INT67318

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.47
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
HGF 12
hepatocyte 1
Hgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 14 100.00 Very High Very High Very High
Paracetamol 18 99.52 Very High Very High Very High
Angina 4 97.76 Very High Very High Very High
Inflammation 17 91.96 High High
Nerve growth factor 4 87.52 High High
qutenza 1 87.24 High High
Thermal hyperalgesia 5 86.44 High High
dorsal root ganglion 11 82.08 Quite High
Pain 34 79.24 Quite High
COX-2 inhibitor 3 66.16 Quite High
Disease Link Frequency Relevance Heat
Thrombosis 12 100.00 Very High Very High Very High
Hypoxia 22 99.34 Very High Very High Very High
Ulcers 21 99.20 Very High Very High Very High
Myocardial Infarction 14 98.80 Very High Very High Very High
Injury 16 97.88 Very High Very High Very High
Cv General 3 Under Development 4 97.76 Very High Very High Very High
Peptic Ulcer 3 97.00 Very High Very High Very High
Sprains And Strains 4 95.12 Very High Very High Very High
Death 6 94.00 High High
Necrosis 2 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that Go rapidly induces HGF mRNA through different mechanisms from AAP-induced liver injury.
Positive_regulation (induces) of HGF mRNA in HGF associated with paracetamol and injury
1) Confidence 0.69 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8987111 Disease Relevance 0.33 Pain Relevance 0.78
Induction of HGF mRNA at 24 hr was observed after treatment with AAP or AAP plus Go.
Positive_regulation (Induction) of HGF mRNA in HGF associated with paracetamol
2) Confidence 0.69 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8987111 Disease Relevance 0.26 Pain Relevance 0.79
Intravenous heparin immediately increased plasma HGF in both Wistar (38.02+/-2.08 ng/mL versus 1.11+/-0.70 ng/mL in untreated rats, P<0.0001) and Ws rats (36.39+/-4.15 ng/mL versus 0.66+/-0.18 ng/mL in NS-treated rats, P<0.0001).
Positive_regulation (increased) of HGF in HGF
3) Confidence 0.66 Published 2002 Journal Circulation Section Body Doc Link 12473563 Disease Relevance 0.15 Pain Relevance 0
BACKGROUND: Plasma concentrations of hepatocyte growth factor (HGF), a powerful angiogenic growth factor inducible by heparin, increase in thrombus-associated disorders such as myocardial infarction and unstable angina.
Positive_regulation (increase) of HGF in hepatocyte associated with angina, myocardial infarction and thrombosis
4) Confidence 0.48 Published 2002 Journal Circulation Section Abstract Doc Link 12473563 Disease Relevance 0.37 Pain Relevance 0.10
We conclude that 1) neutralization of HGF and gastrin by their specificantibodies delays ulcer healing due fall in the microcirculation around the ulcer and a decrease in the COX-2 expression, 2) COX-2 derived prostaglandins may play an important role in acceleration of the ulcer healing by various growth factors including HGF and gastrin, 3) enhancement of the local pool for growth factors such as HGF and gastrin at the ulcer site could offer a new modality for treatment of gastric ulcer.
Positive_regulation (enhancement) of HGF in HGF associated with ulcers and peptic ulcer
5) Confidence 0.46 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11192947 Disease Relevance 0.96 Pain Relevance 0.03
In our study, HGF is also increased in the DRG following CFA treatment.
Positive_regulation (increased) of HGF in HGF
6) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 1.10 Pain Relevance 0.77
CONCLUSIONS: These observations indicate that mast cell degranulation stimulated by thrombin is necessary for the rapid induction of plasma HGF in intravascular thrombus-associated disorders.


Positive_regulation (induction) of HGF in HGF
7) Confidence 0.45 Published 2002 Journal Circulation Section Body Doc Link 12473563 Disease Relevance 0 Pain Relevance 0
Injection of CP48/80 also increased plasma HGF in Wistar rats (9.12+/-1.11 ng/mL versus 0.65+/-0.24 ng/mL in NS group, P=0.004) but not in Ws rats (0.67+/-0.27 ng/mL versus 0.66+/-0.18 ng/mL in NS group, P=0.997).
Neg (not) Positive_regulation (increased) of HGF in HGF
8) Confidence 0.45 Published 2002 Journal Circulation Section Body Doc Link 12473563 Disease Relevance 0.14 Pain Relevance 0
CONCLUSIONS: The significant increase of HGF and c-met expression suggests an essential role of this growth factor in the morphological changes during the development of chronic pancreatitis.
Positive_regulation (increase) of HGF in HGF
9) Confidence 0.41 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737224 Disease Relevance 0.06 Pain Relevance 0
In conclusion ShhMSCs showed upregulation of several angiogenic cytokines and signaling molecules including Ang-1, VEGF, IGF, HGF, iNOS and netrin-1.
Positive_regulation (upregulation) of HGF in HGF associated with cytokine
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0.05
Indeed, hypoxia (1.5% O2) induced a significant increase in accumulation of selected factors like Angiogenin, HGF, IL-8, PDGF-BB, SDF-1 and VEGF-A in the EPC conditioned media compared to normoxia (P<0.05; Table 1).
Positive_regulation (accumulation) of HGF in HGF associated with hypoxia
11) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.42 Pain Relevance 0
Indeed, hypoxia (1.5% O2) induced a significant increase in accumulation of selected factors like Angiogenin, HGF, IL-8, PDGF-BB, SDF-1 and VEGF-A in the EPC conditioned media compared to normoxia (P<0.05; Table 1).
Positive_regulation (increase) of HGF in HGF associated with hypoxia
12) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.42 Pain Relevance 0
A number of growth factors play a specific role in regeneration and it has been proven that a previously described method of physically and chemically stimulating whole blood (to produce autologous conditioned serum) induces concentration increases in FGF-2, HGF, and TGF-beta1.
Positive_regulation (increases) of HGF in HGF
13) Confidence 0.17 Published 2004 Journal Int J Sports Med Section Abstract Doc Link 15532001 Disease Relevance 1.26 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox