INT67350

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.83
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
body 3
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 20 93.48 High High
Clonidine 4 83.04 Quite High
Potency 4 77.52 Quite High
cytokine 10 66.60 Quite High
Somatostatin 44 5.00 Very Low Very Low Very Low
Dopamine 18 5.00 Very Low Very Low Very Low
agonist 16 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 94 98.52 Very High Very High Very High
Obesity 28 95.00 High High
Aging 126 90.40 High High
Acromegaly 54 67.60 Quite High
Body Weight 18 28.64 Quite Low
Htlv Types I And Ii 2 24.32 Low Low
Sprains And Strains 38 17.32 Low Low
Stress 14 8.24 Low Low
Laron Syndrome 2 5.92 Low Low
Cancer 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lean body mass estimated by DEXA scan was negatively associated with GHBP (r = 0.541; P < 0.001).
GHBP Binding (associated) of in body
1) Confidence 0.43 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.37 Pain Relevance 0.08
The GHR-KO mutation was associated with much smaller transcriptional effects than mutations carried by Snell, Ames and Little mice.
GHR Binding (associated) of
2) Confidence 0.35 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.41 Pain Relevance 0
While the GHR-KO mutation was associated with only a small number of transcriptional changes, most of these changes were also found in the other three long-lived models (Fig. 3).
GHR Binding (associated) of
3) Confidence 0.35 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
GHBP was inversely proportional to arginine-stimulated GH release (r = -0.346; P = 0.027) and negatively associated with several measures of spontaneous GH release as estimated by deconvolution analysis (GH mass, GH production rate, and mean GH; r = -0.371; P = 0.017, r = -0.393; P = 0.011, and r = -0.343; P = 0.028, respectively)).
GHBP Binding (associated) of
4) Confidence 0.33 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.36 Pain Relevance 0.08
The circulating high affinity GH-binding protein (GHBP), which derives from the extracellular domain of the hepatic GH receptor, correlates inversely to GH levels and directly to body mass index (BMI) in healthy adults.
GH-binding protein Binding (affinity) of in body associated with obesity
5) Confidence 0.33 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.32 Pain Relevance 0
The circulating high affinity GH-binding protein (GHBP), which derives from the extracellular domain of the hepatic GH receptor, correlates inversely to GH levels and directly to body mass index (BMI) in healthy adults.
GHBP Binding (affinity) of in body associated with obesity
6) Confidence 0.33 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.32 Pain Relevance 0
A former, well-accepted model was that the binding site 1 of the GH molecule binds to the first GH receptor, followed by the binding of site two of the same GH molecule to the second GH receptor, thus leading to dimerization of the receptor (Fuh et al 1992; Behncken and Waters 1999).
GH receptor Binding (binds) of
7) Confidence 0.29 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0 Pain Relevance 0.03
Nevertheless, this molecule has a 4–5-fold reduced binding to GHBP, but a much greater reduction of around 20-fold when binding is studied at the cell surface receptor and presumably explained by steric hindrance (Pradhananga et al 2002).
GHBP Binding (binding) of
8) Confidence 0.29 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.07 Pain Relevance 0.09
The Masu salmon type II ghr bound Gh exclusively [47].
ghr Binding (bound) of
9) Confidence 0.04 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553077 Disease Relevance 0 Pain Relevance 0
Both black sea bream type I and type II ghr have been characterized in ligand binding studies as ghr, not slr, with the use of heterologous (salmon) Prl and Sl [50].
ghr Binding (binding) of
10) Confidence 0.02 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553077 Disease Relevance 0 Pain Relevance 0

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