INT67317

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Context Info
Confidence 0.00
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.24
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
HGF 6
endothelial cell 1
hepatocyte 1
stellate cells 1
Hgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 99.92 Very High Very High Very High
Paracetamol 18 99.44 Very High Very High Very High
COX-2 inhibitor 6 97.88 Very High Very High Very High
fibrosis 3 97.36 Very High Very High Very High
anesthesia 4 95.36 Very High Very High Very High
Bile 1 94.48 High High
Inflammation 5 83.04 Quite High
Neuronal nitric oxide synthase 2 73.04 Quite High
melanocortin 1 receptor 1 55.48 Quite High
Chronic pancreatitis 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ulcers 42 99.64 Very High Very High Very High
Hepatocellular Cancer 89 97.68 Very High Very High Very High
Cirrhosis 9 97.60 Very High Very High Very High
Hepatotoxicity 2 96.96 Very High Very High Very High
Skin Cancer 3 88.92 High High
Injury 12 88.28 High High
INFLAMMATION 7 83.04 Quite High
Fibrosis 2 82.84 Quite High
Necrosis 4 82.56 Quite High
Pancreatic Cancer 2 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synergistic stimulation on motility was also observed with those hybrids treated with MSH/IBMX and when rHGF and fibronectin (FN), in combination, were used as chemoattractants.
Gene_expression (used) of rHGF
1) Confidence 0.00 Published 2003 Journal Oncol. Res. Section Abstract Doc Link 14760865 Disease Relevance 0.16 Pain Relevance 0.06
HGF mRNA rapidly expressed at 6 hr after Go treatment, while no HGF mRNA was observed at 6 hr after AAP treatment.
Neg (no) Gene_expression (expressed) of HGF mRNA in HGF associated with paracetamol
2) Confidence 0.78 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8987111 Disease Relevance 0.26 Pain Relevance 0.75
Simultaneous analyses of HGF mRNA expression and liver histology in rats were performed at 6 and 24 hr after treatment with AAP, Go or both.
Gene_expression (expression) of HGF mRNA in HGF associated with paracetamol
3) Confidence 0.78 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8987111 Disease Relevance 0.26 Pain Relevance 0.70
Ulcer healing involves expression of various growth factors including hepatocyte growth factor (HGF) at the ulcer margin and the rise in plasma gastrin but the effects of locally applied HGF and gastrin, which are known to act as trophic factors for the gastric mucosa, with or without neutralizing antibodies against HGF and gastrin or COX-1 and COX-2 inhibitors on ulcer healing and the expression of cyclooxygenase (COX)-1 and COX-2 during this healing have been little studied.
Gene_expression (expression) of HGF in hepatocyte associated with ulcers and cox-2 inhibitor
4) Confidence 0.72 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11192947 Disease Relevance 0.50 Pain Relevance 0.05
CONCLUSIONS: The significant increase of HGF and c-met expression suggests an essential role of this growth factor in the morphological changes during the development of chronic pancreatitis.
Gene_expression (expression) of HGF in HGF
5) Confidence 0.64 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737224 Disease Relevance 0.06 Pain Relevance 0
RESULTS: HGF mRNA expression increased (10-fold) until days 7-14 followed by a decrease to control level.
Gene_expression (expression) of HGF mRNA in HGF
6) Confidence 0.64 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737224 Disease Relevance 0.08 Pain Relevance 0
Each growth factor and specific antibodies against HGF and gastrin (100 ng/100 microl each) were injected just around the ulcer immediately after ulcer induction and this local application was repeated at day 2 following anesthesia and laparotomy.
Gene_expression (injected) of HGF in HGF associated with anesthesia and ulcers
7) Confidence 0.62 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11192947 Disease Relevance 0.93 Pain Relevance 0.18
HGF is a mitogen of mesenchymal origin, and is also reported to stimulate NO production and endothelial cell motility through upregulation of iNOS [18].
Neg (NO) Gene_expression (production) of HGF in endothelial cell
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.16 Pain Relevance 0.21
Our results were in harmony with these data and further showed uniquely that Shh gene overexpression up-regulated iNOS, netrin-1 and HGF in addition to the already reported cytokines.
Gene_expression (overexpression) of HGF in HGF associated with cytokine
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.16 Pain Relevance 0.20
Like HGF, these growth factors are produced and released from non-hepatocyte sources such as activated hepatic stellate cells, myofibroblasts, endothelial cells, Kupffer cells, and bile duct epithelia and do also contribute to hepatocarcinogenesis.
Gene_expression (produced) of HGF in stellate cells associated with bile and cirrhosis
10) Confidence 0.12 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721397 Disease Relevance 0.68 Pain Relevance 0.10

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