INT67333

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.92
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
leukocyte 2
monocyte 2
plasma 1
blood 1
hinge 1
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 21 100.00 Very High Very High Very High
chemokine 2 99.50 Very High Very High Very High
Etanercept 2 98.58 Very High Very High Very High
reflex sympathetic dystrophy 7 98.04 Very High Very High Very High
psoriasis 12 95.28 Very High Very High Very High
tolerance 11 92.56 High High
cINOD 4 91.36 High High
Spinal cord 2 91.16 High High
Arthritis 23 90.72 High High
Pain 4 87.72 High High
Disease Link Frequency Relevance Heat
Pulmonary Disease 32 100.00 Very High Very High Very High
Wound Healing 1 99.56 Very High Very High Very High
Stress 9 99.40 Very High Very High Very High
Frailty 12 98.20 Very High Very High Very High
Disease 45 98.16 Very High Very High Very High
Complex Regional Pain Syndromes 7 98.04 Very High Very High Very High
Carcinoma 3 97.36 Very High Very High Very High
Adhesions 13 96.72 Very High Very High Very High
Decubitus Ulcers 1 95.84 Very High Very High Very High
Psoriasis 12 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indolactam V also promotes homotypic aggregation in U937 cells, which is blocked with either anti-ICAM or anti-LFA-1 antibodies.
Negative_regulation (blocked) of LFA-1
1) Confidence 0.41 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598903 Disease Relevance 0.38 Pain Relevance 0.49
As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis.
Negative_regulation (decreased) of CD18 in plasma associated with stress and reflex sympathetic dystrophy
2) Confidence 0.41 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17702656 Disease Relevance 1.22 Pain Relevance 0.81
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Negative_regulation (down-regulated) of beta2-integrin in monocyte associated with chemokine, carcinoma and adhesions
3) Confidence 0.34 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.49 Pain Relevance 0.14
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Negative_regulation (down-regulated) of Mac-1 in monocyte associated with chemokine, carcinoma and adhesions
4) Confidence 0.34 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.49 Pain Relevance 0.14
Alefacept (IgG1 fusion protein), Etanercept (inhibitor of TNF activity), and Efalizumab (monoclonal antibody that blocks the leukocyte integrin CDIIa/CD18(LFA-1), could provide successful management of the disease in future.
Negative_regulation (blocks) of LFA-1 in leukocyte associated with disease and etanercept
5) Confidence 0.31 Published 2003 Journal Acta Dermatovenerol Croat Section Abstract Doc Link 12718792 Disease Relevance 0.92 Pain Relevance 0.46
We found decreased LFA-1 and VLA-4 on peripheral blood leukocytes in SCI patients and lower levels of CAMs in SCI patients with pressure ulcers than in those without them.
Negative_regulation (decreased) of LFA-1 in blood associated with decubitus ulcers and frailty
6) Confidence 0.20 Published 1996 Journal Immunol. Res. Section Abstract Doc Link 8988397 Disease Relevance 0.90 Pain Relevance 0.08
Alefacept (IgG1 fusion protein), Etanercept (inhibitor of TNF activity), and Efalizumab (monoclonal antibody that blocks the leukocyte integrin CDIIa/CD18(LFA-1), could provide successful management of the disease in future.
Negative_regulation (blocks) of CD18 in leukocyte associated with disease and etanercept
7) Confidence 0.18 Published 2003 Journal Acta Dermatovenerol Croat Section Abstract Doc Link 12718792 Disease Relevance 0.91 Pain Relevance 0.46
Interaction of CD2 with its ligand, CD58 has been blocked by application of a soluble fully human recombinant fusion protein comprising the first extracellular domain of CD58 and the hinge, CH2 and CH3 sequences of human IgG1 (LFA-3-IgG1; alefacept).
Negative_regulation (domain) of LFA-3-IgG1 in hinge
8) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.85 Pain Relevance 0.24
High power images of GFAP and MAC-1 immunoreactivity (Figure 1D-I, Figure 2D-I, Figure 3D-I, and Figure 4D-I) were taken using a 100× oil objective lens.
Negative_regulation (images) of MAC-1 in lens
9) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0 Pain Relevance 0
Inhaled therapy is the cornerstone of treatment comprising anticholinergics which relax airway smooth muscle by blocking cholinergic tone (the primary reversible component in COPD), and beta2-agonists which are nonspecific functional bronchodilators that work via the sympathetic pathway (Cooper and Tashkin 2005).
Negative_regulation (blocking) of beta2-agonists in sympathetic associated with pulmonary disease and agonist
10) Confidence 0.02 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692120 Disease Relevance 0.76 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox