Nephrol. Section Abstract Doc Link 3071144 Disease Relevance 0.38 Pain Relevance 0.10
Beta 2 microglobulin (B2m) was also upregulated in acquired immunodeficiency syndrome encephalitis and JC virus infection of the CNS [20,21].
Positive_regulation (upregulated) of microglobulin associated with syndrome, central nervous system, viral meningitis, infection and immunodeficiency
12) Confidence 0.36 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.64 Pain Relevance 0.24
The presence of hemophagocytosis in the bone marrow and elevation of urinary beta-2-microglobulin (beta-2M) prompted the diagnosis of HPS.
Positive_regulation (elevation) of beta-2-microglobulin in bone marrow associated with hantavirus infection
13) Confidence 0.27 Published 2003 Journal Pediatr Hematol Oncol Section Abstract Doc Link 12775542 Disease Relevance 1.00 Pain Relevance 0.09
The presence of hemophagocytosis in the bone marrow and elevation of urinary beta-2-microglobulin (beta-2M) prompted the diagnosis of HPS.
Positive_regulation (elevation) of beta-2M in bone marrow associated with hantavirus infection
14) Confidence 0.27 Published 2003 Journal Pediatr Hematol Oncol Section Abstract Doc Link 12775542 Disease Relevance 1.00 Pain Relevance 0.09
Using radioimmunological estimation of beta 2-microglobulin (beta 2M), significantly greater serum values were found in 36 dialysis patients (44.4 +/- 20.3 mg/l) in comparison to healthy probands (1.5 +/- 0.2 mg/l).
Positive_regulation (estimation) of beta 2-microglobulin
15) Confidence 0.27 Published 1991 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 1775270 Disease Relevance 0.40 Pain Relevance 0.06
Using radioimmunological estimation of beta 2-microglobulin (beta 2M), significantly greater serum values were found in 36 dialysis patients (44.4 +/- 20.3 mg/l) in comparison to healthy probands (1.5 +/- 0.2 mg/l).
Positive_regulation (estimation) of beta 2M
16) Confidence 0.27 Published 1991 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 1775270 Disease Relevance 0.40 Pain Relevance 0.06
It is concluded that serum beta 2-m is massively elevated in long-term hemodialysis and CAPD patients; contrary to routine hemodialysis with cuprophane membranes, newer more permeable membranes will permit some elimination of beta 2-m.
Positive_regulation (elevated) of beta 2-m associated with renal failure
17) Confidence 0.25 Published 1987 Journal Clin. Nephrol. Section Abstract Doc Link 3297439 Disease Relevance 0.59 Pain Relevance 0.06
However, transient increase in NAG, NAG-B, alpha-GST, beta-Gr, GGT and beta2M enzymes was observed.
Positive_regulation (increase) of beta2M
18) Confidence 0.22 Published 2006 Journal Prz. Lek. Section Abstract Doc Link 17642144 Disease Relevance 0.17 Pain Relevance 0.34
Serum beta 2m concentration was elevated (greater than 2.5 mg/l) in 12 of 16 neurologically symptomatic patients but in only 8 of 21 symptom-free patients (P less than 0.01).
Positive_regulation (elevated) of beta 2m
19) Confidence 0.16 Published 1989 Journal Acta Neurol. Scand. Section Abstract Doc Link 2652977 Disease Relevance 0.85 Pain Relevance 0.07
Our results suggest that elevated beta 2m in CSF and serum is related to the stage of general HIV infection and that elevated CSF beta 2m in the presence of intact BBB may be useful in evaluating CNS involvement in HIV-infected patients.
Positive_regulation (elevated) of beta 2m associated with acquired immune deficiency syndrome or hiv infection and infection
20) Confidence 0.12 Published 1989 Journal Acta Neurol. Scand. Section Abstract Doc Link 2652977 Disease Relevance 1.17 Pain Relevance 0.07

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