INT67339

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 16
Disease Relevance 1.73
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
Anatomy Link Frequency
uterine 2
extracellular matrix 1
endometrium 1
decidua 1
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 99.50 Very High Very High Very High
Dismenorea 14 98.64 Very High Very High Very High
alcohol 1 91.20 High High
withdrawal 14 68.16 Quite High
cytokine 30 57.64 Quite High
Angina 1 57.60 Quite High
Pain 2 56.84 Quite High
cINOD 2 52.56 Quite High
rheumatoid arthritis 77 50.00 Quite Low
cva 7 14.28 Low Low
Disease Link Frequency Relevance Heat
Premature Birth 13 99.96 Very High Very High Very High
Dysmenorrhea 14 98.64 Very High Very High Very High
Hemorrhage 14 87.24 High High
Pregnancy Complications 7 82.04 Quite High
Pre-term Labor 3 75.00 Quite High
Obesity 14 60.32 Quite High
Body Weight 1 59.64 Quite High
Cardiovascular Disease 2 58.56 Quite High
Cv General 3 Under Development 8 57.60 Quite High
Pain 2 56.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 on expression and release of IGFBP-1 and PRL was mediated by the SMAD signalling pathway, cells were transfected with SMAD 4-specific siRNAs, a siRNA directed against MAPK (a pre-validated control siRNA) or RNA of an unrelated sequence.
Localization (release) of IGFBP-1
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
This may include the involvement of Wnt signalling pathways as previous reports have shown that progesterone-dependent changes in expression of the Wnt antagonist DKK parallel changes in secretion of IGFBP-1 protein [42].
Localization (secretion) of IGFBP-1 associated with antagonist
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0.08
1 within the endometrium plays a critical role in triggering the process of menstruation in cells from non-pregnant endometrium by inhibiting biosynthesis and/or secretion of PRL, IGFBP-1 and tissue factor (TF) via a SMAD-dependent pathway.
Localization (secretion) of IGFBP-1 in endometrium
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.17 Pain Relevance 0.03
1-dependent decrease in concentrations of IGFBP-1 mRNA (Figure 4A) and release of IGFBP-1 protein remained significantly depressed in all cells treated with TGF?
Localization (release) of IGFBP-1
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1-dependent decrease in concentrations of IGFBP-1 mRNA (Figure 4A) and release of IGFBP-1 protein remained significantly depressed in all cells treated with TGF?
Localization (release) of IGFBP-1 mRNA
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 on expression and release of IGFBP1was SMAD independent.
Localization (release) of IGFBP1was
6) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4 and IGFBP-5 localized in the cytoplasm of sSMCs and in the extracellular matrix.
Localization (localized) of IGFBP-1 in extracellular matrix
7) Confidence 0.54 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8988513 Disease Relevance 0.17 Pain Relevance 0.06
OBJECTIVES: The aim of this study was to evaluate the efficacy of the test for the decidual phosphorylated isoform of insulin-like growth factor binding protein-1 (phIGFBP-1) in endocervical secretions in predicting preterm delivery in women with uterine contractions.
Localization (secretions) of insulin-like growth factor binding protein-1 in uterine associated with premature birth and dismenorea
8) Confidence 0.48 Published 2009 Journal Ultrasound Obstet Gynecol Section Abstract Doc Link 19790103 Disease Relevance 0.27 Pain Relevance 0.10
Phosphorylated insulin-like growth factor binding protein-1 in cervical secretions and sonographic cervical length in the prediction of spontaneous preterm delivery.
Localization (secretions) of insulin-like growth factor binding protein-1 associated with premature birth
9) Confidence 0.42 Published 2009 Journal Ultrasound Obstet Gynecol Section Title Doc Link 19790103 Disease Relevance 0.10 Pain Relevance 0.09
BACKGROUND: Phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) is secreted by decidual cells and leaks into cervical secretions when fetal membranes detach from decidua.
Localization (secreted) of Phosphorylated insulin-like growth factor binding protein-1 in decidua
10) Confidence 0.41 Published 2002 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 12174153 Disease Relevance 0.07 Pain Relevance 0.08
Phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) is secreted by decidual cells and may leak into cervical secretions during detachment of the fetal membrane.
Localization (secreted) of Phosphorylated insulin-like growth factor binding protein-1
11) Confidence 0.38 Published 2005 Journal Am J Perinatol Section Abstract Doc Link 16118718 Disease Relevance 0.37 Pain Relevance 0.08
New rapid bed-side test to predict preterm delivery: phosphorylated insulin-like growth factor binding protein-1 in cervical secretions.
Localization (secretions) of phosphorylated insulin-like growth factor binding protein-1 associated with premature birth
12) Confidence 0.36 Published 2002 Journal Acta Obstet Gynecol Scand Section Title Doc Link 12174153 Disease Relevance 0.10 Pain Relevance 0.09
1 also inhibited secretion of PRL and IGFBP-1 proteins by ESCs and surprisingly this response preceded down-regulation of their mRNAs.
Localization (secretion) of IGFBP-1
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
BACKGROUND/AIMS: To determine predictive values of fetal fibronectin and phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) in cervicovaginal secretions and ultrasonographic measurement of cervical length for delivery <35 weeks in patients with uterine contractions.
Localization (secretions) of phosphorylated insulin-like growth factor binding protein-1 in uterine associated with dismenorea
14) Confidence 0.24 Published 2007 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 17339775 Disease Relevance 0.25 Pain Relevance 0.10
IGF-I, IGFBP-1, and IGFBP-3 were measured at Endocrine Sciences (Tarzana, CA, USA).
Localization (measured) of IGFBP-1
15) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.18 Pain Relevance 0.10
Competitive interactions of ochratoxin A (OTA) and several other acidic compounds were utilized to gain insight into the localization of binding sites and the nature of binding interactions between anionic species and human serum albumin (HSA).
Localization (localization) of binding
16) Confidence 0.10 Published 2002 Journal Chem. Biol. Interact. Section Abstract Doc Link 12385724 Disease Relevance 0.05 Pain Relevance 0.05

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