INT67308

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NISCH) plasma membrane (NISCH) cytoplasm (NISCH)
NISCH (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 99.52 Very High Very High Very High
narcan 4 98.48 Very High Very High Very High
drug abuse 1 94.36 High High
antidepressant 1 89.00 High High
opiate 1 88.48 High High
addiction 4 87.92 High High
Opioid 3 85.76 High High
mu opioid receptor 2 82.80 Quite High
depression 3 81.36 Quite High
opioid receptor 1 74.32 Quite High
Disease Link Frequency Relevance Heat
Disease 3 99.36 Very High Very High Very High
Drug Dependence 1 94.36 High High
Glioma 2 88.08 High High
Opiate Addiction 4 85.76 High High
Suicidal Behaviour 2 84.72 Quite High
Depression 3 81.36 Quite High
Brain Disease 1 75.00 Quite High
Neurodegenerative Disease 1 67.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor.
Positive_regulation (activation) of IRAS associated with narcan and morphine
1) Confidence 0.62 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16962578 Disease Relevance 0.09 Pain Relevance 0.76
Immunoreactivities of the G beta-subunit increased significantly (p < 0.05) in heroin addicts, compared with controls, and that of G alpha i-1,2 tended to increase in heroin addicts.
Positive_regulation (increase) of i-1
2) Confidence 0.49 Published 1996 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 8986227 Disease Relevance 0.09 Pain Relevance 0.22
The density of I2B-IR is increased in Alzheimer's disease (63%) and decreased in Huntington's disease (56%).
Positive_regulation (increased) of I2B-IR associated with disease
3) Confidence 0.22 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 1.03 Pain Relevance 0.25

General Comments

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