INT67349

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Context Info
Confidence 0.66
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.53
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
liver 2
body 1
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 2 81.52 Quite High
Clonidine 1 81.24 Quite High
antagonist 21 76.64 Quite High
Bioavailability 2 46.92 Quite Low
Somatostatin 44 5.00 Very Low Very Low Very Low
Dopamine 18 5.00 Very Low Very Low Very Low
agonist 16 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 11 99.92 Very High Very High Very High
Acromegaly 54 99.26 Very High Very High Very High
Dwarfism 50 97.68 Very High Very High Very High
Body Weight 44 96.68 Very High Very High Very High
Hypoglycemia 12 94.76 High High
Hypothermia 2 94.48 High High
Obesity 33 89.52 High High
Lifespan 28 87.64 High High
Hutchinson-gilford Progeria Syndrome 82 83.80 Quite High
Syndrome 42 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GHBP was inversely proportional to arginine-stimulated GH release (r = -0.346; P = 0.027) and negatively associated with several measures of spontaneous GH release as estimated by deconvolution analysis (GH mass, GH production rate, and mean GH; r = -0.371; P = 0.017, r = -0.393; P = 0.011, and r = -0.343; P = 0.028, respectively)).
Localization (release) of GHBP
1) Confidence 0.66 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.36 Pain Relevance 0.08
However, a relative trend of decreased insulin requirement of GhrR KO mice was maintained throughout the 2nd phase of insulin release [18], and reaching its maximal effect at the point of HG clamp.
Localization (requirement) of GhrR
2) Confidence 0.62 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.19 Pain Relevance 0
Comparable questions may be asked for effects observed in organs other than the liver, ie, are eventual changes in organ responses the result of diminished liver IGF-I synthesis and subsequent decrease in circulating IGF-I or are effects also (or mainly) mediated via local blocking of the GH receptor?
Localization (local) of GH receptor in liver
3) Confidence 0.59 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.18 Pain Relevance 0.07
In patients with acromegaly GH concentrations increase while on GH receptor blockade, similar to that demonstrated in healthy subjects.
Localization (blockade) of GH receptor associated with acromegaly
4) Confidence 0.59 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.24 Pain Relevance 0.08
Indeed, liver GHR mRNA abundance was significantly reduced in both XPCS/XPA and CH/XPA pups.
Localization (abundance) of GHR mRNA in liver
5) Confidence 0.57 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.51 Pain Relevance 0
Growth retardation, hypothermia, hypoglycemia (Figure 4A), and reduced body mass despite normal to increased food intake per gram body weight (Figure 1B) are phenotypes shared by long-lived mice with defects in growth hormone (GH) signaling, including GH-deficient Ames and Snell dwarfs and GH-resistant GH receptor (GHR) knock-out (GHR-KO) mice [31,32].
Localization (receptor) of GHR in body associated with targeted disruption, hypoglycemia, hypothermia and body weight
6) Confidence 0.57 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 1.05 Pain Relevance 0

General Comments

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