INT67346

Context Info Confidence 0.13 First Reported 1996 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.42 Pain Relevance 0.60

extracellular space (F3) aging (F3) cytoplasm (F3)

Anatomy Link Frequency monocytes 4 plaque 2 F3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 6 97.60 Angina 2 80.96 Inflammation 4 80.08 Inflammatory response 2 69.60 analgesia 2 5.00 Versed 2 5.00 cva 2 5.00

Disease Link Frequency Relevance Heat Rupture 2 98.32 Sepsis 68 90.04 Shock 6 88.76 Inflammatory Bowel Disease 2 80.64 Cv General 3 Under Development 4 75.00 Acute Coronary Syndrome 1 75.00 Systemic Inflammatory Response Syndrome 2 69.96 INFLAMMATION 2 65.32 Endotoxemia 2 44.64 Disseminated Intravascular Coagulation 18 11.84

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

BACKGROUND: Macrophage expression of tissue factor may be responsible for coronary thrombogenicity in patients with plaque rupture.

Regulation (responsible) of Gene_expression (expression) of tissue factor in plaque associated with rupture

1) Confidence 0.13 Published 1996 Journal Circulation Section Abstract Doc Link 8989114 Disease Relevance 0.34 Pain Relevance 0.16

In addition to these effects, Vitamin D may also inhibit the cytokines effect on target cells. vitamin D has an antagonistic effect on TNF-alpha stimulation of monocytes in cultures by down-regulating the surface protein tissue factor (TF) and up-regulating trombomodulin (TM) expression in monocytic cells 18.

Regulation (regulating) of Gene_expression (expression) of tissue factor in monocytes associated with cytokine

2) Confidence 0.09 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 0.54 Pain Relevance 0.22

In addition to these effects, Vitamin D may also inhibit the cytokines effect on target cells. vitamin D has an antagonistic effect on TNF-alpha stimulation of monocytes in cultures by down-regulating the surface protein tissue factor (TF) and up-regulating trombomodulin (TM) expression in monocytic cells 18.

Regulation (regulating) of Gene_expression (expression) of tissue factor in monocytes associated with cytokine

3) Confidence 0.09 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 0.54 Pain Relevance 0.23

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