INT67351

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
liver 2
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 2 81.52 Quite High
Clonidine 1 81.24 Quite High
antagonist 20 76.64 Quite High
Bioavailability 2 47.64 Quite Low
Somatostatin 44 5.00 Very Low Very Low Very Low
Dopamine 18 5.00 Very Low Very Low Very Low
agonist 16 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acromegaly 54 99.62 Very High Very High Very High
Obesity 11 89.52 High High
Body Weight 8 75.44 Quite High
Hypertrophy 4 64.48 Quite High
Meningioma 2 30.64 Quite Low
Cancer 24 27.12 Quite Low
Adenoma 20 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Pituitary Cancer 8 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GHBP was inversely proportional to arginine-stimulated GH release (r = -0.346; P = 0.027) and negatively associated with several measures of spontaneous GH release as estimated by deconvolution analysis (GH mass, GH production rate, and mean GH; r = -0.371; P = 0.017, r = -0.393; P = 0.011, and r = -0.343; P = 0.028, respectively)).
Positive_regulation (arginine-stimulated) of Localization (release) of GHBP
1) Confidence 0.44 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8989245 Disease Relevance 0.36 Pain Relevance 0.08
In patients with acromegaly GH concentrations increase while on GH receptor blockade, similar to that demonstrated in healthy subjects.
Positive_regulation (increase) of Localization (blockade) of GH receptor associated with acromegaly
2) Confidence 0.39 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.24 Pain Relevance 0.08
Comparable questions may be asked for effects observed in organs other than the liver, ie, are eventual changes in organ responses the result of diminished liver IGF-I synthesis and subsequent decrease in circulating IGF-I or are effects also (or mainly) mediated via local blocking of the GH receptor?
Positive_regulation (mediated) of Localization (local) of GH receptor in liver
3) Confidence 0.39 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.18 Pain Relevance 0.07

General Comments

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