INT67346

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Context Info
Confidence 0.13
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.42
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) cytoplasm (F3)
Anatomy Link Frequency
monocytes 4
plaque 2
F3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 97.60 Very High Very High Very High
Angina 2 80.96 Quite High
Inflammation 4 80.08 Quite High
Inflammatory response 2 69.60 Quite High
analgesia 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rupture 2 98.32 Very High Very High Very High
Sepsis 68 90.04 High High
Shock 6 88.76 High High
Inflammatory Bowel Disease 2 80.64 Quite High
Cv General 3 Under Development 4 75.00 Quite High
Acute Coronary Syndrome 1 75.00 Quite High
Systemic Inflammatory Response Syndrome 2 69.96 Quite High
INFLAMMATION 2 65.32 Quite High
Endotoxemia 2 44.64 Quite Low
Disseminated Intravascular Coagulation 18 11.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Macrophage expression of tissue factor may be responsible for coronary thrombogenicity in patients with plaque rupture.
Regulation (responsible) of Gene_expression (expression) of tissue factor in plaque associated with rupture
1) Confidence 0.13 Published 1996 Journal Circulation Section Abstract Doc Link 8989114 Disease Relevance 0.34 Pain Relevance 0.16
In addition to these effects, Vitamin D may also inhibit the cytokines effect on target cells. vitamin D has an antagonistic effect on TNF-alpha stimulation of monocytes in cultures by down-regulating the surface protein tissue factor (TF) and up-regulating trombomodulin (TM) expression in monocytic cells 18.
Regulation (regulating) of Gene_expression (expression) of tissue factor in monocytes associated with cytokine
2) Confidence 0.09 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 0.54 Pain Relevance 0.22
In addition to these effects, Vitamin D may also inhibit the cytokines effect on target cells. vitamin D has an antagonistic effect on TNF-alpha stimulation of monocytes in cultures by down-regulating the surface protein tissue factor (TF) and up-regulating trombomodulin (TM) expression in monocytic cells 18.
Regulation (regulating) of Gene_expression (expression) of tissue factor in monocytes associated with cytokine
3) Confidence 0.09 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 0.54 Pain Relevance 0.23

General Comments

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