INT67348

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 2.84
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
liver 1
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 39 99.26 Very High Very High Very High
Morphine 6 98.88 Very High Very High Very High
opiate 2 98.22 Very High Very High Very High
Hippocampus 6 96.00 Very High Very High Very High
Spinal cord 6 90.52 High High
Clonidine 1 61.16 Quite High
Somatostatin 44 58.48 Quite High
Dopamine 18 56.24 Quite High
agonist 16 55.52 Quite High
antagonist 25 40.92 Quite Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 16 99.26 Very High Very High Very High
Meningioma 2 97.92 Very High Very High Very High
Stress 119 97.12 Very High Very High Very High
Breast Cancer 2 94.60 High High
Cancer 44 94.40 High High
Targeted Disruption 47 92.72 High High
Hypertrophy 4 90.84 High High
Hyperinsulinism 30 88.24 High High
Laron Syndrome 3 88.04 High High
Hyperlipidemia 5 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting to note, moreover, that IGF-I transcript levels are significantly downregulated with respect to the GHR-KI2 contrast, but not with respect to the GHR-KI1 contrast (Fig. 1, Table 2).
Negative_regulation (downregulated) of GHR
1) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
Consistent with glucose tolerance-test data, in HG clamp experiments, GhrR KO mice showed a reduction in glucose-stimulated insulin release relative to WT littermates.
Negative_regulation (reduction) of GhrR associated with tolerance and impaired glucose tolerance
2) Confidence 0.36 Published 2011 Journal BMC Physiol Section Abstract Doc Link PMC3024223 Disease Relevance 0.26 Pain Relevance 0.05
In summary, these data provide further compelling evidence that blockade of the GhrR improves insulin sensitivity.
Negative_regulation (blockade) of GhrR
3) Confidence 0.36 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0 Pain Relevance 0
Our results clearly demonstrate that loss of signaling through the GhrR improves insulin sensitivity under conditions of HFD-induced metabolic stress.
Negative_regulation (loss) of GhrR associated with stress
4) Confidence 0.36 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.31 Pain Relevance 0
Therefore, blockade of GhrR signaling does not appear to interfere with gluconeogenesis, but rather may decrease HGP via an alternative mechanism, possibly as a secondary result of decreased hepatic lipid burden (2).
Negative_regulation (blockade) of GhrR
5) Confidence 0.35 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.23 Pain Relevance 0.04
Thus, unlike glucose responsiveness, the underlying improvements of insulin sensitivity resulting from blockade of GhrR signaling do not appear to be affected by diet.
Negative_regulation (blockade) of GhrR
6) Confidence 0.35 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.09 Pain Relevance 0.04
That pegvisomant could block the GH receptor in vitro was also demonstrated in an elegant series of experiments on phosphorylation and transcriptional effects of autocrine hGH in human mammary carcinoma cell lines (Kaulsay et al 2001).


Negative_regulation (block) of GH receptor associated with breast cancer
7) Confidence 0.33 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.42 Pain Relevance 0.09
With multiple linear regression analyses, indices of adiposity were significant determinants of GHBP levels, whereas GH status did not contribute independently to the prediction of GHBP.
Negative_regulation (prediction) of GHBP
8) Confidence 0.33 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.18 Pain Relevance 0.06
Indeed, both studies did not provide any evidence for blocking of the renal GHR.
Negative_regulation (blocking) of GHR
9) Confidence 0.29 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.51 Pain Relevance 0
Catalase and GPX activities, however, were decreased in the liver tissue of the GHR-KO mice.
Negative_regulation (decreased) of GHR-KO in liver
10) Confidence 0.20 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.85 Pain Relevance 0
Northern blot analysis showed that in both tissues the levels of the transcripts for both GHR and GHBP were significantly decreased 4 h after a single dose of morphine.
Negative_regulation (decreased) of GHBP associated with morphine
11) Confidence 0.15 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.59
This result indicates that the opiate does not only affect the receptor protein as shown earlier by binding studies, but also reduces the expression or turnover of the GHR as well as GHBP at the transcription level.
Negative_regulation (reduces) of GHBP associated with opiate
12) Confidence 0.15 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.56

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